Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0135 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0417 | 0.0981 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1526 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1678 | 0.3948 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1526 | 0.359 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1526 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.425 | 1 |
Treponema pallidum | hypothetical protein | 0.028 | 1 | 0.5 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.028 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.425 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0135 | 0.0316 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0417 | 0.0981 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1094 | 0.2575 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0135 | 0.0316 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1526 | 0.359 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0417 | 0.2031 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1094 | 0.2575 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.028 | 1 | 0.5 |
Brugia malayi | Smad1 | 0.0008 | 0.0135 | 0.0316 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0417 | 0.2031 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.028 | 1 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0417 | 0.2031 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0417 | 0.2031 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1526 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0135 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1094 | 0.6899 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1678 | 0.3948 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0417 | 0.2031 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0135 | 0.0316 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.028 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1526 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0135 | 0.0316 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1678 | 0.3948 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0417 | 0.0981 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0417 | 0.2031 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0135 | 0.0316 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1526 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0417 | 0.2031 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1678 | 0.3948 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0417 | 0.2031 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0417 | 0.0981 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1526 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.425 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0417 | 0.2031 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1526 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0417 | 0.2031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.81 uM | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 25529734 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25529734 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.