TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 432.555 | Formula: C27H32N2O3
H donors: 1 H acceptors: 0 LogP: 5.37 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1ccc(cc1)NCCCN1CCc2c(C1)cc(c(c2)OC)OC
InChi: 1S/C27H32N2O3/c1-30-25-11-7-21(8-12-25)20-5-9-24(10-6-20)28-14-4-15-29-16-13-22-17-26(31-2)27(32-3)18-23(22)19-29/h5-12,17-18,28H,4,13-16,19H2,1-3H3
InChiKey: UJKJUHUUFKTEDM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glyco protein 6, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	ATP-binding cassette, sub-family B (MDR/TAP), member 4, related	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium falciparum	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Bile salt export pump, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ATP-binding cassette sub-family B member 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	taga, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium vivax	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium yoelii	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	smdr2	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium hominis	ATP-binding cassette protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium knowlesi	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette transporter	Get druggable targets OG5_126596	All targets in OG5_126596
Onchocerca volvulus		Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-5	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium berghei	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	larval opioid receptor	0.0065	0.8879	0.8831
Brugia malayi	ORL1-like opioid receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0044	0.5706	0.5521
Schistosoma mansoni	histamine h1 receptor	0.0065	0.8879	0.8863
Onchocerca volvulus		0.0065	0.8879	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0065	0.8879	0.8831
Brugia malayi	ABC transporter family protein	0.0013	0.1036	0.0649
Onchocerca volvulus		0.0065	0.8879	1
Trichomonas vaginalis	proliferating cell nuclear antigen, putative	0.0072	1	1
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0065	0.8879	0.8831
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0065	0.8879	0.8831
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0065	0.8879	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	fmrfamide receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	fmrfamide receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.1036	0.0649
Echinococcus multilocularis	G protein coupled receptor 139	0.0065	0.8879	0.8831
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1036	0.0649
Brugia malayi	follicle stimulating hormone receptor	0.0065	0.8879	0.8831
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.1036	0.0649
Echinococcus granulosus	serotonin receptor	0.0065	0.8879	0.8831
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1036	0.0649
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1036	0.0649
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.1019	0.0632
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1036	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	G-protein coupled receptor	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Trypanosoma cruzi	proliferative cell nuclear antigen (PCNA), putative	0.0072	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0065	0.8879	0.8831
Echinococcus granulosus	proliferating cell nuclear antigen	0.0072	1	1
Onchocerca volvulus		0.0065	0.8879	1
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0013	0.1015	0.0627
Echinococcus granulosus	neuropeptide FF receptor 2	0.0065	0.8879	0.8831
Echinococcus granulosus	7tm_1 domain containing protein	0.0065	0.8879	0.8831
Echinococcus granulosus	biogenic amine 5HT receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	proliferating cell nuclear antigen	0.0072	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.8879	0.8831
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0065	0.8879	0.8863
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0013	0.1036	0.5
Onchocerca volvulus		0.0065	0.8879	1
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.1036	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0065	0.8879	0.8831
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.1036	0.0649
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Plasmodium falciparum	proliferating cell nuclear antigen 2	0.0038	0.4934	0.4348
Echinococcus granulosus	g protein coupled receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	melatonin receptor type 1A	0.0065	0.8879	0.8831
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0065	0.8879	0.8863
Brugia malayi	putative neuropeptide receptor NPR1	0.0065	0.8879	0.8831
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.8879	0.8831
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.1036	0.0649
Schistosoma mansoni	proliferating cell nuclear antigen	0.0072	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.1019	0.0632
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1036	0.0649
Brugia malayi	Serotonin receptor	0.0065	0.8879	0.8831
Trichomonas vaginalis	proliferating cell nuclear antigen, putative	0.0072	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0013	0.1015	0.0627
Loa Loa (eye worm)	G-protein coupled receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Brugia malayi	neuropeptide F receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	hypothetical protein	0.0065	0.8879	0.8863
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1036	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4834	0.4612
Schistosoma mansoni	opsin-like receptor	0.0065	0.8879	0.8863
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0065	0.8879	0.8831
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1036	0.0649
Schistosoma mansoni	neuropeptide f receptor 76f	0.0065	0.8879	0.8863
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1036	0.0649
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0041	0.5271	0.5068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1036	0.0649
Schistosoma mansoni	voltage-gated potassium channel	0.0048	0.6312	0.6256
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	biogenic amine receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	G protein coupled receptor 139	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Echinococcus multilocularis	serotonin receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	orexin receptor type 2	0.0065	0.8879	0.8831
Plasmodium falciparum	proliferating cell nuclear antigen 1	0.0072	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0413	0.0269
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1036	0.0649
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.1036	0.0649
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0065	0.8879	0.8863
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1036	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1036	0.0649
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1036	0.0649
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0065	0.8879	0.8831
Echinococcus granulosus	allatostatin A receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	multidrug resistance protein	0.0013	0.1036	0.0901
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	amine GPCR	0.0065	0.8879	0.8863
Trichomonas vaginalis	abcb9, putative	0.0013	0.1036	0.0649
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0065	0.8879	1
Echinococcus multilocularis	sex peptide receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0013	0.1036	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	voltage-gated potassium channel	0.0048	0.6312	0.6256
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0065	0.8879	0.8831
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1036	0.0649
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Brugia malayi	G-protein coupled receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	serotonin receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	voltage-gated potassium channel	0.0009	0.0413	0.0269
Echinococcus multilocularis	somatostatin receptor	0.0065	0.8879	0.8831
Brugia malayi	Serotonin receptor	0.0065	0.8879	0.8831
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0013	0.1036	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0065	0.8879	0.8863
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.8879	0.8863
Echinococcus multilocularis	neuropeptides capa receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1036	0.0649
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0044	0.5706	0.5521
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1015	0.0627
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Onchocerca volvulus		0.0065	0.8879	1
Echinococcus granulosus	neuropeptide receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0065	0.8879	0.8863
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.1036	0.0649
Echinococcus multilocularis	neuropeptide s receptor	0.0065	0.8879	0.8831
Echinococcus granulosus	g protein coupled receptor	0.0065	0.8879	0.8831
Toxoplasma gondii	proliferating cell nuclear antigen PCNA1	0.0072	1	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Echinococcus multilocularis	neuropeptide Y receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	neuropeptide F-like receptor	0.0065	0.8879	0.8863
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1036	0.0649
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	amine GPCR	0.0065	0.8879	0.8863
Entamoeba histolytica	proliferating cell nuclear antigen, putative	0.0072	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	opsin-like receptor	0.0065	0.8879	0.8863
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.8879	0.8831
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0065	0.8879	0.8831
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1036	0.0649
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.1019	0.0632
Brugia malayi	neuropeptide F receptor	0.0065	0.8879	0.8831
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.8879	0.8831
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0065	0.8879	0.8831
Schistosoma mansoni	amine GPCR	0.0065	0.8879	0.8863
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.1036	0.0649
Schistosoma mansoni	neuropeptide receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0065	0.8879	0.8831
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0065	0.8879	0.8831
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0065	0.8879	0.8863
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus granulosus	neuropeptides capa receptor	0.0065	0.8879	0.8831
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0065	0.8879	0.8831
Schistosoma mansoni	multidrug resistance protein	0.0013	0.1036	0.0901
Echinococcus granulosus	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0413	0.0269
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0065	0.8879	0.8831
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0065	0.8879	0.8863
Onchocerca volvulus		0.0065	0.8879	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1036	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.1036	0.0649
Echinococcus multilocularis	multidrug resistance protein 1	0.0009	0.0453	0.0042
Brugia malayi	Dopamine receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1036	0.0649
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	growth hormone secretagogue receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0065	0.8879	0.8831
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.1036	0.0649
Echinococcus granulosus	g-protein coupled receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.1019	0.0632
Echinococcus multilocularis	g-protein coupled receptor	0.0065	0.8879	0.8831
Echinococcus granulosus	neuropeptide Y receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Brugia malayi	RE15519p	0.0065	0.8879	0.8831
Trypanosoma brucei	proliferative cell nuclear antigen (PCNA), putative	0.0072	1	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1036	0.0649
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.1019	0.0884
Toxoplasma gondii	proliferating cell nuclear antigen PCNA2	0.0038	0.4934	0.4348
Schistosoma mansoni	hypothetical protein	0.0065	0.8879	0.8863
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Brugia malayi	G protein-coupled receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Echinococcus granulosus	orexin receptor type 2	0.0065	0.8879	0.8831
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.1036	0.0649
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.1036	0.0649
Schistosoma mansoni	hypothetical protein	0.0065	0.8879	0.8863
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	7TM GPCR rhodopsin	0.0065	0.8879	0.8831
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1036	0.0649
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.1036	0.0649
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Trichomonas vaginalis	abcb9, putative	0.0013	0.1036	0.0649
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Schistosoma mansoni	adenoreceptor	0.0065	0.8879	0.8863
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0413	0.0269
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Echinococcus multilocularis	allatostatin A receptor	0.0065	0.8879	0.8831
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0041	0.5271	0.5068
Brugia malayi	GnHR receptor homolog	0.0065	0.8879	0.8831
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.1036	0.0649
Echinococcus granulosus	g protein coupled receptor	0.0065	0.8879	0.8831
Brugia malayi	G protein-coupled receptor F59B2.13	0.0065	0.8879	0.8831
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1036	0.0649
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.1036	0.0649
Onchocerca volvulus		0.0065	0.8879	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	hypothetical protein	0.0065	0.8879	0.8863
Trichomonas vaginalis	taga, putative	0.0013	0.1036	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.8879	0.8831
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	neuropeptide receptor A26	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus granulosus	neuropeptide s receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	neuropeptide receptor	0.0065	0.8879	0.8863
Brugia malayi	sulfakinin receptor protein	0.0065	0.8879	0.8831
Echinococcus granulosus	multidrug resistance protein 1	0.0009	0.0453	0.0042
Schistosoma mansoni	opsin-like receptor	0.0065	0.8879	0.8863
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.8879	0.8831
Onchocerca volvulus		0.0065	0.8879	1
Brugia malayi	Melatonin receptor type 1A	0.0065	0.8879	0.8831
Brugia malayi	putative neuropeptide receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	multidrug resistance protein 3	0.0013	0.1036	0.0649
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0065	0.8879	0.8831
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	biogenic amine receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	multidrug resistance protein 1	0.0009	0.0453	0.0042
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0065	0.8879	0.8863
Leishmania major	proliferative cell nuclear antigen (PCNA), putative	0.0072	1	1
Schistosoma mansoni	smdr2	0.0013	0.1036	0.0901
Loa Loa (eye worm)	neuropeptide F receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	neuropeptide F receptor	0.0065	0.8879	0.8831
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1036	0.0649
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0413	0.0269
Trypanosoma cruzi	proliferative cell nuclear antigen (PCNA), putative	0.0072	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus granulosus	dro:myosuppressin receptor	0.0065	0.8879	0.8831
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0065	0.8879	0.8831
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0065	0.8879	0.8831
Schistosoma mansoni	neuropeptide receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	neuropeptide receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.8879	0.8863
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Brugia malayi	Dopamine receptor protein 2	0.0065	0.8879	0.8831
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.1019	0.0884
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.1019	0.0632
Onchocerca volvulus		0.0065	0.8879	1
Brugia malayi	Dopamine receptor protein 1	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	TYRA-2 protein	0.0065	0.8879	0.8831
Brugia malayi	multidrug resistance protein 3	0.0013	0.1036	0.0649
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	amine GPCR	0.0065	0.8879	0.8863
Brugia malayi	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0065	0.8879	0.8863
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0065	0.8879	0.8863
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.1036	0.0649
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0044	0.5706	0.5521
Schistosoma mansoni	neuropeptide receptor	0.0065	0.8879	0.8863
Plasmodium vivax	proliferating cell nuclear antigen, putative	0.0038	0.4934	0.4348
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Giardia lamblia	PcnA	0.0072	1	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.1036	0.0649
Loa Loa (eye worm)	proliferating cell nuclear antigen	0.0072	1	1
Echinococcus granulosus	sex peptide receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0044	0.5706	0.5521
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0065	0.8879	0.8831
Echinococcus granulosus	fmrfamide receptor	0.0065	0.8879	0.8831
Brugia malayi	AKH receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	multidrug resistance protein	0.0013	0.1036	0.0901
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0009	0.0453	0.0042
Echinococcus multilocularis	neuropeptide Y receptor	0.0065	0.8879	0.8831
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.1036	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0065	0.8879	0.8863
Echinococcus multilocularis	dro:myosuppressin receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0065	0.8879	0.8831
Echinococcus multilocularis	neuropeptide receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0065	0.8879	0.8831
Echinococcus granulosus	somatostatin receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0413	0.0269
Echinococcus granulosus	neuropeptides capa receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	myosin xvIII	0.0065	0.8879	0.8863
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Schistosoma mansoni	biogenic amine receptor	0.0065	0.8879	0.8863
Echinococcus multilocularis	neuropeptide receptor	0.0065	0.8879	0.8831
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0065	0.8879	0.8863
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.8879	0.8831
Trichomonas vaginalis	abcb9, putative	0.0013	0.1036	0.0649
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0065	0.8879	0.8831
Echinococcus granulosus	neuropeptide Y receptor	0.0065	0.8879	0.8831
Echinococcus multilocularis	proliferating cell nuclear antigen	0.0072	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.8879	0.8863
Plasmodium vivax	proliferating cell nuclear antigen, putative	0.0072	1	1
Schistosoma mansoni	amine GPCR	0.0065	0.8879	0.8863
Brugia malayi	G-protein coupled receptor	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0065	0.8879	0.8831
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1019	0.0632
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0065	0.8879	0.8831
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.1036	0.0649

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)		Inhibition of MRP1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay	ChEMBL.	25379609
EC50 (binding)	= 1.8 uM	Inhibition of MDR1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay	ChEMBL.	25379609
Inhibition (binding)		Inhibition of BCRP (unknown origin) over-expressed in MDCK cells assessed as Hoechst 33342 accumulation incubated for 30 mins prior to Hoechst 33342 addition measured after 30 mins by fluorescence assay	ChEMBL.	25379609

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3352984

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 945604