TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.436 | Formula: C22H22N4O2
H donors: 1 H acceptors: 3 LogP: 4.65 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1noc(c1)C(C)(C)C)Cc1ccc(cc1)c1ccc2n(c1)ccn2
InChi: 1S/C22H22N4O2/c1-22(2,3)18-13-19(25-28-18)24-21(27)12-15-4-6-16(7-5-15)17-8-9-20-23-10-11-26(20)14-17/h4-11,13-14H,12H2,1-3H3,(H,24,25,27)
InChiKey: ODVKEUNDHWFSOX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ret proto-oncogene	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase csk	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0002	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0002	0	0.5
Loa Loa (eye worm)	POT family protein	0.0169	0.7418	0.7418
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0002	0	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0002	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0002	0	0.5
Toxoplasma gondii	STE kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trypanosoma brucei	protein kinase, putative	0.0002	0	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0002	0	0.5
Toxoplasma gondii	protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.0002	0	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0002	0	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	heat shock protein 70	0.0002	0	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0002	0	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0002	0	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0002	0	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0002	0	0.5
Brugia malayi	POT family protein	0.0169	0.7418	0.7418
Trichomonas vaginalis	TK family protein kinase	0.0002	0	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Giardia lamblia	Kinase	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	insulin receptor	0.0002	0	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0002	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0002	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Giardia lamblia	Kinase, NEK	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0002	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0002	0	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0002	0	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0002	0	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Giardia lamblia	Protein 21.1	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0002	0	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0002	0	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Echinococcus granulosus	protein kinase	0.0002	0	0.5
Schistosoma mansoni	ephrin receptor	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0002	0	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0002	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0228	1	1
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0002	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus granulosus	activin receptor type	0.0002	0	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0002	0	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0002	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0002	0	0.5
Giardia lamblia	Kinase, NEK	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0002	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0002	0	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0002	0	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0002	0	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0002	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0002	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0002	0	0.5
Schistosoma mansoni	hypothetical protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0002	0	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0002	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0002	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0785	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0002	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	ephrin receptor	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0002	0	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0002	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0002	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0002	0	0.5
Schistosoma mansoni	serine/threonine RGC	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0002	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus multilocularis	protein kinase	0.0002	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0002	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0002	0	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0002	0	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0002	0	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0002	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0002	0	0.5
Echinococcus multilocularis	tyrosine kinase	0.0002	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine kinase	0.0002	0	0.5
Echinococcus granulosus	insulin receptor	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0002	0	0.5
Echinococcus granulosus	protein tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Plasmodium vivax	protein kinase, putative	0.0002	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Echinococcus multilocularis	protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0002	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0002	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0785	1
Schistosoma mansoni	serine/threonine protein kinase	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Leishmania major	hypothetical protein, conserved	0.0019	0.0785	1
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0002	0	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0002	0	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0002	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Echinococcus multilocularis	activin receptor type	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0002	0	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0002	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0002	0	0.5
Schistosoma mansoni	protein kinase	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0002	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0002	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0002	0	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0002	0	0.5
Onchocerca volvulus		0.0002	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0002	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.21 uM	Inhibition of RET (unknown origin) pre-incubated for 60 mins before substrate addition in presence of 9 uM ATP by microfluidic assay	ChEMBL.	25232968
IC50 (binding)	= 0.25 uM	Inhibition of RET C634R mutant (unknown origin) expressed in rat RAT1 cells assessed as reduction in Tyr905 phosphorylation at 0.5 to 10 uM incubated for 2 hrs by immunoblotting method	ChEMBL.	25232968
IC50 (binding)	= 0.25 uM	Inhibition of RET C634R mutant (unknown origin) expressed in rat RAT1 cells assessed as reduction in Tyr1062 phosphorylation at 0.5 to 10 uM incubated for 2 hrs by immunoblotting method	ChEMBL.	25232968
IC50 (binding)	= 0.38 uM	Inhibition of RET (unknown origin) pre-incubated for 20 mins before substrate addition in presence of 9 uM ATP by microfluidic assay	ChEMBL.	25232968
IC50 (binding)	= 0.42 uM	Inhibition of RET (unknown origin) pre-incubated for 3 mins before substrate addition in presence of 9 uM ATP by microfluidic assay	ChEMBL.	25232968
IC50 (binding)	= 0.44 uM	Inhibition of RET (unknown origin) pre-incubated for 0 mins before substrate addition in presence of 9 uM ATP by microfluidic assay	ChEMBL.	25232968

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3329397

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 927834