Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0942 | 0.0942 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0597 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0095 | 0 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0597 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.0942 | 0.0942 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0095 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0095 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0095 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.0089 | 0.0089 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0095 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0095 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0095 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0597 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.0942 | 0.0942 |
Mycobacterium ulcerans | hypothetical protein | 0.0095 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0095 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0095 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0095 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0095 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0597 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0597 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0095 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0095 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0095 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of COX1 in human platelets using arachidonic acid as substrate assessed as residual activity at 50 uM preincubated for 15 mins before substrate addition measured after 10 mins | ChEMBL. | 25036790 | |
Activity (binding) | = 8.6 % | Inhibition of COX2-mediated PGE2 formation in IL1beta/TNFalpha-stimulated human HeLa cells using arachidonic acid as substrate assessed as residual activity at 50 uM measured after 30 mins by ELISA | ChEMBL. | 25036790 |
Activity (binding) | > 70 % | Inhibition of 12-LO-mediated 12-HPETE formation in human platelets using arachidonic acid as substrate assessed as residual activity at 50 uM preincubated for 15 mins before substrate addition measured after 10 mins | ChEMBL. | 25036790 |
Activity (binding) | > 70 % | Inhibition of 15-LO1-mediated 15-HPETE formation in human eosinophil using arachidonic acid as substrate assessed as residual activity at 50 uM preincubated for 15 mins before substrate addition measured after 10 mins | ChEMBL. | 25036790 |
IC50 (binding) | = 0.4 uM | Inhibition of partially purified recombinant 5-lipoxygenase (unknown origin) using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 mins by HPLC analysis | ChEMBL. | 25036790 |
IC50 (binding) | = 5.8 uM | Inhibition of 5-lipoxygenase in human PMNL using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 mins | ChEMBL. | 25036790 |
Inhibition (binding) | Inhibition of human recombinant Sphk1 at 10 uM after 30 mins by ADP2 fluorescence intensity assay | ChEMBL. | 25150091 | |
Inhibition (binding) | Inhibition of human recombinant Sphk2 at 10 uM after 60 mins by ADP2 fluorescence intensity assay | ChEMBL. | 25150091 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.