Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.006 | 0.006 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.054 | 0.7657 | 0.7657 |
Schistosoma mansoni | carbonic anhydrase | 0.035 | 0.4942 | 0.4912 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.4942 | 0.4942 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0703 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.035 | 0.4942 | 0.4912 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.006 | 0.006 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.035 | 0.4942 | 0.4942 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.006 | 0.006 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.006 | 0.006 |
Schistosoma mansoni | carbonic anhydrase-related | 0.035 | 0.4942 | 0.4912 |
Schistosoma mansoni | serine/threonine protein kinase | 0.054 | 0.7657 | 0.7643 |
Toxoplasma gondii | hypothetical protein | 0.035 | 0.4942 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.006 | 0.006 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.035 | 0.4942 | 0.4942 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0282 | 0.3967 | 0.393 |
Echinococcus multilocularis | carbonic anhydrase | 0.035 | 0.4942 | 0.4912 |
Echinococcus multilocularis | carbonic anhydrase | 0.035 | 0.4942 | 0.4912 |
Leishmania major | carbonic anhydrase-like protein | 0.0703 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.035 | 0.4942 | 0.4942 |
Entamoeba histolytica | protein kinase, putative | 0.0282 | 0.3967 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.1911 | 0.1911 |
Echinococcus granulosus | carbonic anhydrase | 0.035 | 0.4942 | 0.4912 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0282 | 0.3967 | 0.393 |
Brugia malayi | Smad1 | 0.0009 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.4942 | 0.4942 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0703 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0703 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.1911 | 0.1911 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.4942 | 0.4912 |
Entamoeba histolytica | protein kinase, putative | 0.0282 | 0.3967 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.035 | 0.4942 | 0.4912 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.1911 | 0.1911 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.4942 | 0.4942 |
Echinococcus granulosus | carbonic anhydrase | 0.035 | 0.4942 | 0.4912 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0703 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0282 | 0.3966 | 0.3929 |
Schistosoma mansoni | carbonic anhydrase-related | 0.035 | 0.4942 | 0.4912 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.006 | 0.006 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.035 | 0.4942 | 0.4942 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.035 | 0.4942 | 0.4942 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0703 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0282 | 0.3967 | 0.393 |
Echinococcus granulosus | carbonic anhydrase II | 0.0703 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0703 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0703 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0703 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0282 | 0.3966 | 0.3929 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.035 | 0.4942 | 0.4942 |
Plasmodium falciparum | carbonic anhydrase | 0.035 | 0.4942 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.006 | 0.006 |
Brugia malayi | Protein kinase domain containing protein | 0.054 | 0.7657 | 0.7657 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0703 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.035 | 0.4942 | 0.4912 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 44 % | TP_TRANSPORTER: inhibition of DNP-SG uptake (DNP-SG: 10 uM, 4-Glutathionyl cyclophosphamide: 1000uM) in membrane vesicles from S1(MRP) cells | ChEMBL. | 8706899 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.