Detailed information for compound 910826

Basic information

Technical information
  • TDR Targets ID: 910826
  • Name: AJ-292/12415047
  • MW: 336.472 | Formula: C16H20N2O2S2
  • H donors: 0 H acceptors: 1 LogP: 3.44 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nc2sc3c(c2c(=O)n1CC(=C)C)CC(OC3)(C)C
  • InChi: 1S/C16H20N2O2S2/c1-9(2)7-18-14(19)12-10-6-16(3,4)20-8-11(10)22-13(12)17-15(18)21-5/h1,6-8H2,2-5H3
  • InChiKey: XXYYEIHFCDHTJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_720512
  • ZINC00371850
  • Oprea1_818939
  • STOCK1S-28279

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ubiquitin modifier activating enzyme 6 0.0136 0.7636 0.7567
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0163 0.968 0.9671
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0163 0.968 0.9671
Brugia malayi MH2 domain containing protein 0.0119 0.6411 0.6623
Schistosoma mansoni biogenic amine (5HT) receptor 0.0163 0.968 0.9671
Schistosoma mansoni biogenic amine (5HT) receptor 0.0163 0.968 0.9671
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.1084 0.0825
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0163 0.968 0.9671
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) neuropeptide F receptor 0.0163 0.968 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0163 0.968 1
Schistosoma mansoni hypothetical protein 0.0047 0.1084 0.0825
Schistosoma mansoni hypothetical protein 0.0168 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Schistosoma mansoni alpha-1 adrenergic receptor 0.0163 0.968 0.9671
Onchocerca volvulus 0.0163 0.968 0.5
Schistosoma mansoni biogenic amine receptor 0.0163 0.968 0.9671
Echinococcus granulosus G protein coupled receptor 139 0.0163 0.968 0.9671
Onchocerca volvulus 0.0163 0.968 0.5
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Schistosoma mansoni amine GPCR 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Schistosoma mansoni app binding protein 0.0045 0.0974 0.0712
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0163 0.968 1
Plasmodium falciparum ubiquitin-activating enzyme E1 0.0136 0.7636 1
Brugia malayi GnHR receptor homolog 0.0163 0.968 1
Brugia malayi RE15519p 0.0163 0.968 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0163 0.968 0.9671
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.1084 0.0825
Brugia malayi ThiF family protein 0.0045 0.0974 0.1007
Leishmania major ubiquitin-activating enzyme e1, putative 0.0072 0.2948 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0163 0.968 1
Loa Loa (eye worm) neuropeptide F receptor 0.0163 0.968 1
Echinococcus granulosus tm gpcr rhodopsin 0.0163 0.968 0.9671
Trichomonas vaginalis ubiquitin-activating enzyme E1c, putative 0.0105 0.5365 1
Echinococcus granulosus neuropeptide s receptor 0.0163 0.968 0.9671
Echinococcus multilocularis g-protein coupled receptor 0.0163 0.968 0.9671
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1049 0.0789
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.968 0.9671
Plasmodium vivax ubiquitin activating enzyme, putative 0.0054 0.1619 1
Schistosoma mansoni hypothetical protein 0.0163 0.968 0.9671
Echinococcus multilocularis ubiquitin modifier activating enzyme 1 0.0136 0.7636 0.7567
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0163 0.968 0.9671
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.1296 0.0375
Brugia malayi hypothetical protein 0.005 0.1296 0.1339
Brugia malayi Tachykinin-like peptides receptor 99D 0.0163 0.968 1
Echinococcus granulosus orexin receptor type 2 0.0163 0.968 0.9671
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.1296 0.4338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Brugia malayi neuropeptide F receptor 0.0163 0.968 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0163 0.968 1
Echinococcus multilocularis neuropeptides capa receptor 0.0163 0.968 0.9671
Trypanosoma brucei trypanothione reductase 0.0046 0.1049 0.0378
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.968 0.9671
Schistosoma mansoni clathrin coat associated protein ap-50 0.0084 0.3805 0.3625
Echinococcus granulosus biogenic amine 5HT receptor 0.0163 0.968 0.9671
Brugia malayi hypothetical protein 0.0036 0.0282 0.0292
Onchocerca volvulus 0.0163 0.968 0.5
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1084 0.0126
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Schistosoma mansoni amine GPCR 0.0163 0.968 0.9671
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.4231 0.3741
Schistosoma mansoni hypothetical protein 0.0101 0.5082 0.4939
Onchocerca volvulus 0.0163 0.968 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0163 0.968 0.9671
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.1084 0.0126
Schistosoma mansoni neuropeptide receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) TYRA-2 protein 0.0163 0.968 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0163 0.968 0.9671
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus granulosus tm gpcr rhodopsin 0.0163 0.968 0.9671
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.1084 0.0825
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.0072 0.2984 0.278
Brugia malayi G protein-coupled receptor F59B2.13 0.0163 0.968 1
Echinococcus granulosus sex peptide receptor 0.0163 0.968 0.9671
Echinococcus multilocularis g protein coupled receptor 0.0163 0.968 0.9671
Echinococcus granulosus allatostatin A receptor 0.0163 0.968 0.9671
Schistosoma mansoni hypothetical protein 0.0163 0.968 0.9671
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.5418 0.8342
Schistosoma mansoni hypothetical protein 0.0163 0.968 0.9671
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0054 0.1619 0.1375
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis fmrfamide receptor 0.0163 0.968 0.9671
Onchocerca volvulus 0.0163 0.968 0.5
Entamoeba histolytica ThiF family protein 0.0045 0.0974 0.0941
Brugia malayi Dopamine receptor 0.0163 0.968 1
Trypanosoma cruzi NEDD8-activating enzyme E1 regulatory subunit, putative 0.0045 0.0974 0.1447
Echinococcus multilocularis fmrfamide receptor 0.0163 0.968 0.9671
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0163 0.968 0.9671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.4231 0.4063
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.968 0.9671
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0072 0.2984 0.278
Schistosoma mansoni neuropeptide F-like receptor 0.0163 0.968 0.9671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis geminin 0.0168 1 1
Onchocerca volvulus 0.0163 0.968 0.5
Onchocerca volvulus 0.0163 0.968 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0163 0.968 0.9671
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.5082 0.525
Loa Loa (eye worm) hypothetical protein 0.0148 0.8526 0.8675
Echinococcus multilocularis GPCR, family 2 0.0047 0.1084 0.0825
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0109 0.5676 0.555
Schistosoma mansoni clathrin coat associated protein ap-50 0.0084 0.3805 0.3625
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0163 0.968 0.9671
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.0072 0.2984 0.278
Leishmania major ubiquitin-activating enzyme e1, putative 0.0051 0.1389 0.2098
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0163 0.968 0.9671
Echinococcus granulosus alpha 1A adrenergic receptor 0.0163 0.968 0.9671
Echinococcus granulosus neuropeptide FF receptor 2 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0163 0.968 0.9671
Echinococcus multilocularis sex peptide receptor 0.0163 0.968 0.9671
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0163 0.968 0.9671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.968 0.9671
Mycobacterium tuberculosis Probable reductase 0.0105 0.5418 0.8342
Onchocerca volvulus 0.0163 0.968 0.5
Schistosoma mansoni biogenic amine receptor 0.0163 0.968 0.9671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0054 0.1619 0.1375
Onchocerca volvulus Neuropeptide F receptor homolog 0.0163 0.968 0.5
Brugia malayi AKH receptor 0.0163 0.968 1
Echinococcus granulosus dro:myosuppressin receptor 0.0163 0.968 0.9671
Schistosoma mansoni opsin-like receptor 0.0163 0.968 0.9671
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.8526 0.8808
Brugia malayi hypothetical protein 0.0163 0.968 1
Brugia malayi Dopamine receptor protein 2 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.6286 1
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0054 0.1619 0.1375
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.5418 0.8342
Loa Loa (eye worm) ube1-prov protein 0.0136 0.7636 0.7652
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Brugia malayi hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis G protein coupled receptor 139 0.0163 0.968 0.9671
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0105 0.5365 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.0072 0.2948 1
Brugia malayi hypothetical protein 0.0163 0.968 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Echinococcus granulosus tachykinin peptides receptor 99D 0.0163 0.968 0.9671
Echinococcus granulosus neuropeptides capa receptor 0.0163 0.968 0.9671
Brugia malayi Melatonin receptor type 1A 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Brugia malayi glutathione reductase 0.0046 0.1049 0.1084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.968 0.9671
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.1296 0.0375
Schistosoma mansoni hypothetical protein 0.0047 0.1084 0.0825
Schistosoma mansoni opsin-like receptor 0.0163 0.968 0.9671
Onchocerca volvulus 0.0163 0.968 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0163 0.968 0.9671
Schistosoma mansoni neuropeptide receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Brugia malayi hypothetical protein 0.0163 0.968 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0163 0.968 0.9671
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.4231 0.4371
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0136 0.7636 1
Onchocerca volvulus 0.0163 0.968 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0163 0.968 0.9671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.4231 0.4063
Echinococcus granulosus biogenic amine 5HT receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.6411 0.6245
Brugia malayi Serotonin receptor 0.0163 0.968 1
Onchocerca volvulus 0.0163 0.968 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) G-protein coupled receptor 0.0163 0.968 1
Brugia malayi Thioredoxin reductase 0.0046 0.1049 0.1084
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.968 0.9671
Loa Loa (eye worm) G-protein coupled receptor 0.0163 0.968 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.1084 0.112
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0072 0.2948 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0163 0.968 0.9671
Echinococcus multilocularis somatostatin receptor 0.0163 0.968 0.9671
Echinococcus multilocularis g protein coupled receptor 0.0163 0.968 0.9671
Echinococcus multilocularis neuropeptide FF receptor 2 0.0163 0.968 0.9671
Brugia malayi sulfakinin receptor protein 0.0163 0.968 1
Brugia malayi ORL1-like opioid receptor 0.0163 0.968 1
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.0072 0.2948 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.968 0.9671
Onchocerca volvulus 0.0163 0.968 0.5
Schistosoma mansoni biogenic amine receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Brugia malayi follicle stimulating hormone receptor 0.0163 0.968 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.8526 0.8675
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0163 0.968 0.9671
Leishmania major hypothetical protein, conserved 0.005 0.1296 0.163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.4231 0.4063
Brugia malayi G-protein coupled receptor 0.0163 0.968 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus granulosus tm gpcr rhodopsin 0.0163 0.968 0.9671
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0163 0.968 0.9671
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0163 0.968 0.9671
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Brugia malayi hypothetical protein 0.0163 0.968 1
Echinococcus granulosus g protein coupled receptor 0.0163 0.968 0.9671
Schistosoma mansoni neuropeptide f receptor 76f 0.0163 0.968 0.9671
Schistosoma mansoni adenoreceptor 0.0163 0.968 0.9671
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.1296 0.2841
Echinococcus multilocularis neuropeptide receptor 0.0163 0.968 0.9671
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1049 0.0789
Schistosoma mansoni amine GPCR 0.0163 0.968 0.9671
Brugia malayi hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0163 0.968 0.9671
Schistosoma mansoni histamine h1 receptor 0.0163 0.968 0.9671
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.1084 0.0825
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.6286 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0163 0.968 0.9671
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0163 0.968 1
Echinococcus granulosus ubiquitin modifier activating enzyme 1 0.0136 0.7636 0.7567
Schistosoma mansoni neuropeptide receptor 0.0163 0.968 0.9671
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0163 0.968 0.9671
Brugia malayi hypothetical protein 0.0163 0.968 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.4231 0.4063
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.1296 0.2841
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.1084 0.112
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.0072 0.2984 0.2309
Brugia malayi ube1-prov protein 0.0136 0.7636 0.7889
Loa Loa (eye worm) melatonin receptor type 1A 0.0163 0.968 1
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0044 0.0888 0.0623
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.968 0.9671
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0054 0.1657 0.1901
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0163 0.968 0.9671
Brugia malayi larval opioid receptor 0.0163 0.968 1
Schistosoma mansoni hypothetical protein 0.0047 0.1084 0.0825
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Brugia malayi putative neuropeptide receptor 0.0163 0.968 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.4231 0.4063
Onchocerca volvulus 0.0163 0.968 0.5
Brugia malayi G-protein coupled receptor 0.0163 0.968 1
Brugia malayi Serotonin receptor 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Onchocerca volvulus 0.0163 0.968 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0163 0.968 0.9671
Brugia malayi hypothetical protein 0.0163 0.968 1
Echinococcus granulosus neuropeptide Y receptor 0.0163 0.968 0.9671
Echinococcus granulosus neuropeptides capa receptor 0.0163 0.968 0.9671
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0163 0.968 1
Echinococcus multilocularis allatostatin A receptor 0.0163 0.968 0.9671
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0054 0.1619 0.0865
Echinococcus multilocularis neuropeptide receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.968 0.9671
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0163 0.968 0.9671
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.0072 0.2984 0.3083
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0045 0.0974 0.0411
Echinococcus multilocularis neuropeptides capa receptor 0.0163 0.968 0.9671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Toxoplasma gondii hypothetical protein 0.0054 0.1619 0.3205
Echinococcus multilocularis NEDD8 activating enzyme E1 regulatory subunit 0.0045 0.0974 0.0712
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.968 0.9671
Echinococcus multilocularis G-protein coupled receptor, putative 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.4231 0.4063
Echinococcus multilocularis serotonin receptor 0.0163 0.968 0.9671
Schistosoma mansoni myosin xvIII 0.0163 0.968 0.9671
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.968 0.9671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.4231 0.4063
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.968 0.9671
Echinococcus granulosus neuropeptide Y receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus granulosus somatostatin receptor 0.0163 0.968 0.9671
Giardia lamblia Ubiquitin-conjugating enzyme E1 0.0072 0.2948 0.5
Schistosoma mansoni hypothetical protein 0.0163 0.968 0.9671
Schistosoma mansoni opsin-like receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1049 0.0086
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis g protein coupled receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0163 0.968 1
Echinococcus multilocularis serotonin receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.005 0.1296 0.037
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0105 0.5365 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus multilocularis neuropeptide s receptor 0.0163 0.968 0.9671
Trichomonas vaginalis ubiquitin-activating enzyme E1 X, putative 0.0047 0.1078 0.0636
Toxoplasma gondii thioredoxin reductase 0.0046 0.1049 0.0371
Schistosoma mansoni neuropeptide receptor 0.0163 0.968 0.9671
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.6286 1
Brugia malayi hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Echinococcus granulosus serotonin receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0163 0.968 0.9671
Echinococcus multilocularis orexin receptor type 2 0.0163 0.968 0.9671
Echinococcus granulosus neuropeptide receptor A26 0.0163 0.968 0.9671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.968 0.9671
Schistosoma mansoni hypothetical protein 0.0047 0.1084 0.0825
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Schistosoma mansoni amine GPCR 0.0163 0.968 0.9671
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0163 0.968 0.9671
Brugia malayi G protein-coupled receptor 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Onchocerca volvulus 0.0163 0.968 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0051 0.1389 0.2098
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0163 0.968 1
Echinococcus granulosus hypothetical protein 0.0163 0.968 0.9671
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.5418 0.8342
Echinococcus granulosus g protein coupled receptor 0.0163 0.968 0.9671
Brugia malayi neuropeptide F receptor 0.0163 0.968 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0163 0.968 0.9671
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.5418 0.8342
Loa Loa (eye worm) hypothetical protein 0.0054 0.1619 0.074
Echinococcus granulosus NEDD8 activating enzyme E1 regulatory subunit 0.0045 0.0974 0.0712
Echinococcus granulosus neuropeptide receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.6411 0.6245
Echinococcus multilocularis neuropeptide Y receptor 0.0163 0.968 0.9671
Entamoeba histolytica ubiquitin-activating enzyme E1 1, putative 0.0105 0.5365 0.6912
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0101 0.5082 0.4718
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.1296 0.163
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.6286 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0163 0.968 0.9671
Brugia malayi Dopamine receptor protein 1 0.0163 0.968 1
Echinococcus granulosus GPCR family 2 0.0047 0.1084 0.0825
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Brugia malayi ThiF family protein 0.0054 0.1619 0.1672
Schistosoma mansoni hypothetical protein 0.0168 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.8526 0.8808
Echinococcus granulosus g-protein coupled receptor 0.0163 0.968 0.9671
Echinococcus granulosus g protein coupled receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.5418 0.8342
Onchocerca volvulus 0.0163 0.968 0.5
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Schistosoma mansoni amine GPCR 0.0163 0.968 0.9671
Loa Loa (eye worm) glutathione reductase 0.0046 0.1049 0.0086
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0072 0.2984 0.3674
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0163 0.968 0.5
Echinococcus granulosus fmrfamide receptor 0.0163 0.968 0.9671
Echinococcus granulosus neuropeptide receptor 0.0163 0.968 0.9671
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0163 0.968 0.9671
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.1296 0.1601
Echinococcus multilocularis ubiquitin modifier activating enzyme 6 0.0136 0.7636 0.7567
Brugia malayi putative neuropeptide receptor NPR1 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.968 0.9671
Schistosoma mansoni growth hormone secretagogue receptor 0.0163 0.968 0.9671
Onchocerca volvulus 0.0163 0.968 0.5
Leishmania major trypanothione reductase 0.0046 0.1049 0.0378
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0045 0.0974 0.0411
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0163 0.968 0.9671
Echinococcus multilocularis neuropeptide Y receptor 0.0163 0.968 0.9671
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.968 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1049 0.1771
Brugia malayi hypothetical protein 0.0163 0.968 1
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.0072 0.2984 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0163 0.968 0.9671

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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