Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0147 | 0.0571 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0571 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1003 | 0.4744 | 0.4426 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0067 | 0.0182 | 0.264 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0067 | 0.0182 | 0.2746 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0067 | 0.0182 | 0.2746 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0571 | 0.8171 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0571 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0067 | 0.0182 | 0.2244 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0067 | 0.0182 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0147 | 0.0571 | 0.8171 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0067 | 0.0182 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0012 | 0.0207 |
Echinococcus multilocularis | 0.0147 | 0.0571 | 1 | |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1003 | 0.4744 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0147 | 0.0571 | 0.8171 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1003 | 0.4744 | 0.4426 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0147 | 0.0571 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0147 | 0.0571 | 0.1138 |
Leishmania major | UDP-galactopyranose mutase | 0.0147 | 0.0571 | 0.8171 |
Entamoeba histolytica | fatty acid elongase, putative | 0.013 | 0.0491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0571 | 1 |
Schistosoma mansoni | amine oxidase | 0.0147 | 0.0571 | 0.8171 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0171 | 0.0691 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2082 | 1 | 1 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0171 | 0.0691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0571 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0147 | 0.0571 | 0.8171 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0067 | 0.0182 | 0.2746 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0171 | 0.0691 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0147 | 0.0571 | 0.8265 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0067 | 0.0182 | 0.3226 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0571 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0171 | 0.0691 | 0.1392 |
Plasmodium vivax | hypothetical protein, conserved | 0.0147 | 0.0571 | 0.1138 |
Leishmania major | dihydroorotate dehydrogenase | 0.0171 | 0.0691 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0171 | 0.0691 | 0.0127 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1003 | 0.4744 | 1 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0037 | 0.0035 | 0.1934 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0147 | 0.0571 | 0.8171 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0147 | 0.0571 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0171 | 0.0691 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0147 | 0.0571 | 0.1138 |
Schistosoma mansoni | amine oxidase | 0.0147 | 0.0571 | 0.8171 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1003 | 0.4744 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0147 | 0.0571 | 0.1138 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0067 | 0.0182 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0171 | 0.0691 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1936 | 0.9286 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.013 | 0.0491 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0171 | 0.0691 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0171 | 0.0691 | 0.1392 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0147 | 0.0571 | 0.1138 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0171 | 0.0691 | 0.0138 |
Trypanosoma cruzi | leucyl-tRNA synthetase, putative | 0.0037 | 0.0035 | 0.0511 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0067 | 0.0182 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1003 | 0.4744 | 0.4788 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1003 | 0.4744 | 0.4426 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0067 | 0.0182 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0067 | 0.0182 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.013 | 0.0491 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0147 | 0.0571 | 0.8171 |
Entamoeba histolytica | fatty acid elongase, putative | 0.013 | 0.0491 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0171 | 0.0691 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0147 | 0.0571 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.1003 | 0.4744 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0147 | 0.0571 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0171 | 0.0691 | 1 |
Onchocerca volvulus | 0.0147 | 0.0571 | 0.5 | |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0171 | 0.0691 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0147 | 0.0571 | 0.8171 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0571 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0147 | 0.0571 | 0.8265 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0067 | 0.0182 | 0.2746 |
Entamoeba histolytica | fatty acid elongase, putative | 0.013 | 0.0491 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0147 | 0.0571 | 0.1138 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24863745 | |
Mus musculus | ChEMBL23 | 24863745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.