Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0042 | 0.0081 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0546 | 0.05 |
Echinococcus granulosus | Immunoglobulin | 0.0036 | 0.0049 | 0.0049 |
Schistosoma mansoni | nephrin | 0.0041 | 0.0073 | 0.0079 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.062 | 0.3079 | 0.3045 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0054 | 0.014 | 0.014 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0258 | 0.1203 | 0.1203 |
Brugia malayi | map kinase activated protein kinase protein 2 | 0.062 | 0.3079 | 0.3045 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.0762 | 0.0762 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.1952 | 1 | 1 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0068 | 0.0215 | 0.0168 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.1952 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.0355 | 0.1012 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.0762 | 1 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.018 | 0.0797 | 0.5 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.062 | 0.3079 | 0.3079 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.0355 | 0.0355 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0258 | 0.1203 | 0.116 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.0762 | 0.2353 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0073 | 0.0024 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.0762 | 0.0716 |
Echinococcus granulosus | neuroglian | 0.0041 | 0.0073 | 0.0073 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.1952 | 1 | 0.5 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.062 | 0.3079 | 0.3045 |
Loa Loa (eye worm) | raf kinase | 0.0252 | 0.1171 | 0.1128 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.1952 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.1952 | 1 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0036 | 0.0049 | 0.0049 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.004 | 0.0067 | 0.0018 |
Echinococcus multilocularis | roundabout 2 | 0.0041 | 0.0073 | 0.0024 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0036 | 0.0049 | 0.0049 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.1952 | 1 | 1 |
Echinococcus granulosus | WGR domain containing protein | 0.0054 | 0.014 | 0.014 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0082 | 0.0288 | 0.0792 |
Schistosoma mansoni | serine/threonine protein kinase | 0.062 | 0.3079 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0042 | 0.0081 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0073 | 0.0024 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.1952 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0258 | 0.1203 | 0.3809 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0355 | 0.0308 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.1952 | 1 | 1 |
Brugia malayi | Raf kinase | 0.025 | 0.1157 | 0.1114 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.1952 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.005 | 0.0121 | 0.0121 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.1298 | 0.6604 | 0.6604 |
Brugia malayi | WGR domain containing protein | 0.0095 | 0.0355 | 0.0308 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.0355 | 0.0308 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.0762 | 0.0716 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0149 | 0.0632 | 0.0587 |
Echinococcus multilocularis | neuroglian | 0.0041 | 0.0073 | 0.0024 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.1952 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.1952 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0041 | 0.0073 | 0.0073 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.