Detailed information for compound 930322

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 535.615 | Formula: C27H29N5O5S
  • H donors: 3 H acceptors: 8 LogP: 3.9 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCOc1nc(nc(c1Cc1ccccc1O)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1
  • InChi: 1S/C27H29N5O5S/c1-27(2,3)19-9-11-20(12-10-19)38(35,36)32-23-21(17-18-7-4-5-8-22(18)34)26(37-16-15-33)31-25(30-23)24-28-13-6-14-29-24/h4-14,33-34H,15-17H2,1-3H3,(H,30,31,32)
  • InChiKey: QOGJFOURIDFEQJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Bile salt export pump Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum ABC transporter C family protein Bile salt export pump   1321 aa 1211 aa 23.0 %
Onchocerca volvulus Bile salt export pump   1321 aa 1321 aa 31.7 %
Brugia malayi ABC transporter transmembrane region family protein Bile salt export pump   1321 aa 1264 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis rotamase, putative 0.0154 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0583 0.0583
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.015 0.9758 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0583 0.0583
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0583 0.0583
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0327 0.0327
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0583 0.0583
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0583 0.0583
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0574 0.0574
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0583 0.0583
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0047 0.2856 0.2926
Loa Loa (eye worm) hypothetical protein 0.0013 0.0583 0.0583
Giardia lamblia MRP-like ABC transporter 0.0004 0 0.5
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.015 0.9758 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0583 0.0583
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0583 0.0583
Schistosoma mansoni multidrug resistance protein 0.0013 0.0583 0.0583
Schistosoma mansoni rotamase 0.0154 1 1
Onchocerca volvulus 0.0013 0.0583 0.5
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.0583 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0583 0.0583
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis abcb9, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis abcb9, putative 0.0013 0.0583 0.0583
Schistosoma mansoni multidrug resistance protein 0.0013 0.0583 0.0583
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0583 0.0598
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0583 0.0583
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0583 0.0583
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0583 0.0583
Brugia malayi ABC transporter family protein 0.0013 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0013 0.0583 0.0583
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0583 1
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0004 0 0.5
Leishmania major p-glycoprotein 0.0013 0.0583 0.0598
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0583 0.0583
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0583 0.0583
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0583 0.0583
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0047 0.2856 0.2926
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.0327 0.0327
Echinococcus multilocularis multidrug resistance protein 1 0.0009 0.0327 0.0327
Trichomonas vaginalis rotamase, putative 0.015 0.9758 0.9758
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0583 0.0583
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0583 0.0583
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0583 0.0583
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0583 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0583 0.0583
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0154 1 1
Echinococcus granulosus expressed protein 0.0154 1 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0583 0.0583
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.015 0.9758 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0583 0.0598
Toxoplasma gondii peptidylprolyl isomerase 0.015 0.9758 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0047 0.2856 0.2926
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0583 0.0583
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0047 0.2856 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0583 0.0598
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0583 0.0598
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0583 0.0583
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0574 0.0574
Echinococcus multilocularis expressed protein 0.0154 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0583 0.0583
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0583 0.0583
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0 0.5
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0583 0.0598
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0583 0.0583
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0583 0.0598
Schistosoma mansoni multidrug resistance protein 0.0013 0.0583 0.0583
Giardia lamblia ABC transporter, putative 0.0004 0 0.5
Schistosoma mansoni smdr2 0.0013 0.0583 0.0583
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0583 0.0583
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0583 0.0598
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0154 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0583 0.0583
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0583 0.0583
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0583 0.0598
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0583 0.0598
Trichomonas vaginalis abcb9, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0583 0.0583
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.015 0.9758 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0583 0.0598
Trichomonas vaginalis taga, putative 0.0013 0.0583 0.0583
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0 0.5
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0047 0.2856 0.2926
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.015 0.9758 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0583 0.0583
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0047 0.2856 0.2926
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0583 0.0583
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0327 0.0327
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0004 0 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0583 0.0583
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0013 0.0574 0.0574
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.0583 0.5
Brugia malayi multidrug resistance protein 3 0.0013 0.0583 0.0583

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 8.5 uM TP_TRANSPORTER: inhibition of Taurocholate uptake in membrane vesicle from Bsep-expressing Sf9-cell ChEMBL. 11309550

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.