Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0097 | 0.0315 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0097 | 0.0315 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0097 | 0.0315 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0097 | 0.0315 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0097 | 0.0315 | 0.0315 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0191 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0097 | 0.0315 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0191 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0097 | 0.0315 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0097 | 0.0315 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0097 | 0.0315 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0097 | 0.0315 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0191 | 1 | 1 |
Onchocerca volvulus | 0.0191 | 1 | 0.5 | |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0097 | 0.0315 | 0.0315 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0191 | 1 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.0191 | 1 | 1 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0191 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0097 | 0.0315 | 0.5 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0191 | 1 | 1 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0097 | 0.0315 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0097 | 0.0315 | 0.5 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0191 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0097 | 0.0315 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0097 | 0.0315 | 0.0315 |
Onchocerca volvulus | 0.0191 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 52 % | Binding affinity for adenosine A2A receptor of rat striatal membrane by displacing [3H]-ZM-241,385 | ChEMBL. | 10999489 |
Ki (binding) | = 52.6 nM | Binding affinity for Adenosine A1 receptor of rat cortical membrane by displacing [3H]DPCPX | ChEMBL. | 10999489 |
Ki (binding) | = 340 nM | Binding affinity for Adenosine A3 receptor expressed in HEK 293 cells by displacing i[125I]-ABMECA | ChEMBL. | 10999489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.