Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Schistosoma japonicum | ko:K04165 Oamb gene product from transcript, putative | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0363 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0533 | 0.0455 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0363 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0533 | 0.0455 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.4103 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0533 | 0.0455 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.4103 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.4103 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0533 | 0.0455 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.4103 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.4103 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0533 | 0.0455 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.4103 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.4103 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 24 nM | Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting | ChEMBL. | 18507369 |
Ki (binding) | = 103 nM | Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting | ChEMBL. | 18507369 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.