Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0044 | 0.0766 | 0.1295 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0044 | 0.0766 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0237 | 0.6461 | 0.6661 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0766 | 0.079 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0044 | 0.0766 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0219 | 0.5915 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0044 | 0.0766 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0063 | 0.1313 | 0.1353 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0219 | 0.5915 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0044 | 0.0766 | 0.5 |
Mycobacterium ulcerans | monoamine oxidase | 0.0044 | 0.0766 | 0.5 |
Onchocerca volvulus | CoRest homolog | 0.0357 | 1 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0044 | 0.0766 | 0.5 |
Giardia lamblia | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.97 | 0.97 |
Schistosoma mansoni | amine oxidase | 0.0044 | 0.0766 | 0.1295 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0044 | 0.0766 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0766 | 0.0766 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0044 | 0.0766 | 0.1295 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1313 | 0.1313 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0219 | 0.5915 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0044 | 0.0766 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0044 | 0.0766 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0044 | 0.0766 | 0.5 |
Entamoeba histolytica | SWIRM domain protein | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0044 | 0.0766 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0044 | 0.0766 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0044 | 0.0766 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0044 | 0.0766 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0044 | 0.0766 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0044 | 0.0766 | 0.1295 |
Mycobacterium ulcerans | oxidoreductase | 0.0044 | 0.0766 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0044 | 0.0766 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.6461 | 0.6461 |
Schistosoma mansoni | amine oxidase | 0.0044 | 0.0766 | 0.1295 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0044 | 0.0766 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0044 | 0.0766 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0044 | 0.0766 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.5915 | 0.5915 |
Entamoeba histolytica | SWIRM domain protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | 0.0044 | 0.0766 | 0.1295 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0044 | 0.0766 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.5915 | 0.5915 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0347 | 0.97 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0044 | 0.0766 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0766 | 0.0766 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Smax (functional) | = -15 % | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cell membranes at 10 uM after 60 mins by [35S]GTPgammaS binding assay relative to U69593 | ChEMBL. | 24973818 |
Smax (functional) | = -2 % | Agonist activity at human recombinant mu opioid receptor expressed in CHO cell membranes at 10 uM after 60 mins by [35S]GTPgammaS binding assay relative to DAMGO | ChEMBL. | 24973818 |
Smax (functional) | = 4 % | Agonist activity at human recombinant NOPR receptor expressed in CHO cell membranes at 10 uM after 60 mins by [35S]GTPgammaS binding assay relative to nociceptin | ChEMBL. | 24973818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.