Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | fk506-binding protein 1-like protein | 0.0107 | 0.0283 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0107 | 0.0283 | 0.0283 |
Echinococcus multilocularis | cation chloride cotransporter | 0.02 | 0.0921 | 0.1002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Loa Loa (eye worm) | glutaminase 2 | 0.0294 | 0.1559 | 0.1559 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Mycobacterium tuberculosis | Probable GABA permease GabP (4-amino butyrate transport carrier) (GAMA-aminobutyrate permease) | 0.02 | 0.0921 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Schistosoma mansoni | immunophilin | 0.0107 | 0.0283 | 0.0308 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0107 | 0.0283 | 0.0308 |
Echinococcus granulosus | cation chloride cotransporter | 0.02 | 0.0921 | 0.1002 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0107 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Brugia malayi | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0107 | 0.0283 | 0.5 |
Mycobacterium ulcerans | L-asparagine permease AnsP1 | 0.02 | 0.0921 | 0.4998 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0107 | 0.0283 | 0.0308 |
Brugia malayi | Amino acid permease family protein | 0.1408 | 0.9187 | 0.9187 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Brugia malayi | Hypothetical 112.3 kDa protein K02A2.3 in chromosome II | 0.1408 | 0.9187 | 0.9187 |
Mycobacterium ulcerans | GabA permease GabP | 0.02 | 0.0921 | 0.4998 |
Schistosoma mansoni | glutaminase | 0.0294 | 0.1559 | 0.1697 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Onchocerca volvulus | Solute carrier family 12 member 8 homolog | 0.02 | 0.0921 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0294 | 0.1559 | 0.1559 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0107 | 0.0283 | 0.5 |
Brugia malayi | solute carrier family 12 member 1 | 0.02 | 0.0921 | 0.0921 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0294 | 0.1559 | 1 |
Onchocerca volvulus | Solute carrier family 12 member 9 homolog | 0.02 | 0.0921 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0107 | 0.0283 | 0.0308 |
Loa Loa (eye worm) | solute carrier family 12 member 1 | 0.02 | 0.0921 | 0.0921 |
Mycobacterium tuberculosis | Probable D-serine/alanine/glycine transporter protein CycA | 0.02 | 0.0921 | 0.5 |
Mycobacterium ulcerans | D-serine/D-alanine/glycine transporter, CycA | 0.02 | 0.0921 | 0.4998 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Schistosoma mansoni | immunophilin | 0.0092 | 0.0182 | 0.0198 |
Mycobacterium tuberculosis | Possible L-asparagine permease AnsP2 (L-asparagine transport protein) | 0.02 | 0.0921 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Echinococcus multilocularis | solute carrier family 12 | 0.1408 | 0.9187 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0092 | 0.0182 | 0.0198 |
Schistosoma mansoni | solute carrier family 12 k-cl cotransporter | 0.02 | 0.0921 | 0.1002 |
Trichomonas vaginalis | lysine-specific permease, putative | 0.02 | 0.0921 | 0.4998 |
Schistosoma mansoni | cation chloride cotransporter | 0.02 | 0.0921 | 0.1002 |
Trichomonas vaginalis | gaba permease, putative | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1527 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Loa Loa (eye worm) | amino acid permease | 0.1408 | 0.9187 | 0.9187 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0092 | 0.0182 | 0.0198 |
Trichomonas vaginalis | aromatic amino acid transporter, putative | 0.02 | 0.0921 | 0.4998 |
Mycobacterium ulcerans | glutaminase | 0.0294 | 0.1559 | 1 |
Schistosoma mansoni | immunophilin | 0.0107 | 0.0283 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Brugia malayi | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.02 | 0.0921 | 0.4998 |
Echinococcus multilocularis | fk506 binding protein | 0.0107 | 0.0283 | 0.0308 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0107 | 0.0283 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Mycobacterium leprae | POSSIBLE L-ASPARAGINE PERMEASE ANSP1 (L-ASPARAGINE TRANSPORT PROTEIN) | 0.02 | 0.0921 | 0.5 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.02 | 0.0921 | 0.4998 |
Brugia malayi | Amino acid permease family protein | 0.02 | 0.0921 | 0.0921 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0107 | 0.0283 | 0.0283 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Mycobacterium leprae | POSSIBLE L-ASPARAGINE PERMEASE ANSP2 (L-ASPARAGINE TRANSPORT PROTEIN) | 0.02 | 0.0921 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.1408 | 0.9187 | 1 |
Echinococcus granulosus | solute carrier family 12 | 0.1408 | 0.9187 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0294 | 0.1559 | 0.1559 |
Loa Loa (eye worm) | FKBP5 protein | 0.0107 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0343 | 0.0343 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0107 | 0.0283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0107 | 0.0283 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0107 | 0.0283 | 0.0308 |
Trichomonas vaginalis | amino acid permease, putative | 0.02 | 0.0921 | 0.4998 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0107 | 0.0283 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antiprotozoan activity against Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hr prior to [3H]hypoxanthine addition measured after 18 hr by liquid scintillation counting | ChEMBL. | No reference | |
IC50 (functional) | = 56.3 uM | Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay | ChEMBL. | 18226429 |
IC50 (functional) | > 100 uM | Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay | ChEMBL. | 18226429 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.