Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Rattus norvegicus | Purinergic receptor P2Y12 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | neuropeptide receptor | Purinergic receptor P2Y12 | 343 aa | 305 aa | 24.9 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Purinergic receptor P2Y12 | 343 aa | 372 aa | 19.6 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Purinergic receptor P2Y12 | 343 aa | 334 aa | 21.6 % |
Echinococcus granulosus | neuropeptide receptor | Purinergic receptor P2Y12 | 343 aa | 349 aa | 22.6 % |
Schistosoma japonicum | Myosin-XVIIIa, putative | Purinergic receptor P2Y12 | 343 aa | 325 aa | 22.8 % |
Echinococcus multilocularis | rhodopsin orphan GPCR | Purinergic receptor P2Y12 | 343 aa | 347 aa | 20.2 % |
Onchocerca volvulus | Purinergic receptor P2Y12 | 343 aa | 281 aa | 22.8 % | |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Purinergic receptor P2Y12 | 343 aa | 328 aa | 23.5 % |
Echinococcus granulosus | allatostatin A receptor | Purinergic receptor P2Y12 | 343 aa | 337 aa | 21.4 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Purinergic receptor P2Y12 | 343 aa | 359 aa | 20.9 % |
Echinococcus multilocularis | neuropeptide receptor | Purinergic receptor P2Y12 | 343 aa | 325 aa | 23.7 % |
Echinococcus multilocularis | allatostatin A receptor | Purinergic receptor P2Y12 | 343 aa | 337 aa | 21.4 % |
Onchocerca volvulus | Purinergic receptor P2Y12 | 343 aa | 323 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0376 | 0.1983 | 0.1983 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0355 | 0.1856 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.1856 | 0.5 |
Schistosoma mansoni | amidase | 0.0417 | 0.2235 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.005 | 0 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0355 | 0.1856 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0417 | 0.2235 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0355 | 0.1856 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0355 | 0.1856 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0355 | 0.1856 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.1691 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0355 | 0.1856 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0417 | 0.2235 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.2235 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0417 | 0.2235 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0417 | 0.2235 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0355 | 0.1856 | 0.1856 |
Plasmodium vivax | PST-A protein | 0.0355 | 0.1856 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0417 | 0.2235 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0355 | 0.1856 | 0.1856 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0355 | 0.1856 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0355 | 0.1856 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0355 | 0.1856 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0355 | 0.1856 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0355 | 0.1856 | 0.5 |
Brugia malayi | amidase | 0.0417 | 0.2235 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0355 | 0.1856 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.005 | 0 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.005 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0355 | 0.1856 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0355 | 0.1856 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0355 | 0.1856 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0355 | 0.1856 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0376 | 0.1983 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0355 | 0.1856 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 71 nM | Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis | ChEMBL. | 25075638 |
IC50 (binding) | = 1 uM | Antagonist activity at P2Y12 receptor in Sprague-Dawley rat platelet rich plasma assessed as inhibition of ADP-induced aggregation | ChEMBL. | 25075638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.