Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gabp alpha | 0.007 | 0.0596 | 0.2048 |
Echinococcus granulosus | GA binding protein alpha chain | 0.007 | 0.0596 | 0.209 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.4919 | 0.4912 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.245 | 0.2438 |
Echinococcus granulosus | serotonin transporter | 0.0148 | 0.1694 | 0.5938 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0723 | 0.0709 |
Onchocerca volvulus | 0.0035 | 0.0099 | 0.0297 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0081 | 0.0754 | 0.074 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0164 | 0.1921 | 0.6743 |
Onchocerca volvulus | 0.023 | 0.2842 | 1 | |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.0099 | 0.0296 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2046 | 0.1027 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.0061 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1694 | 0.1682 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0539 | 0.1847 |
Brugia malayi | Fli-1 protein | 0.0213 | 0.261 | 0.2599 |
Brugia malayi | hypoxia-induced factor 1 | 0.0146 | 0.1663 | 0.1651 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0131 | 0.1452 | 0.509 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0148 | 0.1694 | 0.1682 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.023 | 0.2853 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0148 | 0.1694 | 0.5917 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0148 | 0.1694 | 0.1682 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1836 | 0.1824 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5552 | 0.5546 |
Loa Loa (eye worm) | serotonin transporter b | 0.0148 | 0.1694 | 0.1682 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0081 | 0.0754 | 0.2643 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0738 | 1 | 0.5 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.0272 | 0.0904 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.245 | 0.2438 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0148 | 0.1694 | 0.1682 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1694 | 0.1682 |
Echinococcus multilocularis | serotonin receptor | 0.0131 | 0.1452 | 0.5064 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.007 | 0.0596 | 0.2048 |
Onchocerca volvulus | 0.0148 | 0.1694 | 0.5939 | |
Onchocerca volvulus | 0.0064 | 0.0508 | 0.1743 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2046 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Echinococcus granulosus | jun protein | 0.0081 | 0.0754 | 0.2643 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.007 | 0.0596 | 0.0582 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.0099 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.0061 | 0.0046 |
Brugia malayi | hypothetical protein | 0.0064 | 0.0508 | 0.0494 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.025 | 0.3134 | 0.3124 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1452 | 0.1439 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.0099 | 0.0347 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.2838 | 0.2827 |
Brugia malayi | hypothetical protein | 0.0106 | 0.11 | 0.1086 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.0099 | 0.0084 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0015 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1694 | 0.1682 |
Brugia malayi | Ets-domain containing protein | 0.007 | 0.0596 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.5552 | 0.5546 |
Echinococcus multilocularis | serotonin receptor | 0.0131 | 0.1452 | 0.5064 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0738 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0081 | 0.0754 | 0.2604 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.025 | 0.3134 | 0.3124 |
Schistosoma mansoni | jun-related protein | 0.0066 | 0.0539 | 0.1847 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0148 | 0.1694 | 0.5917 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0453 | 0.0439 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0015 | 0.5 |
Brugia malayi | hypothetical protein | 0.0158 | 0.1836 | 0.1824 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.023 | 0.2853 | 1 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.0272 | 0.0257 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.023 | 0.2853 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0015 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0213 | 0.261 | 0.2599 |
Echinococcus multilocularis | jun protein | 0.0081 | 0.0754 | 0.2604 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0148 | 0.1694 | 0.5 |
Schistosoma mansoni | single-minded | 0.0047 | 0.0272 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1452 | 0.1439 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0148 | 0.1694 | 0.5917 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0146 | 0.1663 | 0.1651 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.2842 | 0.7593 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0131 | 0.1452 | 0.5064 |
Brugia malayi | Ets-domain containing protein | 0.007 | 0.0596 | 0.0582 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.3134 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.023 | 0.2853 | 0.2842 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0738 | 1 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.2838 | 0.2827 |
Schistosoma mansoni | ets-related | 0.0213 | 0.261 | 0.9143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.