TDR Targets

Basic information

Technical information

TDR Targets ID: 935589
Name: N-(furan-2-ylmethyl)-5-phenyl-2H-pyrazole-3-c arboxamide
MW: 267.283 | Formula: C15H13N3O2
H donors: 2 H acceptors: 2 LogP: 2.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1n[nH]c(c1)c1ccccc1)NCc1ccco1
InChi: 1S/C15H13N3O2/c19-15(16-10-12-7-4-8-20-12)14-9-13(17-18-14)11-5-2-1-3-6-11/h1-9H,10H2,(H,16,19)(H,17,18)
InChiKey: GKUNTQALYUVTFI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-furylmethyl)-5-phenyl-2H-pyrazole-3-carboxamide
ZINC07752640

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 8	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Schistosoma japonicum	IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing	Get druggable targets OG5_129677	All targets in OG5_129677
Schistosoma japonicum	ko:K04440 c-Jun N-terminal kinase, putative	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus granulosus	c-Jun N-terminal kinases	Get druggable targets OG5_129677	All targets in OG5_129677
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus multilocularis	c Jun NH2 terminal kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Brugia malayi	Stress-activated protein kinase jnk-1	Get druggable targets OG5_129677	All targets in OG5_129677

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1068	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1068	1	1
Toxoplasma gondii	cathepsin CPL	0.0567	0.3658	1
Loa Loa (eye worm)	cysteine protease	0.0567	0.3658	0.3658
Echinococcus granulosus	cathepsin b	0.1068	1	1
Echinococcus granulosus	cathepsin l1	0.0567	0.3658	0.3658
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0389	0.1404	0.3182
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0567	0.3658	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0567	0.3658	0.3658
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0567	0.3658	0.3658
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0306	0.0353	0.0353
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1068	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0567	0.3658	0.3658
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Echinococcus multilocularis	cathepsin b	0.1068	1	1
Leishmania major	cathepsin L-like protease	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0419	0.178	0.4318
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0419	0.178	0.1479
Trypanosoma cruzi	cysteine peptidase, putative	0.0567	0.3658	0.3426
Leishmania major	cysteine peptidase A (CPA)	0.0567	0.3658	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0419	0.178	0.4318
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Onchocerca volvulus		0.0567	0.3658	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Echinococcus multilocularis	cysteine protease	0.0567	0.3658	0.3658
Trypanosoma cruzi	cysteine peptidase, putative	0.0567	0.3658	0.3426
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Leishmania major	cathepsin L-like protease	0.0567	0.3658	1
Loa Loa (eye worm)	cathepsin B	0.0419	0.178	0.178
Giardia lamblia	Cathepsin B precursor	0.0419	0.178	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0389	0.1404	0.109
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0567	0.3658	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0567	0.3658	0.3426
Echinococcus multilocularis	cathepsin L	0.0306	0.0353	0.0353
Loa Loa (eye worm)	ctsf protein	0.0567	0.3658	0.3658
Loa Loa (eye worm)	hypothetical protein	0.0389	0.1404	0.1404
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Echinococcus multilocularis	cysteine protease	0.0567	0.3658	0.3658
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0567	0.3658	0.3658
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1068	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Loa Loa (eye worm)	hypothetical protein	0.0567	0.3658	0.3658
Plasmodium vivax	vivapain-2	0.0567	0.3658	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0567	0.3658	0.3658
Brugia malayi	Cathepsin L-like precursor	0.0567	0.3658	0.3658
Leishmania major	cathepsin L-like protease	0.0567	0.3658	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0389	0.1404	0.1404
Entamoeba histolytica	cysteine proteinase, putative	0.0567	0.3658	1
Brugia malayi	Papain family cysteine protease containing protein	0.0306	0.0353	0.0353
Onchocerca volvulus	Cathepsin L homolog	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0389	0.1404	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0567	0.3658	0.3658
Onchocerca volvulus		0.0567	0.3658	1
Brugia malayi	Papain family cysteine protease containing protein	0.0306	0.0353	0.0353
Echinococcus granulosus	cathepsin b	0.1068	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1068	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0306	0.0353	0.0353
Onchocerca volvulus		0.0567	0.3658	1
Entamoeba histolytica	cysteine protease, putative	0.0567	0.3658	1
Brugia malayi	Papain family cysteine protease containing protein	0.0567	0.3658	0.3658
Onchocerca volvulus		0.0567	0.3658	1
Brugia malayi	Cathepsin L-like precursor	0.0389	0.1404	0.1404
Giardia lamblia	Cathepsin B precursor	0.0419	0.178	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Entamoeba histolytica	cysteine proteinase, putative	0.0389	0.1404	0.3182
Echinococcus multilocularis	cathepsin b	0.1068	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Leishmania major	cathepsin L-like protease	0.0567	0.3658	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0567	0.3658	0.3658
Loa Loa (eye worm)	hypothetical protein	0.1068	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0419	0.178	0.178
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0567	0.3658	0.3658
Brugia malayi	Cathepsin L-like precursor	0.0567	0.3658	0.3658
Onchocerca volvulus	Cathepsin F homolog	0.0567	0.3658	1
Loa Loa (eye worm)	fibroinase	0.0567	0.3658	0.3658
Echinococcus granulosus	cysteine protease	0.0306	0.0353	0.0353
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Brugia malayi	Cathepsin L-like precursor	0.0389	0.1404	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Leishmania major	cathepsin L-like protease	0.0567	0.3658	1
Leishmania major	cathepsin L-like protease	0.0567	0.3658	1
Brugia malayi	Cathepsin L-like precursor	0.0567	0.3658	0.3658
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0306	0.0353	0.0353
Schistosoma mansoni	cathepsin F (C01 family)	0.0567	0.3658	0.3658
Onchocerca volvulus	Cathepsin L homolog	0.0567	0.3658	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0567	0.3658	0.3426
Brugia malayi	Cathepsin L-like precursor	0.0567	0.3658	0.3658
Onchocerca volvulus		0.0567	0.3658	1
Onchocerca volvulus		0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Brugia malayi	Cathepsin L-like precursor	0.0567	0.3658	0.3658
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Entamoeba histolytica	cysteine proteinase, putative	0.0567	0.3658	1
Leishmania major	cathepsin L-like protease	0.0567	0.3658	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0389	0.1404	0.1404
Plasmodium vivax	vivapain-2	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0567	0.3658	1
Loa Loa (eye worm)	hypothetical protein	0.0389	0.1404	0.1404
Loa Loa (eye worm)	hypothetical protein	0.0389	0.1404	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0567	0.3658	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Giardia lamblia	Cathepsin B precursor	0.0419	0.178	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Leishmania major	cathepsin L-like protease	0.0567	0.3658	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0567	0.3658	0.3426
Onchocerca volvulus		0.0567	0.3658	1
Echinococcus granulosus	cathepsin l1	0.0389	0.1404	0.1404
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0567	0.3658	0.3658
Echinococcus granulosus	cathepsin L	0.0306	0.0353	0.0353
Echinococcus granulosus	cathepsin L cysteine protease	0.0306	0.0353	0.0353
Brugia malayi	cathepsin L-like precursor	0.0389	0.1404	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0567	0.3658	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0567	0.3658	1
Brugia malayi	Cathepsin L-like precursor	0.0567	0.3658	0.3658

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.8 uM	Inhibition of FLAG-tagged JNK-1 (unknown origin) transfected in African green monkey COS cells by SDS-PAGE analysis	ChEMBL.	25261929

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3342921

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 935589