Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain containing 2 | Starlite/ChEMBL | References |
Homo sapiens | bromodomain containing 4 | Starlite/ChEMBL | References |
Homo sapiens | bromodomain containing 3 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.1 | Displacement of biotinylated tetra-acetylated histone H4 from His6-tagged BRD2 (1 to 473 aa) (unknown origin) after 1 hr by TR-FRET assay | ChEMBL. | 25249180 |
IC50 (binding) | = 6.3 | Displacement of biotinylated tetra-acetylated histone H4 from His6-tagged BRD3 (1 to 475 aa) (unknown origin) after 1 hr by TR-FRET assay | ChEMBL. | 25249180 |
IC50 (binding) | = 6.3 | Displacement of biotinylated tetra-acetylated histone H4 from His6-tagged BRD4 (1 to 477 aa) (unknown origin) after 1 hr by TR-FRET assay | ChEMBL. | 25249180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.