Detailed information for compound 945604

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.555 | Formula: C27H32N2O3
  • H donors: 1 H acceptors: 0 LogP: 5.37 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1ccc(cc1)NCCCN1CCc2c(C1)cc(c(c2)OC)OC
  • InChi: 1S/C27H32N2O3/c1-30-25-11-7-21(8-12-25)20-5-9-24(10-6-20)28-14-4-15-29-16-13-22-17-26(31-2)27(32-3)18-23(22)19-29/h5-12,17-18,28H,4,13-16,19H2,1-3H3
  • InChiKey: UJKJUHUUFKTEDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.8879 0.8831
Echinococcus granulosus neuropeptide s receptor 0.0065 0.8879 0.8831
Schistosoma mansoni growth hormone secretagogue receptor 0.0065 0.8879 0.8863
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.1036 0.0649
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0013 0.1015 0.0627
Schistosoma mansoni opsin-like receptor 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni neuropeptide receptor 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0065 0.8879 0.8831
Brugia malayi larval opioid receptor 0.0065 0.8879 0.8831
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.8879 0.8831
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.8879 0.8831
Echinococcus granulosus proliferating cell nuclear antigen 0.0072 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.8879 0.8831
Echinococcus granulosus neuropeptide receptor 0.0065 0.8879 0.8831
Trichomonas vaginalis ABC transporter, putative 0.0013 0.1036 0.0649
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0065 0.8879 0.8863
Loa Loa (eye worm) proliferating cell nuclear antigen 0.0072 1 1
Schistosoma mansoni proliferating cell nuclear antigen 0.0072 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.1015 0.0627
Echinococcus granulosus allatostatin A receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni smdr2 0.0013 0.1036 0.0901
Schistosoma mansoni histamine h1 receptor 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.1036 0.0649
Echinococcus granulosus G protein coupled receptor 139 0.0065 0.8879 0.8831
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.1036 0.0649
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.8879 0.8831
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.1036 0.0649
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0065 0.8879 0.8863
Brugia malayi Tachykinin-like peptides receptor 99D 0.0065 0.8879 0.8831
Toxoplasma gondii proliferating cell nuclear antigen PCNA2 0.0038 0.4934 0.4348
Brugia malayi GnHR receptor homolog 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.1019 0.0632
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.1036 0.0649
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.1036 0.0649
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.1036 0.0649
Onchocerca volvulus 0.0065 0.8879 1
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.8879 0.8863
Brugia malayi AKH receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis allatostatin A receptor 0.0065 0.8879 0.8831
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.1036 0.0649
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.8879 0.8831
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.1036 0.0649
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.1036 0.0649
Echinococcus granulosus 7TM GPCR rhodopsin 0.0065 0.8879 0.8831
Echinococcus multilocularis serotonin receptor 0.0065 0.8879 0.8831
Schistosoma mansoni biogenic amine receptor 0.0065 0.8879 0.8863
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0065 0.8879 0.8831
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.1036 0.0649
Onchocerca volvulus 0.0065 0.8879 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.1015 0.0627
Echinococcus multilocularis fmrfamide receptor 0.0065 0.8879 0.8831
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0065 0.8879 0.8831
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.8879 0.8831
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Echinococcus multilocularis G protein coupled receptor 139 0.0065 0.8879 0.8831
Onchocerca volvulus 0.0065 0.8879 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0065 0.8879 0.8831
Schistosoma mansoni biogenic amine receptor 0.0065 0.8879 0.8863
Toxoplasma gondii proliferating cell nuclear antigen PCNA1 0.0072 1 1
Onchocerca volvulus 0.0065 0.8879 1
Brugia malayi sulfakinin receptor protein 0.0065 0.8879 0.8831
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Onchocerca volvulus 0.0065 0.8879 1
Brugia malayi follicle stimulating hormone receptor 0.0065 0.8879 0.8831
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Echinococcus granulosus fmrfamide receptor 0.0065 0.8879 0.8831
Leishmania major proliferative cell nuclear antigen (PCNA), putative 0.0072 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.1036 0.0649
Echinococcus granulosus voltage gated potassium channel 0.0013 0.1019 0.0632
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni amine GPCR 0.0065 0.8879 0.8863
Loa Loa (eye worm) melatonin receptor type 1A 0.0065 0.8879 0.8831
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.1036 0.0649
Plasmodium falciparum proliferating cell nuclear antigen 1 0.0072 1 1
Schistosoma mansoni hypothetical protein 0.0065 0.8879 0.8863
Echinococcus granulosus sex peptide receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis proliferating cell nuclear antigen 0.0072 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.5706 0.5521
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.8879 0.8863
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0065 0.8879 0.8863
Schistosoma mansoni amine GPCR 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.8879 0.8863
Trichomonas vaginalis ABC transporter, putative 0.0013 0.1036 0.0649
Echinococcus granulosus hypothetical protein 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni neuropeptide receptor 0.0065 0.8879 0.8863
Echinococcus granulosus g-protein coupled receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.1019 0.0632
Echinococcus granulosus orexin receptor type 2 0.0065 0.8879 0.8831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0065 0.8879 0.8863
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.1036 0.0649
Echinococcus multilocularis neuropeptide receptor 0.0065 0.8879 0.8831
Brugia malayi neuropeptide F receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni myosin xvIII 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Onchocerca volvulus 0.0065 0.8879 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Trypanosoma brucei proliferative cell nuclear antigen (PCNA), putative 0.0072 1 0.5
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.1036 0.0649
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.1036 0.0649
Schistosoma mansoni adenoreceptor 0.0065 0.8879 0.8863
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.8879 0.8863
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0413 0.0269
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.1019 0.0632
Schistosoma mansoni opsin-like receptor 0.0065 0.8879 0.8863
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.1036 0.0649
Echinococcus granulosus 7tm_1 domain containing protein 0.0065 0.8879 0.8831
Echinococcus multilocularis g protein coupled receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni proliferating cell nuclear antigen 0.0072 1 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.1036 0.0649
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Brugia malayi Serotonin receptor 0.0065 0.8879 0.8831
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.8879 0.8863
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.8879 0.8831
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0072 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Schistosoma mansoni amine GPCR 0.0065 0.8879 0.8863
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0413 0.0269
Brugia malayi Dopamine receptor 0.0065 0.8879 0.8831
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0065 0.8879 0.8831
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0065 0.8879 0.8831
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0065 0.8879 1
Echinococcus multilocularis g-protein coupled receptor 0.0065 0.8879 0.8831
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0065 0.8879 0.8831
Schistosoma mansoni biogenic amine receptor 0.0065 0.8879 0.8863
Brugia malayi G protein-coupled receptor 0.0065 0.8879 0.8831
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0038 0.4834 0.4612
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.1036 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0065 0.8879 0.8863
Echinococcus granulosus peptide allatostatin:somatostatin 0.0065 0.8879 0.8831
Schistosoma mansoni amine GPCR 0.0065 0.8879 0.8863
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Onchocerca volvulus 0.0065 0.8879 1
Onchocerca volvulus 0.0065 0.8879 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0413 0.0269
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.1036 0.0649
Schistosoma mansoni alpha-1 adrenergic receptor 0.0065 0.8879 0.8863
Schistosoma mansoni neuropeptide receptor 0.0065 0.8879 0.8863
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.8879 0.8831
Schistosoma mansoni multidrug resistance protein 0.0013 0.1036 0.0901
Echinococcus granulosus neuropeptide receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni multidrug resistance protein 0.0013 0.1036 0.0901
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Echinococcus granulosus g protein coupled receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Brugia malayi neuropeptide F receptor 0.0065 0.8879 0.8831
Echinococcus granulosus alpha 1A adrenergic receptor 0.0065 0.8879 0.8831
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.1036 0.0649
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0065 0.8879 0.8831
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0065 0.8879 0.8831
Brugia malayi G protein-coupled receptor F59B2.13 0.0065 0.8879 0.8831
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.1036 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.6312 0.6256
Trichomonas vaginalis ABC transporter, putative 0.0013 0.1036 0.0649
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.0453 0.0042
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0072 1 1
Brugia malayi Melatonin receptor type 1A 0.0065 0.8879 0.8831
Echinococcus multilocularis serotonin receptor 0.0065 0.8879 0.8831
Brugia malayi Dopamine receptor protein 1 0.0065 0.8879 0.8831
Brugia malayi ORL1-like opioid receptor 0.0065 0.8879 0.8831
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.1036 0.0649
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.1036 0.0649
Onchocerca volvulus 0.0065 0.8879 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni neuropeptide f receptor 76f 0.0065 0.8879 0.8863
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0065 0.8879 0.8831
Brugia malayi putative neuropeptide receptor 0.0065 0.8879 0.8831
Echinococcus granulosus serotonin receptor 0.0065 0.8879 0.8831
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0072 1 0.5
Entamoeba histolytica proliferating cell nuclear antigen, putative 0.0072 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.8879 0.8831
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.1036 0.0649
Brugia malayi G-protein coupled receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis neuropeptide s receptor 0.0065 0.8879 0.8831
Brugia malayi G-protein coupled receptor 0.0065 0.8879 0.8831
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.8879 0.8863
Brugia malayi putative neuropeptide receptor NPR1 0.0065 0.8879 0.8831
Onchocerca volvulus 0.0065 0.8879 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0065 0.8879 1
Schistosoma mansoni hypothetical protein 0.0065 0.8879 0.8863
Schistosoma mansoni amine GPCR 0.0065 0.8879 0.8863
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0065 0.8879 0.8831
Giardia lamblia PcnA 0.0072 1 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0065 0.8879 0.8863
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.1036 0.0649
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0413 0.0269
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0065 0.8879 0.8863
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.5706 0.5521
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.8879 0.8831
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.1036 0.0649
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0065 0.8879 0.8831
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Onchocerca volvulus 0.0065 0.8879 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0065 0.8879 0.8831
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.1036 0.0649
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Echinococcus multilocularis neuropeptide FF receptor 2 0.0065 0.8879 0.8831
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.1036 0.0649
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0453 0.0042
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.5706 0.5521
Schistosoma mansoni hypothetical protein 0.0065 0.8879 0.8863
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.8879 0.8831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Echinococcus granulosus somatostatin receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus granulosus tachykinin peptides receptor 99D 0.0065 0.8879 0.8831
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis g protein coupled receptor 0.0065 0.8879 0.8831
Schistosoma mansoni hypothetical protein 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0065 0.8879 0.8831
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.1019 0.0632
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.1036 0.0649
Echinococcus multilocularis G-protein coupled receptor, putative 0.0065 0.8879 0.8831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.6312 0.6256
Loa Loa (eye worm) TYRA-2 protein 0.0065 0.8879 0.8831
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.8879 0.8831
Onchocerca volvulus 0.0065 0.8879 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0065 0.8879 0.8831
Brugia malayi Serotonin receptor 0.0065 0.8879 0.8831
Onchocerca volvulus 0.0065 0.8879 1
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.8879 0.8831
Schistosoma mansoni multidrug resistance protein 0.0013 0.1036 0.0901
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0065 0.8879 0.8863
Onchocerca volvulus 0.0065 0.8879 1
Echinococcus multilocularis sex peptide receptor 0.0065 0.8879 0.8831
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis orexin receptor type 2 0.0065 0.8879 0.8831
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.5706 0.5521
Echinococcus multilocularis multidrug resistance protein 1 0.0009 0.0453 0.0042
Onchocerca volvulus 0.0065 0.8879 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.1019 0.0632
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0072 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.1036 0.0649
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0072 1 1
Schistosoma mansoni opsin-like receptor 0.0065 0.8879 0.8863
Brugia malayi Dopamine receptor protein 2 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus granulosus g protein coupled receptor 0.0065 0.8879 0.8831
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0065 0.8879 0.8831
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.1036 0.0649
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.5271 0.5068
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0453 0.0042
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.1036 0.0649
Brugia malayi ABC transporter family protein 0.0013 0.1036 0.0649
Echinococcus granulosus dro:myosuppressin receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0065 0.8879 0.8831
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0038 0.4934 0.4348
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Plasmodium falciparum proliferating cell nuclear antigen 2 0.0038 0.4934 0.4348
Loa Loa (eye worm) hypothetical protein 0.0013 0.1036 0.0649
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.1036 0.0649
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.8879 0.8863
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.1036 0.0649
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0065 0.8879 0.8831
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.1036 0.0649
Onchocerca volvulus 0.0065 0.8879 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0013 0.1036 0.0649
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.5271 0.5068
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0413 0.0269
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.8879 0.8831
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0065 0.8879 0.8831
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0065 0.8879 0.8831
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.1036 0.0649
Trichomonas vaginalis abcb9, putative 0.0013 0.1036 0.0649
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.1036 0.0649
Trichomonas vaginalis taga, putative 0.0013 0.1036 0.0649
Trichomonas vaginalis abcb9, putative 0.0013 0.1036 0.0649
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0065 0.8879 0.8831
Schistosoma mansoni neuropeptide receptor 0.0065 0.8879 0.8863
Echinococcus multilocularis g protein coupled receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.1036 0.0649
Trichomonas vaginalis ABC transporter, putative 0.0013 0.1036 0.0649
Echinococcus multilocularis fmrfamide receptor 0.0065 0.8879 0.8831
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.8879 0.8831
Echinococcus multilocularis neuropeptide receptor 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Echinococcus granulosus g protein coupled receptor 0.0065 0.8879 0.8831
Brugia malayi hypothetical protein 0.0065 0.8879 0.8831
Onchocerca volvulus 0.0065 0.8879 1
Echinococcus multilocularis somatostatin receptor 0.0065 0.8879 0.8831
Trichomonas vaginalis abcb9, putative 0.0013 0.1036 0.0649
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1019 0.0884
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.1036 0.0649
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.8879 0.8863
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0413 0.0269
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1019 0.0884
Brugia malayi RE15519p 0.0065 0.8879 0.8831
Loa Loa (eye worm) hypothetical protein 0.0065 0.8879 0.8831
Brugia malayi multidrug resistance protein 3 0.0013 0.1036 0.0649
Echinococcus granulosus neuropeptide receptor A26 0.0065 0.8879 0.8831
Echinococcus multilocularis neuropeptide receptor A26 0.0065 0.8879 0.8831

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) Inhibition of MRP1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay ChEMBL. 25379609
EC50 (binding) = 1.8 uM Inhibition of MDR1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay ChEMBL. 25379609
Inhibition (binding) Inhibition of BCRP (unknown origin) over-expressed in MDCK cells assessed as Hoechst 33342 accumulation incubated for 30 mins prior to Hoechst 33342 addition measured after 30 mins by fluorescence assay ChEMBL. 25379609

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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