Detailed information for compound 908968

Basic information

Technical information
  • TDR Targets ID: 908968
  • Name: 3-Bromo-N-(1,3-thiazol-2-yl)benzamide
  • MW: 283.144 | Formula: C10H7BrN2OS
  • H donors: 1 H acceptors: 2 LogP: 2.81 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)C(=O)Nc1nccs1
  • InChi: 1S/C10H7BrN2OS/c11-8-3-1-2-7(6-8)9(14)13-10-12-4-5-15-10/h1-6H,(H,12,13,14)
  • InChiKey: YACCKOLABKUXRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-bromo-N-thiazol-2-yl-benzamide
  • 3-Bromo-N-(2-thiazolyl)benzamide
  • AH-034/04906051
  • EU-0001063
  • ZINC00188418
  • T5390075
  • Oprea1_060540

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.021 0.1818 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0588 0.5807 1
Schistosoma mansoni Smad4 0.0067 0.0316 0.0151
Plasmodium vivax ataxin-2 like protein, putative 0.021 0.1818 1
Echinococcus multilocularis Smad4 0.0067 0.0316 0.0409
Trypanosoma cruzi PAB1-binding protein , putative 0.021 0.1818 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0114 0.0811 0.3927
Brugia malayi RNA binding protein 0.0062 0.0259 0.0259
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0588 0.5807 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0067 0.0316 0.0409
Brugia malayi MH1 domain containing protein 0.0067 0.0316 0.0316
Schistosoma mansoni smad 0.0067 0.0316 0.0151
Brugia malayi hypothetical protein 0.021 0.1818 0.1818
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0114 0.0811 0.3927
Echinococcus multilocularis smad 0.0067 0.0316 0.0409
Schistosoma mansoni hypothetical protein 0.0195 0.1665 0.3707
Brugia malayi MH2 domain containing protein 0.0067 0.0316 0.0316
Onchocerca volvulus 0.0588 0.5807 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0195 0.1665 0.1665
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0588 0.5807 0.5807
Brugia malayi Latrophilin receptor protein 2 0.0195 0.1665 0.1665
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0407 0.3896 1
Brugia malayi Smad1 0.0067 0.0316 0.0316
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0094 0.0599 0.2422
Loa Loa (eye worm) hypothetical protein 0.0421 0.4051 0.4051
Brugia malayi latrophilin 2 splice variant baaae 0.0421 0.4051 0.4051
Trypanosoma brucei PAB1-binding protein , putative 0.021 0.1818 1
Echinococcus granulosus smad 0.0067 0.0316 0.0409
Echinococcus multilocularis GPCR, family 2 0.0195 0.1665 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0094 0.0599 0.2422
Loa Loa (eye worm) MH2 domain-containing protein 0.0067 0.0316 0.0316
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0181 0.1519 0.7034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0195 0.1665 1
Loa Loa (eye worm) transcription factor SMAD2 0.0986 1 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.1665 0.1665
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.0811 0.3927
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0617 0.6107 0.6107
Loa Loa (eye worm) Smad1 0.0067 0.0316 0.0316
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) latrophilin receptor protein 2 0.0195 0.1665 0.1665
Loa Loa (eye worm) isocitrate dehydrogenase 0.0114 0.0811 0.0811
Echinococcus multilocularis isocitrate dehydrogenase 0.0114 0.0811 0.3927
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.0811 0.3927
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0588 0.5807 1
Schistosoma mansoni hypothetical protein 0.0094 0.0599 0.0898
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1519 0.7034
Loa Loa (eye worm) RNA binding protein 0.0062 0.0259 0.0259
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0588 0.5807 1
Brugia malayi N-terminal motif family protein 0.039 0.3715 0.3715
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0588 0.5807 0.5
Leishmania major hypothetical protein, conserved 0.0181 0.1519 0.7034
Schistosoma mansoni hypothetical protein 0.0195 0.1665 0.3707
Brugia malayi MH1 domain containing protein 0.0067 0.0316 0.0316
Brugia malayi hypothetical protein 0.0135 0.1035 0.1035
Loa Loa (eye worm) MH1 domain-containing protein 0.0067 0.0316 0.0316
Toxoplasma gondii LsmAD domain-containing protein 0.021 0.1818 1
Schistosoma mansoni hypothetical protein 0.0195 0.1665 0.3707
Schistosoma mansoni smad1 5 8 and 0.0067 0.0316 0.0151
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0195 0.1665 1
Schistosoma mansoni hypothetical protein 0.0421 0.4051 1
Brugia malayi TAR-binding protein 0.0062 0.0259 0.0259
Echinococcus multilocularis mothers against decapentaplegic 5 0.0067 0.0316 0.0409
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0259 0.0259
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0588 0.5807 0.5
Schistosoma mansoni smad1 5 8 and 0.0067 0.0316 0.0151
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0588 0.5807 0.5807
Plasmodium falciparum ataxin-2 like protein, putative 0.021 0.1818 1
Echinococcus granulosus GPCR family 2 0.0195 0.1665 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.0811 0.3927
Brugia malayi MH2 domain containing protein 0.0067 0.0316 0.0316
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0195 0.1665 1
Schistosoma mansoni hypothetical protein 0.0195 0.1665 0.3707
Loa Loa (eye worm) hypothetical protein 0.0617 0.6107 0.6107
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0259 0.0259
Echinococcus granulosus Smad4 0.0067 0.0316 0.0409
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0195 0.1665 1
Loa Loa (eye worm) hypothetical protein 0.021 0.1818 0.1818
Schistosoma mansoni smad1 5 8 and 0.0067 0.0316 0.0151
Loa Loa (eye worm) hypothetical protein 0.039 0.3715 0.3715
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0617 0.6107 0.6107
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0067 0.0316 0.0151
Trypanosoma cruzi PAB1-binding protein , putative 0.021 0.1818 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0067 0.0316 0.0409
Brugia malayi isocitrate dehydrogenase 0.0114 0.0811 0.0811
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0067 0.0316 0.0409
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0114 0.0811 0.1456
Brugia malayi Calcitonin receptor-like protein seb-1 0.0617 0.6107 0.6107
Loa Loa (eye worm) MH2 domain-containing protein 0.0986 1 1
Brugia malayi Isocitrate dehydrogenase 0.0114 0.0811 0.0811
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0588 0.5807 1
Leishmania major hypothetical protein, conserved 0.021 0.1818 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0588 0.5807 0.5
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0588 0.5807 0.5
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0588 0.5807 1
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1519 0.7034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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