TDR Targets

Basic information

Technical information

TDR Targets ID: 955694
Name: 1,5,8-trimethyl-3a,4-dihydroazuleno[5,6-d]fur an-2,6-dione
MW: 242.27 | Formula: C15H14O3
H donors: 0 H acceptors: 2 LogP: 0.9 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: CC1=C2C=C3C(=CC(=O)C3=C(CC2OC1=O)C)C
InChi: 1S/C15H14O3/c1-7-4-12(16)14-8(2)5-13-11(6-10(7)14)9(3)15(17)18-13/h4,6,13H,5H2,1-3H3
InChiKey: BAHMQESJBKGPTE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1,5,8-trimethyl-3a,4-dihydroazuleno[5,6-d]furan-2,6-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2847	0.6768
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0238	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0599	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0599	0.1193
Echinococcus granulosus	cathepsin l1	0.0013	0.011	0.0179
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0085	0.2847	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0346	0.0348
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1385	0.1385
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0066	0.0066
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.1011	0.1651
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0238	0.024
Schistosoma mansoni	hypothetical protein	0.0172	0.6125	0.6125
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.011	0.1087
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0599	1
Onchocerca volvulus		0.0019	0.0346	0.0861
Onchocerca volvulus		0.0019	0.0346	0.0861
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.2348	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0013	0.011	0.0261
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0238	0.024
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0238	0.5
Brugia malayi	Cathepsin L-like precursor	0.0013	0.011	0.0261
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.0346	0.5772
Echinococcus multilocularis	peroxidasin	0.0085	0.2847	0.2866
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0346	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0596	0.1416
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.4207	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0346	0.0346
Brugia malayi	hypothetical protein	0.0036	0.1011	0.2404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0346	1
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0238	0.3979
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0346	0.0821
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0238	0.0313
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0238	0.0238
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0346	0.0821
Loa Loa (eye worm)	animal heme peroxidase	0.0085	0.2847	0.6682
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1385	0.1385
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.1385	0.3293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Brugia malayi	Peroxidasin	0.0085	0.2847	0.6768
Onchocerca volvulus	Peroxidasin homolog	0.0085	0.2847	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1385	0.2262
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.2348	1
Onchocerca volvulus		0.0019	0.0346	0.0861
Plasmodium vivax	vivapain-2	0.0019	0.0346	0.5772
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0346	0.0564
Echinococcus granulosus	cathepsin l1	0.0019	0.0346	0.0564
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0238	0.3979
Brugia malayi	MH2 domain containing protein	0.0121	0.4207	1
Plasmodium vivax	vivapain-2	0.0019	0.0346	0.5772
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0346	0.0821
Echinococcus multilocularis	cysteine protease	0.0019	0.0346	0.0348
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0346	0.0861
Leishmania major	hypothetical protein, conserved	0.0026	0.0599	0.1708
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2847	0.6768
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0599	0.2549
Schistosoma mansoni	peroxidasin	0.0085	0.2847	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0346	0.1472
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1385	0.2262
Brugia malayi	hypothetical protein	0.0085	0.2847	0.6768
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0346	0.3417
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0346	0.0861
Onchocerca volvulus	Peroxidase homolog	0.0085	0.2847	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0346	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.0346	0.5772
Leishmania major	cathepsin L-like protease	0.0072	0.2348	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.1767	0.7525
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Entamoeba histolytica	hypothetical protein	0.0036	0.1011	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.011	0.3182
Loa Loa (eye worm)	animal heme peroxidase	0.0085	0.2847	0.6682
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Onchocerca volvulus		0.0019	0.0346	0.0861
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0238	0.0566
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0238	0.0389
Schistosoma mansoni	hypothetical protein	0.0036	0.1011	0.1011
Onchocerca volvulus		0.0019	0.0346	0.0861
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0346	0.0346
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.2112	0.8997
Onchocerca volvulus	Peroxidasin homolog	0.0085	0.2847	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Entamoeba histolytica	hypothetical protein	0.0036	0.1011	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0346	0.0821
Onchocerca volvulus	Peroxidase homolog	0.0085	0.2847	1
Leishmania major	cathepsin L-like protease	0.0019	0.0346	0.0509
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0238	0.024
Loa Loa (eye worm)	ctsf protein	0.0019	0.0346	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.0346	0.5772
Echinococcus multilocularis	geminin	0.0172	0.6125	0.6166
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2847	0.6768
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.2348	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0072	0.2348	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.4207	1
Echinococcus multilocularis	conserved hypothetical protein	0.0273	0.9933	1
Brugia malayi	Cathepsin L-like precursor	0.0013	0.011	0.0261
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0346	0.0348
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0346	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0238	0.1014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Onchocerca volvulus	Dual oxidase homolog	0.0085	0.2847	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Echinococcus granulosus	peroxidasin	0.0085	0.2847	0.4649
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0599	0.2549
Loa Loa (eye worm)	animal heme peroxidase	0.0085	0.2847	0.6682
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Brugia malayi	hypothetical protein	0.0017	0.0256	0.0609
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0346	0.3417
Brugia malayi	hypothetical protein	0.0026	0.0599	0.1423
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Leishmania major	cathepsin L-like protease	0.0019	0.0346	0.0509
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Leishmania major	cathepsin L-like protease	0.0072	0.2348	1
Onchocerca volvulus		0.0019	0.0346	0.0861
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1385	0.1385
Leishmania major	cathepsin L-like protease	0.0072	0.2348	1
Onchocerca volvulus		0.0085	0.2847	1
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2847	0.6768
Echinococcus granulosus	geminin	0.0172	0.6125	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0013	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Onchocerca volvulus		0.0085	0.2847	1
Loa Loa (eye worm)	fibroinase	0.0019	0.0346	0.0575
Onchocerca volvulus		0.0019	0.0346	0.0861
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0238	0.024
Schistosoma mansoni	hypothetical protein	0.0011	0.0066	0.0066
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0346	0.0861
Echinococcus multilocularis	conserved hypothetical protein	0.0273	0.9933	1
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0346	0.0821
Schistosoma mansoni	peroxidasin	0.0085	0.2847	0.2847
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0346	0.0821
Entamoeba histolytica	hypothetical protein	0.0036	0.1011	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0599	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Entamoeba histolytica	hypothetical protein	0.0036	0.1011	1
Echinococcus multilocularis	cysteine protease	0.0019	0.0346	0.0348
Leishmania major	cathepsin L-like protease	0.0019	0.0346	0.0509
Leishmania major	cysteine peptidase A (CPA)	0.0019	0.0346	0.0509
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0346	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Loa Loa (eye worm)	cysteine protease	0.0019	0.0346	0.0575
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0346	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0346	0.0575
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0238	0.0566
Brugia malayi	cathepsin L-like precursor	0.0013	0.011	0.0261
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0238	0.1014
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1385	0.1395
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0596	0.1185
Schistosoma mansoni	hypothetical protein	0.0172	0.6125	0.6125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Onchocerca volvulus		0.0085	0.2847	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0346	0.0348
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.011	0.3182
Brugia malayi	Blistered cuticle protein 3	0.0085	0.2847	0.6768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0238	0.1014
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0066	0.0108
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.1011	0.1011
Loa Loa (eye worm)	blistered cuticle protein 3	0.0085	0.2847	0.6682
Loa Loa (eye worm)	animal heme peroxidase	0.0085	0.2847	0.6682
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1385	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0599	0.2549
Brugia malayi	Animal haem peroxidase family protein	0.0085	0.2847	0.6768
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0599	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.1385	0.3113
Toxoplasma gondii	cathepsin CPL	0.0019	0.0346	0.2978
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0346	0.3417
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0346	0.0575
Leishmania major	cathepsin L-like protease	0.0019	0.0346	0.0509
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0072	0.2348	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0346	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.1011	0.1018
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0238	0.024
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2847	0.6682
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0346	1
Leishmania major	cathepsin L-like protease	0.0019	0.0346	0.0509

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL449951

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 955694