Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | POSSIBLE L-ASPARAGINE PERMEASE ANSP1 (L-ASPARAGINE TRANSPORT PROTEIN) | 0.02 | 0.0921 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0107 | 0.0283 | 0.5 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.02 | 0.0921 | 0.4998 |
Echinococcus multilocularis | fk506 binding protein | 0.0107 | 0.0283 | 0.0308 |
Brugia malayi | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0343 | 0.0343 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0107 | 0.0283 | 0.0283 |
Brugia malayi | Amino acid permease family protein | 0.02 | 0.0921 | 0.0921 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.02 | 0.0921 | 0.4998 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.1408 | 0.9187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Mycobacterium leprae | POSSIBLE L-ASPARAGINE PERMEASE ANSP2 (L-ASPARAGINE TRANSPORT PROTEIN) | 0.02 | 0.0921 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0294 | 0.1559 | 0.1559 |
Echinococcus granulosus | solute carrier family 12 | 0.1408 | 0.9187 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0107 | 0.0283 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | FKBP5 protein | 0.0107 | 0.0283 | 0.0283 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0107 | 0.0283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Trichomonas vaginalis | amino acid permease, putative | 0.02 | 0.0921 | 0.4998 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0107 | 0.0283 | 0.0308 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0107 | 0.0283 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Trichomonas vaginalis | lysine-specific permease, putative | 0.02 | 0.0921 | 0.4998 |
Schistosoma mansoni | solute carrier family 12 k-cl cotransporter | 0.02 | 0.0921 | 0.1002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0092 | 0.0182 | 0.0198 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Echinococcus multilocularis | solute carrier family 12 | 0.1408 | 0.9187 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Trichomonas vaginalis | gaba permease, putative | 0.02 | 0.0921 | 0.4998 |
Schistosoma mansoni | cation chloride cotransporter | 0.02 | 0.0921 | 0.1002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1527 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Schistosoma mansoni | immunophilin | 0.0107 | 0.0283 | 0.0308 |
Mycobacterium ulcerans | glutaminase | 0.0294 | 0.1559 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0092 | 0.0182 | 0.0198 |
Trichomonas vaginalis | aromatic amino acid transporter, putative | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | amino acid permease | 0.1408 | 0.9187 | 0.9187 |
Brugia malayi | glutaminase DH11.1 | 0.0294 | 0.1559 | 0.1559 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0107 | 0.0283 | 0.5 |
Onchocerca volvulus | Solute carrier family 12 member 8 homolog | 0.02 | 0.0921 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Brugia malayi | solute carrier family 12 member 1 | 0.02 | 0.0921 | 0.0921 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Trichomonas vaginalis | glutaminase, putative | 0.0294 | 0.1559 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Mycobacterium tuberculosis | Probable D-serine/alanine/glycine transporter protein CycA | 0.02 | 0.0921 | 0.5 |
Loa Loa (eye worm) | solute carrier family 12 member 1 | 0.02 | 0.0921 | 0.0921 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0107 | 0.0283 | 0.0308 |
Onchocerca volvulus | Solute carrier family 12 member 9 homolog | 0.02 | 0.0921 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Mycobacterium ulcerans | D-serine/D-alanine/glycine transporter, CycA | 0.02 | 0.0921 | 0.4998 |
Schistosoma mansoni | immunophilin | 0.0092 | 0.0182 | 0.0198 |
Mycobacterium tuberculosis | Possible L-asparagine permease AnsP2 (L-asparagine transport protein) | 0.02 | 0.0921 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0107 | 0.0283 | 0.5 |
Echinococcus multilocularis | cation chloride cotransporter | 0.02 | 0.0921 | 0.1002 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0107 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Loa Loa (eye worm) | glutaminase 2 | 0.0294 | 0.1559 | 0.1559 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Mycobacterium tuberculosis | Probable GABA permease GabP (4-amino butyrate transport carrier) (GAMA-aminobutyrate permease) | 0.02 | 0.0921 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0107 | 0.0283 | 0.5 |
Echinococcus granulosus | cation chloride cotransporter | 0.02 | 0.0921 | 0.1002 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0107 | 0.0283 | 0.0308 |
Schistosoma mansoni | immunophilin | 0.0107 | 0.0283 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.1208 | 0.7816 | 0.7816 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0107 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0107 | 0.0283 | 0.5 |
Brugia malayi | hypothetical protein | 0.02 | 0.0921 | 0.0921 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.0921 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.1408 | 0.9187 | 0.9187 |
Brugia malayi | Amino acid permease family protein | 0.1408 | 0.9187 | 0.9187 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0107 | 0.0283 | 0.0308 |
Mycobacterium ulcerans | L-asparagine permease AnsP1 | 0.02 | 0.0921 | 0.4998 |
Mycobacterium ulcerans | GabA permease GabP | 0.02 | 0.0921 | 0.4998 |
Brugia malayi | Hypothetical 112.3 kDa protein K02A2.3 in chromosome II | 0.1408 | 0.9187 | 0.9187 |
Schistosoma mansoni | glutaminase | 0.0294 | 0.1559 | 0.1697 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antiprotozoan activity against Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hr prior to [3H]hypoxanthine addition measured after 18 hr by liquid scintillation counting | ChEMBL. | No reference | |
IC50 (functional) | > 100 uM | Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay | ChEMBL. | 18226429 |
IC50 (functional) | > 100 uM | Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay | ChEMBL. | 18226429 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.