TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 306.787 | Formula: C16H19ClN2O2
H donors: 1 H acceptors: 1 LogP: 3.25 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1Cl)CNCC(Oc1ccccn1)C
InChi: 1S/C16H19ClN2O2/c1-12(21-16-5-3-4-8-19-16)10-18-11-13-6-7-15(20-2)14(17)9-13/h3-9,12,18H,10-11H2,1-2H3
InChiKey: BWHTXUCMKWQCDJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0038	0.0539	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0052	0.0052
Echinococcus multilocularis	cathepsin L	0.0021	0.0087	0.0087
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.0578	0.0951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.004	0.0578	0.0578
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0036	0.0487	0.0487
Schistosoma mansoni	glycogen phosphorylase	0.0223	0.5253	0.5253
Brugia malayi	cathepsin L-like precursor	0.0027	0.0243	0.0243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0043	0.0666	0.044
Schistosoma mansoni	ap endonuclease	0.0045	0.0703	0.0703
Echinococcus granulosus	cathepsin L cysteine protease	0.0021	0.0087	0.0087
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Chlamydia trachomatis	glycogen phosphorylase	0.0223	0.5253	0.5
Echinococcus multilocularis	aldo keto reductase	0.0038	0.0539	0.0539
Echinococcus granulosus	aldo keto reductase	0.0038	0.0539	0.0539
Trichomonas vaginalis	aldo/keto reductase, putative	0.0038	0.0539	0.0875
Leishmania major	cysteine peptidase A (CPA)	0.004	0.0578	0.0136
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.0487	0.0487
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0045	0.0703	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0487
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0045	0.0703	0.1105
Echinococcus multilocularis	aldo keto reductase	0.0038	0.0539	0.0539
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0043	0.0666	0.0269
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0043	0.0666	0.0666
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.0487	0.0487
Echinococcus multilocularis	cysteine protease	0.004	0.0578	0.0578
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0036	0.0487	0.0487
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.0487	0.0487
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0021	0.0087	0.0087
Brugia malayi	Steroid receptor seven-up type 2	0.0036	0.0487	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Onchocerca volvulus		0.004	0.0578	0.1101
Echinococcus multilocularis	glycogen phosphorylase	0.0223	0.5253	0.5253
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Onchocerca volvulus		0.0038	0.0539	0.1026
Echinococcus granulosus	Glycosyl transferase family 35	0.0223	0.5253	0.5253
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0021	0.0087	0.0087
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0036	0.0487	0.0487
Brugia malayi	nuclear receptor RXR	0.0019	0.0052	0.0052
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0487	0.0487
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0045	0.0703	0.1845
Trichomonas vaginalis	ap endonuclease, putative	0.0045	0.0703	0.1193
Leishmania major	cathepsin L-like protease	0.004	0.0578	0.0136
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0036	0.0487	0.0487
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Trypanosoma cruzi	aldo-keto reductase	0.0038	0.0539	0.1354
Brugia malayi	Papain family cysteine protease containing protein	0.0021	0.0087	0.0087
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0487	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0539	0.0539
Echinococcus granulosus	glycogen phosphorylase	0.0223	0.5253	0.5253
Brugia malayi	Papain family cysteine protease containing protein	0.004	0.0578	0.0578
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0045	0.0703	0.1845
Echinococcus multilocularis	cathepsin L cysteine protease	0.004	0.0578	0.0578
Loa Loa (eye worm)	glycogen phosphorylase	0.0223	0.5253	0.5253
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.0487	0.0487
Leishmania major	cathepsin L-like protease	0.0152	0.3426	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0487
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0666	0.1734
Schistosoma mansoni	ap endonuclease	0.0045	0.0703	0.0703
Brugia malayi	hypothetical protein	0.0019	0.0052	0.0052
Onchocerca volvulus	Bile acid receptor homolog	0.0036	0.0487	0.0928
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0045	0.0703	0.1845
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0038	0.0539	0.0875
Schistosoma mansoni	pol-related	0.0038	0.0539	0.0539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0487
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.004	0.0578	0.0578
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0036	0.0487	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.004	0.0578	0.0951
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Plasmodium vivax	vivapain-2	0.004	0.0578	0.7974
Entamoeba histolytica	glycogen phosphorylase, putative	0.0223	0.5253	1
Brugia malayi	Cathepsin L-like precursor	0.004	0.0578	0.0578
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0045	0.0703	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0036	0.0487	0.0487
Brugia malayi	steroid hormone receptor	0.0036	0.0487	0.0487
Entamoeba histolytica	aldose reductase, putative	0.0038	0.0539	0.0875
Trypanosoma brucei	aldo-keto reductase, putative	0.0038	0.0539	0.1354
Echinococcus granulosus	ubiquitin specific protease 41	0.0043	0.0666	0.0666
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0243	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0036	0.0487	0.0487
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0539	0.0539
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0666	0.1121
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Loa Loa (eye worm)	steroid hormone receptor	0.0036	0.0487	0.0487
Brugia malayi	Cathepsin L-like precursor	0.004	0.0578	0.0578
Loa Loa (eye worm)	oxidoreductase	0.0038	0.0539	0.0539
Toxoplasma gondii	exonuclease III APE	0.0045	0.0703	1
Onchocerca volvulus		0.0036	0.0487	0.0928
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0043	0.0666	0.0666
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Giardia lamblia	Glycogen phosphorylase	0.0223	0.5253	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0036	0.0487	0.0487
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0223	0.5253	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0043	0.0666	0.0666
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0045	0.0703	0.0569
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0019	0.0052	0.0052
Echinococcus multilocularis	aldehyde reductase	0.0027	0.0257	0.0257
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Onchocerca volvulus		0.004	0.0578	0.1101
Echinococcus granulosus	glycogen phosphorylase	0.0223	0.5253	0.5253
Trypanosoma cruzi	cysteine peptidase, putative	0.004	0.0578	0.1472
Onchocerca volvulus	Cathepsin L homolog	0.004	0.0578	0.1101
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Leishmania major	cathepsin L-like protease	0.004	0.0578	0.0136
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0036	0.0487	0.0928
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0019	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0487
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.0487	0.0487
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0038	0.0539	0.0875
Brugia malayi	Cathepsin L-like precursor	0.004	0.0578	0.0578
Onchocerca volvulus		0.004	0.0578	0.1101
Leishmania major	cathepsin L-like protease	0.004	0.0578	0.0136
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0036	0.0487	0.0487
Loa Loa (eye worm)	oxidoreductase	0.0038	0.0539	0.0539
Onchocerca volvulus		0.0038	0.0539	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0487
Echinococcus granulosus	ecdysone induced protein 78C	0.0036	0.0487	0.0487
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.041	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0052	0.0052
Trypanosoma brucei	prostaglandin f synthase	0.0038	0.0539	0.1354
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0666	0.1734
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.041	1	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.0666	0.1121
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0045	0.0703	0.0703
Entamoeba histolytica	cysteine protease, putative	0.004	0.0578	0.0951
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0045	0.0703	0.0703
Leishmania major	cathepsin L-like protease	0.0152	0.3426	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0223	0.5253	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.0487	0.0487
Onchocerca volvulus		0.004	0.0578	0.1101
Echinococcus multilocularis	cysteine protease	0.004	0.0578	0.0578
Brugia malayi	photoreceptor-specific nuclear receptor	0.0036	0.0487	0.0487
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Echinococcus granulosus	cathepsin l cysteine peptidase	0.004	0.0578	0.0578
Trypanosoma cruzi	major cysteine proteinase, putative	0.0119	0.26	0.7525
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0036	0.0487	0.0487
Entamoeba histolytica	aldose reductase, putative	0.0038	0.0539	0.0875
Onchocerca volvulus		0.0038	0.0539	0.1026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0052	0.0052
Brugia malayi	Cathepsin L-like precursor	0.004	0.0578	0.0578
Loa Loa (eye worm)	oxidoreductase	0.0038	0.0539	0.0539
Entamoeba histolytica	glycogen phosphorylase, putative	0.0097	0.2024	0.375
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.0666	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0487
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0045	0.0703	0.0348
Schistosoma mansoni	aldo-keto reductase	0.0038	0.0539	0.0539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.0666	0.0666
Loa Loa (eye worm)	cysteine protease	0.004	0.0578	0.0578
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0138	0.3091	0.8997
Trichomonas vaginalis	ap endonuclease, putative	0.0045	0.0703	0.1193
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Echinococcus multilocularis	aldo keto reductase	0.0038	0.0539	0.0539
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0036	0.0487	0.0487
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0045	0.0703	0.1105
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.0487	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0487
Schistosoma mansoni	aldo-keto reductase	0.0038	0.0539	0.0539
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0036	0.0487	0.0487
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0036	0.0487	0.0487
Brugia malayi	nuclear receptor NHR-88	0.0036	0.0487	0.0487
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0036	0.0487	0.0487
Onchocerca volvulus	Cathepsin L homolog	0.004	0.0578	0.1101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0539	0.0539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0487	0.0487
Echinococcus granulosus	aldo keto reductase	0.0038	0.0539	0.0539
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0043	0.0666	0.0666
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.0487	0.0487
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0243	0.0243
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.0487	0.0487
Onchocerca volvulus		0.0038	0.0539	0.1026
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0036	0.0487	0.0487
Trichomonas vaginalis	aldo/keto reductase, putative	0.0038	0.0539	0.0875
Echinococcus granulosus	cathepsin L	0.0021	0.0087	0.0087
Schistosoma mansoni	glycogen phosphorylase	0.0097	0.2024	0.2024
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.004	0.0578	0.7974
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0666	0.1734
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Schistosoma mansoni	retinoic acid receptor RXR	0.0036	0.0487	0.0487
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0487	0.0487
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0036	0.0487	0.0487
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0036	0.0487	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0487	0.0487
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0036	0.0487	0.0487
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0097	0.2024	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0019	0.0052	0.0052
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0019	0.0052	0.0052
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.041	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0052	0.0052
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.004	0.0578	0.0578
Brugia malayi	Papain family cysteine protease containing protein	0.0021	0.0087	0.0087
Echinococcus multilocularis	ecdysone induced protein 78C	0.0036	0.0487	0.0487
Leishmania major	cathepsin L-like protease	0.0152	0.3426	1
Echinococcus granulosus	cathepsin l1	0.0027	0.0243	0.0243
Leishmania major	cathepsin L-like protease	0.004	0.0578	0.0136
Schistosoma mansoni	cathepsin F (C01 family)	0.004	0.0578	0.0578
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0045	0.0703	0.0703
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0043	0.0666	0.1121
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0052	0.0052
Entamoeba histolytica	glycogen phosphorylase, putative	0.0097	0.2024	0.375
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0045	0.0703	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.004	0.0578	0.0578
Brugia malayi	carbohydrate phosphorylase	0.0223	0.5253	0.5253
Onchocerca volvulus		0.004	0.0578	0.1101
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0036	0.0487	0.0487
Trypanosoma cruzi	cysteine peptidase, putative	0.0152	0.3426	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0036	0.0487	0.0487
Onchocerca volvulus	Protein ultraspiracle homolog	0.0036	0.0487	0.0928
Loa Loa (eye worm)	ctsf protein	0.004	0.0578	0.0578
Entamoeba histolytica	aldose reductase, putative	0.0038	0.0539	0.0875
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0243	0.0243
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0052	0.0052
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0036	0.0487	0.0487
Trichomonas vaginalis	aldo/keto reductase, putative	0.0038	0.0539	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0666	0.0666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Brugia malayi	Cathepsin L-like precursor	0.004	0.0578	0.0578
Onchocerca volvulus		0.004	0.0578	0.1101
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0223	0.5253	1
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.0578	0.0951
Loa Loa (eye worm)	fibroinase	0.004	0.0578	0.0578
Onchocerca volvulus		0.0038	0.0539	0.1026
Toxoplasma gondii	cathepsin CPL	0.004	0.0578	0.2395
Schistosoma mansoni	coup transcription factor	0.0036	0.0487	0.0487
Onchocerca volvulus		0.0027	0.0243	0.0463
Brugia malayi	nuclear hormone receptor	0.0036	0.0487	0.0487
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Echinococcus multilocularis	aldo keto reductase	0.0038	0.0539	0.0539
Echinococcus granulosus	FTZ F1 alpha	0.0036	0.0487	0.0487
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0036	0.0487	0.0487
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0043	0.0666	0.0666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Echinococcus multilocularis	FTZ F1 alpha	0.0036	0.0487	0.0487
Onchocerca volvulus		0.0038	0.0539	0.1026
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0243	0.0243
Schistosoma mansoni	cathepsin F (C01 family)	0.004	0.0578	0.0578
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0045	0.0703	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Echinococcus granulosus	cysteine protease	0.0021	0.0087	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.0487	0.0487
Echinococcus granulosus	cathepsin l1	0.004	0.0578	0.0578
Entamoeba histolytica	glycogenphosphorylase, putative	0.0097	0.2024	0.375
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0027	0.0243	0.0243
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.004	0.0578	0.7974
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0243	0.0303
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.0666	0.1121
Loa Loa (eye worm)	hypothetical protein	0.004	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0243	0.0243
Echinococcus multilocularis	glycogen phosphorylase	0.0223	0.5253	0.5253
Plasmodium falciparum	cysteine proteinase falcipain 3	0.004	0.0578	0.7974
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.041	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0036	0.0487	0.0487
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0223	0.5253	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0243	0.0303
Trypanosoma cruzi	cysteine peptidase, putative	0.0152	0.3426	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0578	0.0951
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0036	0.0487	0.0487
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0097	0.2024	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Echinococcus granulosus	cathepsin L cysteine proteinase	0.004	0.0578	0.0578
Schistosoma mansoni	RAR-like nuclear receptor	0.0036	0.0487	0.0487
Echinococcus granulosus	hypothetical protein	0.0038	0.0539	0.0539
Brugia malayi	Cathepsin L-like precursor	0.004	0.0578	0.0578
Schistosoma mansoni	glycogen phosphorylase	0.0223	0.5253	0.5253
Trypanosoma cruzi	cysteine peptidase, putative	0.0152	0.3426	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0539	0.0539
Echinococcus granulosus	aldo keto reductase	0.0038	0.0539	0.0539
Onchocerca volvulus	Cathepsin F homolog	0.004	0.0578	0.1101
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0539	0.0875
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0036	0.0487	0.0487
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0043	0.0666	0.0666
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0021	0.0087	0.0087
Brugia malayi	ecdysteroid receptor	0.0036	0.0487	0.0487
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Trypanosoma cruzi	aldo/keto reductase, putative	0.0038	0.0539	0.1354
Loa Loa (eye worm)	oxidoreductase	0.0038	0.0539	0.0539
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0036	0.0487	0.0487
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0045	0.0703	0.1193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.004	0.0578	0.0951
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0539	0.0539
Echinococcus granulosus	aldehyde reductase	0.0027	0.0257	0.0257
Brugia malayi	exodeoxyribonuclease III family protein	0.0045	0.0703	0.0703
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0223	0.5253	0.5253
Loa Loa (eye worm)	oxidoreductase	0.0038	0.0539	0.0539
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0539	0.0539
Brugia malayi	hypothetical protein	0.0019	0.0052	0.0052
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0036	0.0487	0.0487
Plasmodium vivax	vivapain-2	0.004	0.0578	0.7974
Leishmania major	cathepsin L-like protease	0.004	0.0578	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.004	0.0578	0.0951
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0038	0.0539	0.0875
Echinococcus multilocularis	cathepsin L cysteine protease	0.004	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0052	0.0052
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0036	0.0487	0.0487
Onchocerca volvulus		0.004	0.0578	0.1101
Trypanosoma cruzi	cruzipain precursor, putative	0.0152	0.3426	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0243	0.0243
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0539	0.0539
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0036	0.0487	0.0487
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0036	0.0487	0.0487
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0152	0.3426	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0052	0.0052
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.0487	0.0487

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3547925

Bibliographic References

No literature references available for this target.

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Detailed information for compound 931919