Detailed information for compound 955347

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.262 | Formula: C16H12O7
  • H donors: 4 H acceptors: 5 LogP: 2.28 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(O)c2c(c1O)oc(cc2=O)c1ccc(c(c1)O)O
  • InChi: 1S/C16H12O7/c1-22-13-6-11(20)14-10(19)5-12(23-16(14)15(13)21)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3
  • InChiKey: SQYJGJIGIBPVLM-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Aldose reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   316 aa 320 aa 19.7 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 330 aa 18.8 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   316 aa 334 aa 24.3 %
Onchocerca volvulus Aldose reductase   316 aa 314 aa 37.3 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   316 aa 309 aa 26.9 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 281 aa 29.2 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   316 aa 295 aa 21.4 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 281 aa 29.2 %
Onchocerca volvulus Aldose reductase   316 aa 321 aa 40.2 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 277 aa 37.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 330 aa 18.8 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 329 aa 19.8 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 277 aa 37.2 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   316 aa 320 aa 40.3 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   316 aa 335 aa 24.2 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   316 aa 296 aa 26.7 %
Leishmania braziliensis aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   316 aa 267 aa 27.3 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.8236 0.9216
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Trypanosoma brucei prostaglandin f synthase 0.0038 0.8937 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.1017 0.1137
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.8972 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.8937 0.996
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.1017 0.1137
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0011 0.1017 0.1137
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.8937 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.8972 1
Plasmodium falciparum aldo-keto reductase, putative 0.0011 0.1017 0.5
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.8937 1
Schistosoma mansoni aldo-keto reductase 0.0038 0.8937 0.8937
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.8937 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.8972 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.8937 0.996
Echinococcus multilocularis aldehyde reductase 0.0027 0.5707 0.6361
Loa Loa (eye worm) oxidoreductase 0.0038 0.8937 0.996
Plasmodium vivax aldehyde reductase, putative 0.0011 0.1017 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Entamoeba histolytica aldose reductase, putative 0.0038 0.8937 1
Toxoplasma gondii aldose reductase, putative 0.0038 0.8937 1
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.5707 0.5922
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.8236 0.9216
Onchocerca volvulus 0.0038 0.8937 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.1017 0.1137
Onchocerca volvulus 0.0038 0.8937 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.8937 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0011 0.1017 0.1133
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Leishmania major aldo-keto reductase-like protein 0.0038 0.8937 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Echinococcus multilocularis aldo keto reductase 0.0038 0.8937 0.996
Onchocerca volvulus 0.0038 0.8937 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.8937 0.996
Loa Loa (eye worm) hypothetical protein 0.0038 0.8937 0.996
Loa Loa (eye worm) oxidoreductase 0.0038 0.8937 0.996
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.8937 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.8937 0.996
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.8937 0.996
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.7495 0.8354
Echinococcus multilocularis voltage gated potassium channel subunit 0.0011 0.1017 0.1133
Loa Loa (eye worm) hypothetical protein 0.0011 0.1028 0.1145
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Echinococcus granulosus hypothetical protein 0.0038 0.8937 0.996
Echinococcus granulosus aldo keto reductase 0.0038 0.8937 0.996
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0011 0.1017 0.1133
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.1028 0.1145
Entamoeba histolytica aldose reductase, putative 0.0038 0.8937 1
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.1028 0.1145
Mycobacterium ulcerans oxidoreductase 0.0038 0.8937 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.8972 1
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.1028 0.1028
Giardia lamblia Aldose reductase 0.0038 0.8937 0.5
Giardia lamblia Aldose reductase 0.0038 0.8937 0.5
Echinococcus granulosus voltage gated potassium channel 0.0011 0.1028 0.1145
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.1028 0.1145
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.1028 0.1028
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.8937 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Leishmania major prostaglandin f synthase, putative 0.0038 0.8937 1
Schistosoma mansoni potassium channel beta 0.0011 0.1017 0.1017
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0011 0.1017 0.1137
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.8937 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.1028 0.1145
Schistosoma mansoni aldo-keto reductase 0.0038 0.8937 0.8937
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.8937 1
Schistosoma mansoni pol-related 0.0038 0.8937 0.8937
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.8937 0.996
Brugia malayi NADH-dependent xylose reductase 0.0011 0.1017 0.1133
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Trypanosoma cruzi aldo-keto reductase 0.0038 0.8937 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Entamoeba histolytica aldose reductase, putative 0.0038 0.8937 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0011 0.1017 0.1133
Echinococcus multilocularis aldo keto reductase 0.0038 0.8937 0.996
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0011 0.1017 0.5
Echinococcus granulosus aldehyde reductase 0.0027 0.5707 0.6361
Onchocerca volvulus 0.0038 0.8937 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0011 0.1017 0.1133
Onchocerca volvulus 0.0038 0.8937 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.8937 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Plasmodium falciparum aldehyde reductase, putative 0.0011 0.1017 0.5
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.8937 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.8937 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.8937 0.996
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Onchocerca volvulus 0.0038 0.8937 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.8937 0.996
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.8937 0.996
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.8937 1
Echinococcus granulosus aldo keto reductase 0.0038 0.8937 0.996
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.8937 0.996
Schistosoma mansoni voltage-gated potassium channel 0.0042 1 1
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.8937 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.8937 0.996
Echinococcus granulosus aldo keto reductase 0.0038 0.8937 0.996

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.64 Inhibition of rat lens aldose reductase ChEMBL. 18585047

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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