Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutathione s transferase mu | 0.036 | 0.035 | 1 |
Schistosoma mansoni | Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) | 0.036 | 0.035 | 0.5 |
Schistosoma mansoni | GST class-mu | 0.036 | 0.035 | 0.5 |
Echinococcus granulosus | glutathione S transferase | 0.036 | 0.035 | 1 |
Onchocerca volvulus | 0.0278 | 0 | 0.5 | |
Plasmodium vivax | glutathione S-transferase, putative | 0.036 | 0.035 | 0.5 |
Echinococcus multilocularis | glutathione S-transferase | 0.036 | 0.035 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.036 | 0.035 | 1 |
Plasmodium falciparum | glutathione S-transferase | 0.036 | 0.035 | 0.5 |
Echinococcus multilocularis | glutathione S transferase | 0.036 | 0.035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2633 | 1 | 1 |
Echinococcus granulosus | glutathione S transferase Mu 1 | 0.036 | 0.035 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.036 | 0.035 | 1 |
Echinococcus multilocularis | prostaglandin H2 D isomerase | 0.036 | 0.035 | 1 |
Echinococcus multilocularis | glutathione s transferase mu | 0.036 | 0.035 | 1 |
Trichomonas vaginalis | glutaminyl-tRNA synthetase, putative | 0.0278 | 0 | 0.5 |
Echinococcus granulosus | prostaglandin H2 D isomerase | 0.036 | 0.035 | 1 |
Schistosoma mansoni | glutathione-S-transferase | 0.036 | 0.035 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.