Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1D | References | |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 2, surface | References | |
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1B | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Alpha-1D adrenergic receptor, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma mansoni | amine GPCR | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.438 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.2992 | 0.683 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0073 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0073 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0073 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0073 | 0 | 0.5 |
Onchocerca volvulus | 0.0248 | 0.5133 | 1 | |
Echinococcus granulosus | aminopeptidase N | 0.0248 | 0.5133 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0248 | 0.5133 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0201 | 0.3745 | 0.8549 |
Brugia malayi | Peptidase family M1 containing protein | 0.0248 | 0.5133 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0073 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0073 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0073 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0073 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0073 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0073 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 5.17 | In vitro blocking activity against beta adrenergic receptor, isolated from guinea pig atria | ChEMBL. | 6115059 |
Kd (binding) | = 5.47 | In vitro blocking activity against alpha adrenergic receptor, isolated from rabbit aortic strip | ChEMBL. | 6115059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.