Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.2439 | 0.9096 | 1 | |
Loa Loa (eye worm) | Carm1-pending protein | 0.268 | 1 | 1 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.268 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0319 | 0.1144 | 0.1144 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0319 | 0.1144 | 0.1144 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.0849 | 0.0849 |
Schistosoma mansoni | tyrosine kinase | 0.0099 | 0.0316 | 0.0316 |
Echinococcus granulosus | methyltransferase protein 5 | 0.0241 | 0.0849 | 0.0849 |
Trypanosoma cruzi | arginine N-methyltransferase, type III | 0.0241 | 0.0849 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0235 | 0.0827 | 0.0827 |
Entamoeba histolytica | hypothetical protein | 0.0241 | 0.0849 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0236 | 0.0831 | 0.0831 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.268 | 1 | 1 |
Echinococcus granulosus | insulin receptor | 0.0099 | 0.0316 | 0.0316 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0241 | 0.0849 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0236 | 0.0831 | 0.0831 |
Echinococcus multilocularis | insulin receptor | 0.0099 | 0.0316 | 0.0316 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0241 | 0.0849 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0099 | 0.0316 | 0.0316 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0319 | 0.1144 | 0.1144 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.268 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0236 | 0.0831 | 0.0831 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0241 | 0.0849 | 0.5 |
Loa Loa (eye worm) | protein arginine N-methyltransferase | 0.0241 | 0.0849 | 0.0849 |
Schistosoma mansoni | tyrosine kinase | 0.0235 | 0.0827 | 0.0827 |
Echinococcus multilocularis | 0.0195 | 0.0677 | 0.0677 | |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0849 | 0.0849 |
Trypanosoma cruzi | protein arginine n-methyltransferase 7 | 0.0241 | 0.0849 | 0.5 |
Brugia malayi | Protein arginine N-methyltransferase | 0.0241 | 0.0849 | 0.0849 |
Echinococcus multilocularis | protein arginine N methyltransferase 7 | 0.0241 | 0.0849 | 0.0849 |
Schistosoma mansoni | tyrosine kinase | 0.0236 | 0.0831 | 0.0831 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.268 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0236 | 0.0831 | 0.0831 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0241 | 0.0849 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0099 | 0.0316 | 0.0316 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0241 | 0.0849 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0235 | 0.0827 | 0.0827 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0241 | 0.0849 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0319 | 0.1144 | 0.1144 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0241 | 0.0849 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0319 | 0.1144 | 0.1144 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0241 | 0.0849 | 0.5 |
Leishmania major | arginine N-methyltransferase, type I | 0.0241 | 0.0849 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0099 | 0.0316 | 0.0316 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0241 | 0.0849 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0099 | 0.0316 | 0.0316 |
Brugia malayi | hypothetical protein | 0.0241 | 0.0849 | 0.0849 |
Echinococcus granulosus | protein arginine N methyltransferase 7 | 0.0241 | 0.0849 | 0.0849 |
Entamoeba histolytica | arginine N-methyltransferase 1, putative | 0.0241 | 0.0849 | 0.5 |
Leishmania major | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 | 0.0241 | 0.0849 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0099 | 0.0316 | 0.0316 |
Trypanosoma brucei | protein arginine n-methyltransferase 7 | 0.0241 | 0.0849 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.56 nM | Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assay | ChEMBL. | 25409491 |
IC50 (binding) | = 2.1 nM | Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assay | ChEMBL. | 25409491 |
IC50 (functional) | = 2.06 uM | Antiproliferative activity against human NCI-H1975 cells after 48 hrs by Celltiter-Glo assay | ChEMBL. | 25409491 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25409491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.