Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin D | Starlite/ChEMBL | References |
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Homo sapiens | beta-site APP-cleaving enzyme 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | cathepsin D | 412 aa | 339 aa | 28.9 % |
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Plasmodium falciparum | plasmepsin V | beta-site APP-cleaving enzyme 2 | 518 aa | 439 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fli-1 protein | 0.0212 | 0.337 | 0.534 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0356 | 0.6138 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0101 | 0.1217 | 0.1021 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0347 | 0.0248 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.359 | 0.3365 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0101 | 0.1217 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0347 | 0.0248 |
Schistosoma mansoni | gabp alpha | 0.007 | 0.0621 | 0.0283 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0056 | 0.0347 | 0.0248 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0101 | 0.1217 | 0.5 |
Schistosoma mansoni | ets-related | 0.0212 | 0.337 | 0.3132 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0134 | 0.1863 | 0.3292 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0216 | 0.3436 | 0.32 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0101 | 0.1217 | 0.1021 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.007 | 0.0621 | 0.0709 |
Toxoplasma gondii | hypothetical protein | 0.0497 | 0.8867 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0101 | 0.1217 | 0.215 |
Treponema pallidum | polypeptide deformylase (def) | 0.0497 | 0.8867 | 0.5 |
Brugia malayi | Pepsin A precursor | 0.0056 | 0.0347 | 0.0248 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0056 | 0.0347 | 0.0248 |
Plasmodium falciparum | plasmepsin IV | 0.0101 | 0.1217 | 0.1021 |
Brugia malayi | Ets-domain containing protein | 0.007 | 0.0621 | 0.0709 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0347 | 0.0248 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0356 | 0.6138 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0134 | 0.1863 | 0.157 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0356 | 0.6138 | 1 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0056 | 0.0347 | 0.0248 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0134 | 0.1863 | 0.3292 |
Onchocerca volvulus | 0.0056 | 0.0347 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0134 | 0.1863 | 0.28 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0356 | 0.6138 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0134 | 0.1863 | 0.157 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.007 | 0.0621 | 0.1097 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0101 | 0.1217 | 0.1021 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0101 | 0.1217 | 0.1713 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0056 | 0.0347 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1217 | 0.1713 |
Plasmodium falciparum | peptide deformylase | 0.0497 | 0.8867 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0101 | 0.1217 | 0.1021 |
Loa Loa (eye worm) | fli-1 protein | 0.0212 | 0.337 | 0.534 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0101 | 0.1217 | 0.215 |
Plasmodium vivax | peptide deformylase, putative | 0.0497 | 0.8867 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0101 | 0.1217 | 0.1021 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0425 | 0.0379 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0347 | 0.0248 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0134 | 0.1863 | 0.28 |
Mycobacterium ulcerans | peptide deformylase | 0.0497 | 0.8867 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0497 | 0.8867 | 1 |
Brugia malayi | Ets-domain containing protein | 0.007 | 0.0621 | 0.0709 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0056 | 0.0347 | 0.0248 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0497 | 0.8867 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.5658 | 0.5501 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0134 | 0.1863 | 0.157 |
Echinococcus granulosus | geminin | 0.0331 | 0.5658 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0497 | 0.8867 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.1097 | 0.0231 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.1097 | 0.0231 |
Echinococcus multilocularis | geminin | 0.0331 | 0.5658 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.1097 | 0.0231 |
Chlamydia trachomatis | peptide deformylase | 0.0497 | 0.8867 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.278 | 0.4346 |
Plasmodium falciparum | plasmepsin I | 0.0101 | 0.1217 | 0.1021 |
Onchocerca volvulus | 0.0056 | 0.0347 | 0.5 | |
Echinococcus granulosus | GA binding protein alpha chain | 0.007 | 0.0621 | 0.1097 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0134 | 0.1863 | 0.3292 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.1097 | 0.0231 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0216 | 0.3436 | 0.32 |
Plasmodium vivax | plasmepsin IV, putative | 0.0101 | 0.1217 | 0.1021 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.5658 | 0.5501 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.6138 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0134 | 0.1863 | 0.3292 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.3 nM | Inhibition of recombinant memapsin 2 | ChEMBL. | 19323561 |
Ki (binding) | = 0.3 nM | Inhibition of recombinant BACE1 (unknown origin) | ChEMBL. | 25537272 |
Ki (binding) | = 131 nM | Inhibition of cathepsin D | ChEMBL. | 19323561 |
Ki (binding) | = 356 nM | Inhibition of memapsin 1 | ChEMBL. | 19323561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.