Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | proteasome subunit beta type 1, putative | proteasome (prosome, macropain) subunit, beta type, 8 | 272 aa | 251 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | proteasome PrcB | 0.0183 | 0.0487 | 0.5 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0844 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0183 | 0.0487 | 0.0487 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0183 | 0.0487 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0183 | 0.0487 | 0.0487 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0183 | 0.0487 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0183 | 0.0487 | 0.5 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0844 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0183 | 0.0487 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0183 | 0.0487 | 0.5 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0844 | 1 | 1 |
Onchocerca volvulus | 0.0768 | 0.8908 | 0.5 | |
Loa Loa (eye worm) | Carm1-pending protein | 0.0844 | 1 | 1 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0844 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0183 | 0.0487 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0183 | 0.0487 | 0.0487 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0183 | 0.0487 | 0.0487 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0183 | 0.0487 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0183 | 0.0487 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0183 | 0.0487 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0183 | 0.0487 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0183 | 0.0487 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 nM | Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry | ChEMBL. | 25006746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.