Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Starlite/ChEMBL | References |
Rattus norvegicus | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania infantum | hypothetical protein, conserved | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 170 aa | 27.6 % |
Trypanosoma cruzi | hypothetical protein, conserved | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 140 aa | 25.7 % |
Candida albicans | one of three chitinase genes similar to S. cerevisiae CTS1 (YLR286C) | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 146 aa | 22.6 % |
Leishmania mexicana | hypothetical protein, conserved | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 169 aa | 29.0 % |
Leishmania major | hypothetical protein, conserved | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 161 aa | 26.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0035 | 0.0171 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0058 | 0.0303 | 0.0303 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.1617 | 0.192 |
Brugia malayi | Probable ClpP-like protease | 0.0089 | 0.0776 | 0.3829 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0585 | 0.8421 | 0.8421 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 1 |
Onchocerca volvulus | 0.0041 | 0.0035 | 0.5 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0034 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0034 | 0.0041 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0089 | 0.0776 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0392 | 0.5446 | 0.6467 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0089 | 0.0776 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0058 | 0.0303 | 0.3615 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0776 | 0.3829 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0262 | 0.3443 | 1 |
Trypanosoma brucei | nucleoside 2-deoxyribosyltransferase | 0.0322 | 0.4364 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0322 | 0.4364 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0042 | 0.0054 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0035 | 0.0171 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0035 | 0.0171 |
Echinococcus granulosus | neuropeptide s receptor | 0.0392 | 0.5446 | 0.6467 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0585 | 0.8421 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0322 | 0.4364 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0054 | 0.0265 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0035 | 0.0171 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0035 | 0.0171 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0034 | 0.0169 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0392 | 0.5446 | 0.5446 |
Echinococcus granulosus | geminin | 0.0144 | 0.1617 | 0.192 |
Echinococcus granulosus | muscleblind protein | 0.017 | 0.2026 | 0.2406 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0042 | 0.0054 | 0.0265 |
Brugia malayi | Muscleblind-like protein | 0.017 | 0.2026 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0322 | 0.4364 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 0.0922 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0042 | 0.0054 | 0.0265 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0035 | 0.0041 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.2026 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0035 | 0.0171 |
Echinococcus multilocularis | muscleblind protein 1 | 0.017 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0035 | 0.0171 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 0.0776 |
Echinococcus multilocularis | muscleblind protein | 0.017 | 0.2026 | 0.2026 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0034 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0035 | 0.0171 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0089 | 0.0776 | 0.0922 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0585 | 0.8421 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0089 | 0.0776 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0034 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.2026 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0058 | 0.0303 | 0.0786 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0034 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0322 | 0.4364 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0058 | 0.0303 | 0.0359 |
Echinococcus multilocularis | geminin | 0.0144 | 0.1617 | 0.1617 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0035 | 0.0041 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0035 | 0.0171 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0035 | 0.0041 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0034 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0322 | 0.4364 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0392 | 0.5446 | 0.5446 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0089 | 0.0776 | 1 |
Onchocerca volvulus | 0.0041 | 0.0035 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0322 | 0.4364 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.1617 | 0.192 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0322 | 0.4364 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0034 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0035 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0035 | 0.0171 |
Onchocerca volvulus | 0.0041 | 0.0035 | 0.5 | |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0058 | 0.0303 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0035 | 0.0171 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.0776 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.6 uM | Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically | ChEMBL. | 25108359 |
Ki (binding) | = 3.9 uM | Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically | ChEMBL. | 25108359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.