Detailed information for compound 934932

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 3750.17 | Formula: C169H266N42O54
  • H donors: 49 H acceptors: 56 LogP: -11.83 Rotable bonds: 147
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CC(C)C)CC(C)C)CCC(=O)O)CCC(=O)N)CCC(=O)O)CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCNC(=O)Cn1nnc(c1)COC(=O)[C@@]12CCC(C[C@H]2C2=CC[C@H]3[C@@]([C@@]2(CC1)C)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)(C)C)CC(=O)N)CC(=O)N)Cc1ccc(cc1)O)CO)CC(C)C)Cc1cnc[nH]1)CO)CC(C)C)CCC(=O)O)CCC(=O)O)CO)CCC(=O)N)CC(=O)N)CCC(=O)N)CCC(=O)N)CCC(=O)O
  • InChi: 1S/C169H266N42O54/c1-21-84(11)134(160(261)193-102(39-49-133(236)237)144(245)189-101(38-48-132(234)235)147(248)203-113(75-212)157(258)192-97(34-44-122(174)221)145(246)200-111(69-125(177)224)151(252)190-96(33-43-121(173)220)141(242)185-94(31-41-119(171)218)139(240)187-98(35-45-129(228)229)142(243)184-93(25-23-24-59-170)138(239)199-110(68-124(176)223)152(253)191-99(36-46-130(230)231)143(244)186-95(32-42-120(172)219)140(241)188-100(37-47-131(232)233)146(247)195-104(62-81(5)6)148(249)194-103(137(179)238)61-80(3)4)206-154(255)105(63-82(7)8)196-158(259)114(76-213)204-149(250)108(66-88-72-180-79-182-88)202-161(262)135(85(12)22-2)207-155(256)106(64-83(9)10)197-159(260)115(77-214)205-162(263)136(86(13)215)208-156(257)107(65-87-26-28-90(216)29-27-87)198-153(254)112(70-126(178)225)201-150(251)109(67-123(175)222)183-127(226)52-60-181-128(227)74-211-73-89(209-210-211)78-265-163(264)169-57-55-164(14,15)71-92(169)91-30-40-117-166(18)53-51-118(217)165(16,17)116(166)50-54-168(117,20)167(91,19)56-58-169/h26-30,72-73,79-86,92-118,134-136,212-217H,21-25,31-71,74-78,170H2,1-20H3,(H2,171,218)(H2,172,219)(H2,173,220)(H2,174,221)(H2,175,222)(H2,176,223)(H2,177,224)(H2,178,225)(H2,179,238)(H,180,182)(H,181,227)(H,183,226)(H,184,243)(H,185,242)(H,186,244)(H,187,240)(H,188,241)(H,189,245)(H,190,252)(H,191,253)(H,192,258)(H,193,261)(H,194,249)(H,195,247)(H,196,259)(H,197,260)(H,198,254)(H,199,239)(H,200,246)(H,201,251)(H,202,262)(H,203,248)(H,204,250)(H,205,263)(H,206,255)(H,207,256)(H,208,257)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,236,237)/t84-,85-,86+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117+,118-,134-,135-,136-,166-,167+,168+,169-/m0/s1
  • InChiKey: JCQDYDZJXJNLBS-KOILWUGOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 GP41 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis hypothetical protein GP41   124 aa 110 aa 23.6 %
Neospora caninum Sec7 domain containing protein, related GP41   124 aa 124 aa 21.0 %
Leishmania braziliensis hypothetical protein, conserved GP41   124 aa 107 aa 29.0 %
Leishmania mexicana hypothetical protein, conserved GP41   124 aa 105 aa 29.5 %
Onchocerca volvulus GP41   124 aa 100 aa 22.0 %
Cryptosporidium parvum hypothetical protein GP41   124 aa 108 aa 18.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0071 0.0573 0.1927
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0044 0.0294 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0071 0.0573 0.2567
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Brugia malayi Sugar transporter family protein 0.0231 0.2234 1
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0177 0.0792
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0032 0.0177 0.2954
Echinococcus multilocularis solute carrier family 22 0.0032 0.0177 0.0792
Trichomonas vaginalis glucose transporter, putative 0.0072 0.0583 0.1973
Loa Loa (eye worm) hypothetical protein 0.0069 0.0559 0.25
Toxoplasma gondii protein kinase, putative 0.0652 0.6604 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0573 0.2567
Plasmodium falciparum calcium-dependent protein kinase 2 0.0071 0.0574 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0231 0.2234 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0071 0.0574 0.0617
Echinococcus multilocularis solute carrier family 22 0.0032 0.0177 0.0792
Echinococcus multilocularis solute carrier family 22 0.0032 0.0177 0.0792
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Loa Loa (eye worm) hypothetical protein 0.0052 0.0375 0.1677
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0071 0.0573 0.2567
Onchocerca volvulus 0.0032 0.0177 1
Trypanosoma brucei glucose transporter, putative 0.0072 0.0583 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0231 0.2234 1
Echinococcus granulosus solute carrier family 22 0.0032 0.0177 0.0792
Schistosoma mansoni protein kinase 0.0071 0.0573 0.2567
Trypanosoma brucei glucose transporter 1E 0.0072 0.0583 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0231 0.2234 1
Schistosoma mansoni glucose transport protein 0.0231 0.2234 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0583 0.8107
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Schistosoma mansoni sugar transporter 0.0032 0.0177 0.0792
Onchocerca volvulus 0.0032 0.0177 1
Echinococcus multilocularis General substrate transporter 0.0198 0.1898 0.8494
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0231 0.2234 1
Plasmodium falciparum protein kinase 7 0.0652 0.6604 0.6542
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0583 0.1973
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0583 0.1973
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Trypanosoma brucei glucose transporter, putative 0.0072 0.0583 0.8107
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0373 0.3708 0.3595
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0071 0.0573 0.2567
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0081 0.0678 1
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0094 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0573 0.2567
Schistosoma mansoni protein kinase 0.0071 0.0573 0.2567
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0231 0.2234 1
Echinococcus multilocularis calcium dependent protein kinase 0.0066 0.0528 0.2364
Onchocerca volvulus 0.0032 0.0177 1
Schistosoma mansoni glucose transport protein 0.0231 0.2234 1
Onchocerca volvulus 0.0032 0.0177 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0678 1
Echinococcus granulosus lysyl tRNA synthetase 0.0052 0.0375 0.1677
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0045 0.0309 0.0641
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0177 0.0792
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Echinococcus multilocularis solute carrier family 22 0.0032 0.0177 0.0792
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0678 1
Echinococcus granulosus solute carrier family 22 0.0032 0.0177 0.0792
Brugia malayi Cam kinase protein 1 0.0071 0.0573 0.2567
Plasmodium vivax proline--tRNA ligase, putative 0.0081 0.0678 0.051
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0071 0.0574 0.0617
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0071 0.0574 0.0404
Mycobacterium ulcerans integral membrane transport protein 0.0032 0.0177 0.2954
Entamoeba histolytica protein kinase, putative 0.0071 0.0573 1
Echinococcus granulosus solute carrier family 22 0.0032 0.0177 0.0792
Loa Loa (eye worm) sugar transporter 0.0231 0.2234 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0069 0.0559 1
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0246 0.1383
Trypanosoma brucei glucose transporter 2A 0.0072 0.0583 0.8107
Trypanosoma brucei glucose transporter, putative 0.0072 0.0583 0.8107
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0069 0.0559 0.25
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0583 0.1973
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0069 0.0559 0.25
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0052 0.0375 0.395
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0071 0.0573 0.2567
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0069 0.0559 0.25
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0071 0.0573 0.2567
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0375 0.1677
Plasmodium vivax lysine--tRNA ligase, putative 0.0052 0.0375 0.0201
Plasmodium falciparum proline--tRNA ligase 0.0081 0.0678 0.051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0071 0.0573 0.2567
Brugia malayi hypothetical protein 0.0032 0.0177 0.0792
Onchocerca volvulus 0.0032 0.0177 1
Schistosoma mansoni hypothetical protein 0.0231 0.2234 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0231 0.2234 1
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0583 0.8107
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0069 0.0559 0.1855
Trypanosoma brucei glucose transporter, putative 0.0072 0.0583 0.8107
Plasmodium falciparum calcium-dependent protein kinase 3 0.0071 0.0574 0.0404
Trypanosoma cruzi hexose transporter 0.0072 0.0583 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0583 0.1973
Echinococcus multilocularis synaptic vesicle 2 protein 0.0032 0.0177 0.0792
Plasmodium falciparum lysine--tRNA ligase 0.0052 0.0375 0.0201
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0231 0.2234 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0373 0.3708 0.3595
Schistosoma mansoni glucose transport protein 0.0231 0.2234 1
Brugia malayi hypothetical protein 0.0032 0.0177 0.0792
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0071 0.0573 0.2567
Schistosoma mansoni sugar transporter 0.0032 0.0177 0.0792
Echinococcus granulosus calcium dependent protein kinase 0.0066 0.0528 0.2364
Onchocerca volvulus 0.0032 0.0177 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0052 0.0375 0.1677
Schistosoma mansoni sugar transporter 0.0032 0.0177 0.0792
Schistosoma mansoni glucose transporter 0.0032 0.0177 0.0792
Brugia malayi Sugar transporter family protein 0.0032 0.0177 0.0792
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0231 0.2234 1
Onchocerca volvulus 0.0032 0.0177 1
Onchocerca volvulus 0.0032 0.0177 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0071 0.0574 0.0404
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0583 0.8107
Schistosoma mansoni sugar transporter 0.0032 0.0177 0.0792
Chlamydia trachomatis lysine--tRNA ligase 0.0052 0.0375 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0071 0.0573 0.2567
Leishmania major glucose transporter, lmgt3 0.0072 0.0583 0.8107
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0071 0.0573 0.7919
Trypanosoma brucei glucose transporter, putative 0.0072 0.0583 0.8107
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0071 0.0574 0.0404
Leishmania major glucose transporter, lmgt2 0.0072 0.0583 0.8107
Plasmodium falciparum hexose transporter 0.0231 0.2234 0.2094
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0373 0.3708 0.5495
Trichomonas vaginalis glucose transporter, putative 0.0072 0.0583 0.1973
Brugia malayi major facilitator superfamily protein 0.0032 0.0177 0.0792
Onchocerca volvulus 0.0032 0.0177 1
Leishmania major glucose transporter, lmgt1 0.0072 0.0583 0.8107
Onchocerca volvulus 0.0032 0.0177 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0032 0.0177 0.2954
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0044 0.0294 1
Brugia malayi Sugar transporter family protein 0.0032 0.0177 0.0792
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.0135 0.0605
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0052 0.0375 0.3046
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0069 0.0559 0.25
Toxoplasma gondii lysine-tRNA ligase 0.0052 0.0375 0.0308
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0052 0.0375 0.0961
Toxoplasma gondii facilitative glucose transporter GT1 0.0231 0.2234 0.3201
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0583 0.1973
Trypanosoma brucei glucose transporter, putative 0.0072 0.0583 0.8107
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0375 1
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0583 0.8107
Loa Loa (eye worm) sugar transporter 0.0032 0.0177 0.0792
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Echinococcus granulosus General substrate transporter 0.0198 0.1898 0.8494
Trypanosoma brucei glucose transporter, putative 0.0072 0.0583 0.8107
Entamoeba histolytica protein kinase, putative 0.0071 0.0573 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Trichomonas vaginalis conserved hypothetical protein 0.0231 0.2234 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0081 0.0678 1
Brugia malayi major facilitator superfamily protein 0.0032 0.0177 0.0792
Plasmodium vivax CDK-related protein kinase 6, putative 0.098 1 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0375 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Giardia lamblia Lysyl-tRNA synthetase 0.0052 0.0375 0.5182
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0071 0.0573 0.2567
Onchocerca volvulus 0.0032 0.0177 1
Onchocerca volvulus 0.0032 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0069 0.0559 0.25
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0177 0.0792
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0177 0.0792
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0032 0.0177 0.5
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0071 0.0573 0.2567
Plasmodium falciparum calcium-dependent protein kinase 5 0.0071 0.0574 0.0404
Plasmodium vivax hexose transporter 0.0231 0.2234 0.2094
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0071 0.0574 0.0617
Brugia malayi lysyl-tRNA synthetase 0.0052 0.0375 0.1677
Echinococcus granulosus solute carrier family 22 0.0032 0.0177 0.0792
Trypanosoma brucei glucose transporter, putative 0.0072 0.0583 0.8107
Leishmania major lysyl-tRNA synthetase, putative 0.0052 0.0375 0.395
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Onchocerca volvulus Putative transporter 0.0032 0.0177 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0071 0.0573 0.2567
Onchocerca volvulus 0.0032 0.0177 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0032 0.0177 0.0792
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0583 0.8107
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0069 0.0559 0.9253
Leishmania major glucose transporter/membrane transporter D2, putative 0.0072 0.0583 0.8107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0583 0.8107
Onchocerca volvulus 0.0032 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0032 0.0177 0.0792
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0032 0.0177 0.0792
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0375 0.1677
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0081 0.0678 0.0779
Onchocerca volvulus 0.0032 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Echinococcus granulosus synaptic vesicle 2 protein 0.0032 0.0177 0.0792
Plasmodium falciparum calcium-dependent protein kinase 1 0.0071 0.0574 0.0404
Giardia lamblia Prolyl-tRNA synthetase 0.0069 0.0559 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0678 1
Onchocerca volvulus 0.0032 0.0177 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0071 0.0574 0.0404
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0792
Loa Loa (eye worm) hypothetical protein 0.0056 0.0424 0.1897
Plasmodium falciparum calcium-dependent protein kinase 4 0.0071 0.0574 0.0404
Leishmania major protein kinase, putative 0.0071 0.0573 0.7919
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0375 0.395
Brugia malayi hypothetical protein 0.0032 0.0177 0.0792
Mycobacterium ulcerans sugar transporter 0.0032 0.0177 0.2954
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0069 0.0559 0.25
Schistosoma mansoni protein kinase 0.0071 0.0573 0.2567
Loa Loa (eye worm) hypothetical protein 0.0069 0.0559 0.25
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0177 0.0792

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 25 nM Cytotoxicity against human MT2 cells after 4 days by XTT assay ChEMBL. 25156906
EC50 (binding) = 176 nM Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells after 6 to 8 hrs by luciferase assay ChEMBL. 25156906

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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