TDR Targets

Basic information

Technical information

TDR Targets ID: 934289
Name: (2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9- yl]-5-(ethylaminomethyl)oxolane-3,4-diol
MW: 362.427 | Formula: C17H26N6O3
H donors: 4 H acceptors: 5 LogP: 0.65 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCNC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1
InChi: 1S/C17H26N6O3/c1-2-18-7-11-13(24)14(25)17(26-11)23-9-21-12-15(19-8-20-16(12)23)22-10-5-3-4-6-10/h8-11,13-14,17-18,24-25H,2-7H2,1H3,(H,19,20,22)/t11-,13-,14-,17-/m1/s1
InChiKey: HKTNLVDKFGPCQD-LSCFUAHRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(ethylaminomethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9-purinyl]-5-(ethylaminomethyl)tetrahydrofuran-3,4-diol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Adenosine A1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Adenosine A1 receptor	326 aa	321 aa	22.7 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Adenosine A1 receptor	326 aa	321 aa	23.1 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Adenosine A1 receptor	326 aa	327 aa	24.8 %
Schistosoma mansoni	dro/myosuppressin receptor	Adenosine A1 receptor	326 aa	326 aa	22.1 %
Onchocerca volvulus	Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog	Adenosine A1 receptor	326 aa	286 aa	22.7 %
Echinococcus granulosus	neuropeptide receptor	Adenosine A1 receptor	326 aa	299 aa	22.4 %
Loa Loa (eye worm)	hypothetical protein	Adenosine A1 receptor	326 aa	300 aa	24.3 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	304 aa	21.1 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	311 aa	21.2 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	323 aa	20.7 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	315 aa	21.6 %
Loa Loa (eye worm)	neuropeptide F receptor	Adenosine A1 receptor	326 aa	316 aa	19.9 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	274 aa	22.6 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Adenosine A1 receptor	326 aa	286 aa	26.9 %
Echinococcus multilocularis	allatostatin A receptor	Adenosine A1 receptor	326 aa	303 aa	24.1 %
Brugia malayi	hypothetical protein	Adenosine A1 receptor	326 aa	305 aa	21.0 %
Echinococcus multilocularis	neuropeptide receptor	Adenosine A1 receptor	326 aa	299 aa	22.4 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Adenosine A1 receptor	326 aa	295 aa	28.1 %
Echinococcus granulosus	allatostatin A receptor	Adenosine A1 receptor	326 aa	303 aa	24.1 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	317 aa	24.6 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	306 aa	21.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus granulosus	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Brugia malayi	G protein-coupled receptor F59B2.13	0.0473	0.0814	0.0814
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.4515	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Brugia malayi	putative neuropeptide receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0473	0.0814	0.0814
Echinococcus multilocularis	allatostatin A receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus granulosus	tm gpcr rhodopsin	0.0473	0.0814	0.0814
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0473	0.0814	0.0814
Echinococcus multilocularis	fmrfamide receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	biogenic amine receptor	0.0473	0.0814	0.0814
Brugia malayi	G-protein coupled receptor	0.0473	0.0814	0.0814
Trypanosoma brucei	btb/poz domain containing protein, putative	0.0115	0	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0214	0.0225	0.0225
Onchocerca volvulus		0.0473	0.0814	1
Schistosoma mansoni	neuropeptide receptor	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	opsin-like receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	shaker cognate	0.0214	0.0225	0.0225
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0473	0.0814	0.0814
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Trypanosoma brucei	potassium voltage-gated channel, putative	0.0115	0	0.5
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0214	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	sulfakinin receptor protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0214	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Trypanosoma cruzi	btb/poz domain containing protein, putative	0.0115	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.2629	0.5713	0.5713
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	amine GPCR	0.0473	0.0814	0.0814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Echinococcus granulosus	7TM GPCR rhodopsin	0.0473	0.0814	0.0814
Schistosoma mansoni	amine GPCR	0.0473	0.0814	0.0814
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	neuropeptide F-like receptor	0.0473	0.0814	0.0814
Brugia malayi	larval opioid receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	serotonin receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Leishmania major	hypothetical protein, conserved	0.0115	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	neuropeptide Y receptor	0.0473	0.0814	0.0814
Brugia malayi	AKH receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	neuropeptide Y receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	adenoreceptor	0.0473	0.0814	0.0814
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	neuropeptide F receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	G protein coupled receptor 139	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus granulosus	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0473	0.0814	0.0814
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	ORL1-like opioid receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	g protein coupled receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.2629	0.5713	0.5713
Echinococcus multilocularis	orexin receptor type 2	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	G-protein coupled receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	G-protein coupled receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus granulosus	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus multilocularis	transfer RNA-Gly	0.0214	0.0225	0.0225
Echinococcus multilocularis	potassium voltage gated channel protein	0.0214	0.0225	0.0225
Schistosoma mansoni	amine GPCR	0.0473	0.0814	0.0814
Trypanosoma cruzi	btb/poz domain containing protein, putative	0.0115	0	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0473	0.0814	0.0814
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.4515	1	1
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0473	0.0814	0.0814
Brugia malayi	Dopamine receptor protein 1	0.0473	0.0814	0.0814
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0473	0.0814	0.0814
Schistosoma mansoni	voltage-gated potassium channel	0.0214	0.0225	0.0225
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	voltage gated potassium channel	0.0214	0.0225	0.0225
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0214	0.0225	0.0225
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	g protein coupled receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	myosin xvIII	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	amine GPCR	0.0473	0.0814	0.0814
Echinococcus multilocularis	shaker cognate	0.0214	0.0225	0.0225
Echinococcus multilocularis	g-protein coupled receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	histamine h1 receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	potassium voltage gated channel protein	0.2629	0.5713	0.5713
Trypanosoma cruzi	btb/poz domain containing protein, putative	0.0115	0	0.5
Onchocerca volvulus		0.0473	0.0814	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Trypanosoma brucei	btb/poz domain containing protein, putative	0.0115	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0473	0.0814	0.0814
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0473	0.0814	0.0814
Brugia malayi	RE15519p	0.0473	0.0814	0.0814
Echinococcus granulosus	neuropeptide FF receptor 2	0.0473	0.0814	0.0814
Echinococcus granulosus	allatostatin A receptor	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Onchocerca volvulus		0.0473	0.0814	1
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Trypanosoma cruzi	btb/poz domain containing protein, putative	0.0115	0	0.5
Echinococcus granulosus	voltage gated potassium channel	0.0214	0.0225	0.0225
Echinococcus granulosus	biogenic amine 5HT receptor	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	serotonin receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	7tm_1 domain containing protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	voltage-gated potassium channel	0.0214	0.0225	0.0225
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0473	0.0814	0.0814
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Toxoplasma gondii	K+ channel tetramerisation domain-containing protein	0.0115	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Schistosoma mansoni	vesicular amine transporter	0.0214	0.0225	0.0225
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0214	0.0225	0.0225
Echinococcus granulosus	dro:myosuppressin receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	potassium voltage gated channel protein	0.0214	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.4515	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0473	0.0814	0.0814
Leishmania major	hypothetical protein, conserved	0.0115	0	0.5
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.029	0.0397	0.5
Echinococcus granulosus	g protein coupled receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0214	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	voltage-gated potassium channel	0.2629	0.5713	0.5713
Trypanosoma cruzi	hypothetical protein, conserved	0.0115	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0473	0.0814	0.0814
Loa Loa (eye worm)	melatonin receptor type 1A	0.0473	0.0814	0.0814
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Echinococcus multilocularis	sex peptide receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	neuropeptides capa receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus multilocularis	serotonin receptor	0.0473	0.0814	0.0814
Treponema pallidum	DNA ligase (lig)	0.0164	0.0112	0.5
Echinococcus granulosus	potassium voltage gated channel protein	0.2629	0.5713	0.5713
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0473	0.0814	0.0814
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.4515	1	1
Echinococcus granulosus	sex peptide receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0473	0.0814	0.0814
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.2629	0.5713	0.5713
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus granulosus	biogenic amine 5HT receptor	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Schistosoma mansoni	voltage-gated potassium channel	0.0214	0.0225	0.0225
Echinococcus multilocularis	somatostatin receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0214	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0473	0.0814	1
Brugia malayi	GnHR receptor homolog	0.0473	0.0814	0.0814
Brugia malayi	Dopamine receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	neuropeptide s receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	neuropeptide receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	neuropeptide Y receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0214	0.0225	0.0225
Onchocerca volvulus		0.0473	0.0814	1
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Trypanosoma brucei	btb/poz domain containing protein, putative	0.0115	0	0.5
Leishmania major	hypothetical protein, conserved	0.0115	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0473	0.0814	0.0814
Schistosoma mansoni	neuropeptide f receptor 76f	0.0473	0.0814	0.0814
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0473	0.0814	0.0814
Trypanosoma brucei	btb/poz domain containing protein, putative	0.0115	0	0.5
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	neuropeptide receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus granulosus	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus multilocularis	neuropeptide receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0473	0.0814	0.0814
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0214	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	voltage-gated potassium channel	0.0214	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus multilocularis	potassium voltage gated channel protein	0.0214	0.0225	0.0225
Trypanosoma brucei	potassium voltage-gated channel, putative	0.0115	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Echinococcus multilocularis	dro:myosuppressin receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	neuropeptide receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	tm gpcr rhodopsin	0.0473	0.0814	0.0814
Echinococcus granulosus	somatostatin receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0473	0.0814	0.0814
Brugia malayi	Dopamine receptor protein 2	0.0473	0.0814	0.0814
Schistosoma mansoni	growth hormone secretagogue receptor	0.0473	0.0814	0.0814
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0473	0.0814	0.0814
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.029	0.0397	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Echinococcus granulosus	g-protein coupled receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	amine GPCR	0.0473	0.0814	0.0814
Echinococcus multilocularis	neuropeptide receptor A26	0.0473	0.0814	0.0814
Loa Loa (eye worm)	neuropeptide F receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0473	0.0814	0.0814
Trypanosoma cruzi	btb/poz domain containing protein, putative	0.0115	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Echinococcus granulosus	G protein coupled receptor 139	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Schistosoma mansoni	voltage-gated potassium channel	0.0214	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.2514	0.5452	0.5452
Echinococcus granulosus	neuropeptide receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0473	0.0814	0.0814
Schistosoma mansoni	DNA ligase NAD-dependent	0.026	0.033	0.033
Echinococcus granulosus	neuropeptide receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	g protein coupled receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	neuropeptide Y receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	biogenic amine receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0473	0.0814	0.0814
Toxoplasma gondii	kelch repeat and K+ channel tetramerisation domain containing protein	0.0115	0	0.5
Schistosoma mansoni	hypothetical protein	0.0473	0.0814	0.0814
Leishmania major	potassium voltage-gated channel, putative	0.0115	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0473	0.0814	0.0814
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0473	0.0814	0.0814
Plasmodium vivax	kelch protein K13, putative	0.0115	0	0.5
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.014	0.0058	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Loa Loa (eye worm)	neuropeptide F receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0473	0.0814	0.0814
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0473	0.0814	0.0814
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0214	0.0225	0.0225
Schistosoma mansoni	voltage-gated potassium channel	0.0214	0.0225	0.0225
Echinococcus granulosus	neuropeptide s receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0225	0.0225
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	hypothetical protein	0.0473	0.0814	0.0814
Chlamydia trachomatis	DNA ligase	0.0171	0.0129	0.5
Schistosoma mansoni	hypothetical protein	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Brugia malayi	G-protein coupled receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	g protein coupled receptor	0.0473	0.0814	0.0814
Trypanosoma cruzi	potassium voltage-gated channel, putative	0.0115	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0473	0.0814	0.0814
Brugia malayi	G protein-coupled receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0473	0.0814	0.0814
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0473	0.0814	1
Brugia malayi	Melatonin receptor type 1A	0.0473	0.0814	0.0814
Plasmodium vivax	K+ channel tetramerisation domain containing protein	0.0115	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0473	0.0814	0.0814
Onchocerca volvulus		0.0473	0.0814	1
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Trypanosoma brucei	BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative	0.0115	0	0.5
Brugia malayi	neuropeptide F receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	orexin receptor type 2	0.0473	0.0814	0.0814
Schistosoma mansoni	voltage-gated potassium channel	0.2629	0.5713	0.5713
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0473	0.0814	0.0814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	biogenic amine receptor	0.0473	0.0814	0.0814
Loa Loa (eye worm)	TYRA-2 protein	0.0473	0.0814	0.0814
Schistosoma mansoni	opsin-like receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0473	0.0814	0.0814
Schistosoma mansoni	opsin-like receptor	0.0473	0.0814	0.0814
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Trypanosoma cruzi	potassium voltage-gated channel	0.0115	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Plasmodium falciparum	kelch protein K13	0.0115	0	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0473	0.0814	0.0814
Echinococcus granulosus	fmrfamide receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	rhodopsin orphan GPCR	0.0473	0.0814	0.0814
Echinococcus multilocularis	g protein coupled receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	neuropeptide receptor A26	0.0473	0.0814	0.0814
Echinococcus multilocularis	neuropeptide receptor	0.0473	0.0814	0.0814
Brugia malayi	Serotonin receptor	0.0473	0.0814	0.0814
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0115	0	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0473	0.0814	0.0814
Schistosoma mansoni	voltage-gated potassium channel	0.0214	0.0225	0.0225
Brugia malayi	Serotonin receptor	0.0473	0.0814	0.0814
Brugia malayi	putative neuropeptide receptor NPR1	0.0473	0.0814	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0814	0.0814
Trypanosoma cruzi	btb/poz domain containing protein, putative	0.0115	0	0.5
Brugia malayi	hypothetical protein	0.0473	0.0814	0.0814
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0473	0.0814	0.0814
Echinococcus multilocularis	fmrfamide receptor	0.0473	0.0814	0.0814
Echinococcus granulosus	tm gpcr rhodopsin	0.0473	0.0814	0.0814

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	%	Intrinsic activity for maximum stimulation of [35S]GTPgammaS binding to adenosine A1 receptor in rat brain membranes; '-' means Not determined	ChEMBL.	9438026
EC50 (functional)	nM	Effective concentration for [35S]GTPgammaS binding to adenosine A1 receptor in rat brain membranes; '-' means Not determined	ChEMBL.	9438026
Ki (binding)	= 2410 nM	Binding affinity against adenosine A1 receptor using [3H]-DPCPX in rat cortical membranes in the absence of GTP	ChEMBL.	9438026
Ki (binding)	= 8560 nM	Binding affinity against adenosine A1 receptor using [3H]-DPCPX in rat cortical membranes in the presence of GTP.	ChEMBL.	9438026
Ki (binding)	= 42.5 uM	Binding affinity against Adenosine A2A receptor using [3H]-CGS- 21680 as the radioligand in rat striatal membranes	ChEMBL.	9438026

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2113466

Bibliographic References

No literature references available for this target.

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Detailed information for compound 934289