Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0316 | 0.0253 | 0.0039 |
Schistosoma mansoni | tyrosine kinase | 0.0525 | 0.1055 | 0.3117 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0988 | 0.2825 | 0.4194 |
Echinococcus multilocularis | conserved hypothetical protein | 0.2832 | 0.9888 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0531 | 0.1076 | 0.32 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0531 | 0.1076 | 0.0845 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0249 | 0 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.1921 | 0.6398 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1921 | 0.6398 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0988 | 0.2825 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0531 | 0.1076 | 0.0845 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1921 | 0.6398 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0249 | 0 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0531 | 0.1076 | 0.089 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1921 | 0.6398 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1921 | 0.6398 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0316 | 0.0253 | 0.0039 |
Schistosoma mansoni | tyrosine kinase | 0.0525 | 0.1055 | 0.3117 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0249 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1921 | 0.6398 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0988 | 0.2825 | 1 |
Brugia malayi | Serotonin receptor | 0.1918 | 0.6386 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0525 | 0.1055 | 0.3117 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0249 | 0 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0988 | 0.2825 | 0.2639 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1921 | 0.6398 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0531 | 0.1076 | 0.32 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1921 | 0.6398 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0988 | 0.2825 | 0.2698 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0249 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 6.8 uM | Growth inhibition of human HeLa cells after 48 hrs by SRB assay | ChEMBL. | 25264072 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.