Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.3568 | 0.3568 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0112 | 0.3087 | 0.3087 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0098 | 0.2426 | 0.2426 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0048 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.3087 | 0.3087 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0048 | 0 | 0.5 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0238 | 0.9225 | 0.9225 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0112 | 0.3087 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0048 | 0 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.3087 | 0.3087 |
Trypanosoma brucei | protein kinase, putative | 0.0048 | 0 | 0.5 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0112 | 0.3087 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.3087 | 0.3087 |
Brugia malayi | hypothetical protein | 0.0122 | 0.3568 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.3087 | 0.3087 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.9225 | 0.9225 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0238 | 0.9225 | 0.9225 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.7167 | 0.7167 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0254 | 1 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0098 | 0.2426 | 0.2426 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0098 | 0.2426 | 0.68 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0048 | 0 | 0.5 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0254 | 1 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0238 | 0.9225 | 0.9225 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.3087 | 0.3087 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0098 | 0.2426 | 0.2426 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.3568 | 0.3568 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 nM | Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP | ChEMBL. | 24984230 |
IC50 (functional) | = 22 nM | Inhibition of LPS-induced TNFalpha release in human PBMC preincubated for 30 mins before LPS stimulation measured after 18 hrs by TR-FRET assay | ChEMBL. | 24984230 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24984230 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.