Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | 3-oxoacyl-[acyl-carrier-protein] synthase III | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 3-oxoacyl-[acyl-carrier-protein] synthase III | 317 aa | 265 aa | 26.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0117 | 0.2206 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0018 | 0.0246 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0871 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0871 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0018 | 0.0246 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0019 | 0.0271 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 0.7449 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0383 | 0.7449 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0021 | 0.0306 | 0.0306 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0021 | 0.0306 | 0.0306 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.7449 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 0.7449 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 0.7449 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 0.7449 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0221 | 0.8141 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0871 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0117 | 0.2206 | 0.2206 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0019 | 0.0271 | 0.1229 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0019 | 0.0271 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0871 | 0.5 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0117 | 0.2206 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0871 | 0.5 |
Toxoplasma gondii | MAPEG family protein | 0.0117 | 0.2206 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 0.7449 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.7449 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0019 | 0.0271 | 0.1229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.