Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lactate dehydrogenase C | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | lactate dehydrogenase, putative | lactate dehydrogenase C | 332 aa | 307 aa | 29.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0297 | 0.0839 | 1 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0056 | 0.0103 | 0.0103 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0297 | 0.0839 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0056 | 0.0103 | 0.0103 |
Toxoplasma gondii | bicoid-interacting protein BIN3 | 0.0297 | 0.0839 | 0.0743 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0056 | 0.0103 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0056 | 0.0103 | 0.0103 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0056 | 0.0103 | 0.0103 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.3303 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0056 | 0.0103 | 0.0103 |
Echinococcus multilocularis | L lactate dehydrogenase | 0.0034 | 0.0038 | 0.0038 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0297 | 0.0839 | 1 |
Plasmodium falciparum | malate dehydrogenase | 0.0056 | 0.0103 | 1 |
Loa Loa (eye worm) | Carm1-pending protein | 0.3303 | 1 | 1 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0056 | 0.0103 | 0.0103 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0297 | 0.0839 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, type III | 0.0297 | 0.0839 | 1 |
Leishmania major | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 | 0.0297 | 0.0839 | 1 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0056 | 0.0103 | 1 |
Giardia lamblia | Malate dehydrogenase | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable malate dehydrogenase Mdh | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0103 | 0.0103 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.3303 | 1 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0297 | 0.0839 | 1 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.3303 | 1 | 1 |
Chlamydia trachomatis | malate dehydrogenase | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | methyltransferase protein 5 | 0.0297 | 0.0839 | 0.0839 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.3303 | 1 | 1 |
Onchocerca volvulus | 0.3006 | 0.9095 | 0.5 | |
Loa Loa (eye worm) | protein arginine N-methyltransferase | 0.0297 | 0.0839 | 0.0839 |
Plasmodium vivax | lactate dehydrogenase | 0.0056 | 0.0103 | 1 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0297 | 0.0839 | 1 |
Mycobacterium leprae | PROBABLE MALATE DEHYDROGENASE MDH | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | protein arginine N methyltransferase 7 | 0.0297 | 0.0839 | 0.0839 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0297 | 0.0839 | 1 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0297 | 0.0839 | 1 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0056 | 0.0103 | 0.0103 |
Trypanosoma cruzi | protein arginine n-methyltransferase 7 | 0.0297 | 0.0839 | 1 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0297 | 0.0839 | 1 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0056 | 0.0103 | 0.5 |
Brugia malayi | Protein arginine N-methyltransferase | 0.0297 | 0.0839 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.0839 | 0.0839 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0056 | 0.0103 | 0.0103 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.0839 | 0.0839 |
Leishmania major | arginine N-methyltransferase, type I | 0.0297 | 0.0839 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0056 | 0.0103 | 0.0103 |
Leishmania major | malate dehydrogenase, putative | 0.0056 | 0.0103 | 0.1232 |
Echinococcus granulosus | L lactate dehydrogenase | 0.0034 | 0.0038 | 0.0038 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0056 | 0.0103 | 0.0103 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0297 | 0.0839 | 1 |
Brugia malayi | hypothetical protein | 0.0297 | 0.0839 | 0.0839 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0056 | 0.0103 | 0.0103 |
Toxoplasma gondii | histone arginine methyltransferase PRMT3 | 0.0297 | 0.0839 | 0.0743 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0056 | 0.0103 | 0.1232 |
Echinococcus multilocularis | protein arginine N methyltransferase 7 | 0.0297 | 0.0839 | 0.0839 |
Mycobacterium ulcerans | malate dehydrogenase | 0.0022 | 0 | 0.5 |
Brugia malayi | lactate dehydrogenase. | 0.0056 | 0.0103 | 0.0103 |
Entamoeba histolytica | arginine N-methyltransferase 1, putative | 0.0297 | 0.0839 | 1 |
Trypanosoma brucei | protein arginine n-methyltransferase 7 | 0.0297 | 0.0839 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 uM | Inhibition of human LDH-A by biochemical assay | ChEMBL. | 25467161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.