Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fms-related tyrosine kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | maternal embryonic leucine zipper kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0099 | 0.6212 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2338 | 0.2338 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2338 | 0.2338 |
Echinococcus granulosus | calcium activated potassium channel | 0.0049 | 0.2367 | 0.381 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.2367 | 0.2367 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.002 | 0.0132 | 0.0132 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.2367 | 0.2367 |
Schistosoma mansoni | serine/threonine kinase | 0.0148 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0049 | 0.2367 | 0.381 |
Echinococcus granulosus | twitchin | 0.0019 | 0.0029 | 0.0046 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.002 | 0.0132 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.2338 | 0.2338 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0148 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.2367 | 0.2367 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0049 | 0.2367 | 0.381 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0049 | 0.2367 | 0.381 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0099 | 0.6212 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0049 | 0.2338 | 0.3764 |
Brugia malayi | Kinase associated domain 1 family protein | 0.0049 | 0.2338 | 0.2338 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0049 | 0.2367 | 0.381 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0049 | 0.2367 | 0.381 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.2367 | 0.2367 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.2367 | 0.2367 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 37 nM | Inhibition of MELK (unknown origin) | ChEMBL. | 25589926 |
IC50 (binding) | = 0.037 uM | Inhibition of MELK kinase (unknown origin) using biotinylated ZIP-tide peptide/gamma[33P]ATP by scintillation counting analysis | ChEMBL. | 25589925 |
IC50 (binding) | = 18 uM | Inhibition of Flt3 (unknown origin) by Millipore kinase analysis | ChEMBL. | 25589925 |
IC50 (binding) | = 23 uM | Inhibition of MELK kinase (unknown origin) using KKLNRTLSFAEPG/gamma[33P]ATP by Millipore kinase/scintillation counting analysis | ChEMBL. | 25589925 |
IC50 (binding) | = 760 uM | Inhibition of Mnk2 (unknown origin) by Millipore kinase analysis | ChEMBL. | 25589925 |
IC50 (binding) | = 810 uM | Inhibition of CAMK2delta (unknown origin) by Millipore kinase analysis | ChEMBL. | 25589925 |
IC50 (binding) | = 1000 uM | Inhibition of MLCK (unknown origin) by Millipore kinase analysis | ChEMBL. | 25589925 |
IC50 (binding) | = 1000 uM | Inhibition of CAMK2gamma (unknown origin) by Millipore kinase analysis | ChEMBL. | 25589925 |
Inhibition (binding) | = -12 % | Inhibition of AMPKalpha2 (unknown origin) at 1 uM by Millipore kinase analysis | ChEMBL. | 25589925 |
Inhibition (binding) | = 5 % | Inhibition of AMPKalpha1 (unknown origin) at 1 uM by Millipore kinase analysis | ChEMBL. | 25589925 |
Inhibition (binding) | = 54 % | Inhibition of MLCK (unknown origin) at 1 uM by Millipore kinase analysis | ChEMBL. | 25589925 |
Inhibition (binding) | = 55 % | Inhibition of CAMK2gamma (unknown origin) at 1 uM by Millipore kinase analysis | ChEMBL. | 25589925 |
Inhibition (binding) | = 59 % | Inhibition of Mnk2 (unknown origin) at 1 uM by Millipore kinase analysis | ChEMBL. | 25589925 |
Inhibition (binding) | = 60 % | Inhibition of CAMK2delta (unknown origin) at 1 uM by Millipore kinase analysis | ChEMBL. | 25589925 |
Inhibition (binding) | = 90 % | Inhibition of Flt3 (unknown origin) at 1 uM by Millipore kinase analysis | ChEMBL. | 25589925 |
Inhibition (binding) | = 97 % | Inhibition of MELK kinase (unknown origin) using KKLNRTLSFAEPG/gamma[33P]ATP at 1 uM by Millipore kinase/scintillation counting analysis | ChEMBL. | 25589925 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.