TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 371.399 | Formula: C21H20F3N3
H donors: 0 H acceptors: 1 LogP: 4.63 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1cnc2c(c1)c(cc(c2)C(F)(F)F)c1ccccc1
InChi: 1S/C21H20F3N3/c1-26-7-9-27(10-8-26)17-13-19-18(15-5-3-2-4-6-15)11-16(21(22,23)24)12-20(19)25-14-17/h2-6,11-14H,7-10H2,1H3
InChiKey: HNJPBQIQJGUESM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Echinococcus granulosus	plexin a4	0.0025	0.0042	0.0037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Onchocerca volvulus		0.0044	0.0258	0.1825
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0021	0.0005	0.0005
Schistosoma mansoni	cathepsin s	0.0023	0.0022	0.0022
Brugia malayi	Blistered cuticle protein 3	0.0128	0.1187	0.1187
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0258	0.0258
Giardia lamblia	Cathepsin B precursor	0.0107	0.0954	1
Brugia malayi	plexin A	0.0025	0.0042	0.0042
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0299	0.3071	0.3071
Trypanosoma cruzi	cysteine proteinase, putative	0.0044	0.0258	0.0825
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0107	0.0954	1
Schistosoma mansoni	tyrosine kinase	0.049	0.5191	0.5191
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Loa Loa (eye worm)	animal heme peroxidase	0.0131	0.1213	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0143	0.0143
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0107	0.0954	0.3093
Onchocerca volvulus	Peroxidasin homolog	0.0131	0.1213	0.8578
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Onchocerca volvulus		0.0021	0.0005	0.0038
Trypanosoma cruzi	cysteine protease, putative	0.0044	0.0258	0.0825
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0316	0.0316
Echinococcus granulosus	epidermal growth factor receptor	0.0499	0.5281	0.5279
Schistosoma mansoni	tyrosine kinase	0.026	0.2647	0.2647
Echinococcus granulosus	protein tyrosine kinase	0.026	0.2647	0.2643
Schistosoma mansoni	hypothetical protein	0.0034	0.0143	0.0143
Toxoplasma gondii	cathepsin CPL	0.0044	0.0258	0.2667
Echinococcus multilocularis	cathepsin b	0.0299	0.3071	0.3067
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0044	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Plasmodium vivax	vivapain-3	0.0044	0.0258	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0021	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.0258	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0022	0.0022
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0258	0.0258
Schistosoma mansoni	tyrosine kinase	0.049	0.5191	0.5191
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0021	0.0005	0.0005
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0258	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0258	0.0825
Loa Loa (eye worm)	animal heme peroxidase	0.0128	0.1187	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0258	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.0258	0.2667
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Echinococcus multilocularis	epidermal growth factor receptor	0.0499	0.5281	0.5279
Brugia malayi	Papain family cysteine protease containing protein	0.0021	0.0005	0.0005
Schistosoma mansoni	tyrosine kinase	0.0499	0.5281	0.5281
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0258	0.0825
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.0258	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Schistosoma mansoni	cathepsin S (C01 family)	0.0021	0.0005	0.0005
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0258	0.1825
Echinococcus granulosus	cathepsin b	0.0299	0.3071	0.3067
Onchocerca volvulus		0.0021	0.0005	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Schistosoma mansoni	tyrosine kinase	0.0499	0.5281	0.5281
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Onchocerca volvulus	Dual oxidase homolog	0.0128	0.1187	0.8392
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Loa Loa (eye worm)	plexin A	0.0025	0.0042	0.0042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0298	0.3061	0.3057
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0258	0.0258
Schistosoma mansoni	peroxidasin	0.0131	0.1221	0.1221
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0044	0.0258	1
Onchocerca volvulus		0.0128	0.1187	0.8392
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Plasmodium vivax	unspecified product	0.0044	0.0258	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0299	0.3071	0.3071
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0258	1
Onchocerca volvulus	Cathepsin L homolog	0.0021	0.0005	0.0038
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0021	0.0005	0.0005
Brugia malayi	cathepsin F-like cysteine proteinase	0.0021	0.0005	0.0005
Onchocerca volvulus		0.0044	0.0258	0.1825
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0107	0.0954	1
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0149	0.1415	1
Onchocerca volvulus	Peroxidase homolog	0.0128	0.1187	0.8392
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0021	0.0005	0.0005
Echinococcus granulosus	cysteine protease	0.0044	0.0258	0.0253
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0159	0.1525	0.1525
Echinococcus granulosus	peroxidasin	0.0134	0.1247	0.1242
Brugia malayi	Animal haem peroxidase family protein	0.0128	0.1187	0.1187
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Loa Loa (eye worm)	blistered cuticle protein 3	0.0128	0.1187	0.1187
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0143	0.0143
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Onchocerca volvulus		0.0128	0.1187	0.8392
Onchocerca volvulus		0.0044	0.0258	0.1825
Echinococcus multilocularis	cathepsin L	0.0044	0.0258	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0022	0.0022
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0021	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Brugia malayi	Papain family cysteine protease containing protein	0.0021	0.0005	0.0005
Onchocerca volvulus		0.0128	0.1187	0.8392
Schistosoma mansoni	cathepsin B (C01 family)	0.0021	0.0005	0.0005
Brugia malayi	Animal haem peroxidase family protein	0.0128	0.1187	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Trypanosoma cruzi	cruzipain precursor, putative	0.0023	0.0022	0.0055
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Brugia malayi	Protein kinase domain containing protein	0.0298	0.3061	0.3061
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0023	0.0022	0.0022
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0258	1
Echinococcus multilocularis	cysteine protease	0.0044	0.0258	0.0253
Loa Loa (eye worm)	ctsf protein	0.0044	0.0258	0.0258
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Onchocerca volvulus		0.0138	0.1298	0.9177
Brugia malayi	Animal haem peroxidase family protein	0.0128	0.1187	0.1187
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Loa Loa (eye worm)	animal heme peroxidase	0.0128	0.1187	0.1187
Brugia malayi	Protein kinase domain containing protein	0.0263	0.268	0.268
Echinococcus multilocularis	cathepsin b	0.0299	0.3071	0.3067
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0316	0.0316
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0258	0.0258
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0044	0.0258	0.0825
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0021	0.0005	0.0005
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0022	0.0055
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0023	0.0022	0.0022
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0021	0.0005	0.0005
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0044	0.0258	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0044	0.0258	1
Onchocerca volvulus		0.0044	0.0258	0.1825
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0258	0.0258
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0258	0.1825
Brugia malayi	cathepsin L precursor	0.0021	0.0005	0.0005
Echinococcus granulosus	epidermal growth factor receptor	0.0925	1	1
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Schistosoma mansoni	tyrosine kinase	0.0925	1	1
Giardia lamblia	Cathepsin B precursor	0.0107	0.0954	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0258	0.0825
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Schistosoma mansoni	cathepsin C	0.0021	0.0005	0.0005
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Echinococcus multilocularis	insulin receptor	0.0298	0.3061	0.3057
Brugia malayi	cathepsin F-like cysteine proteinase	0.0023	0.0022	0.0022
Onchocerca volvulus	Chorion peroxidase homolog	0.0128	0.1187	0.8392
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0299	0.3071	0.3071
Onchocerca volvulus		0.0044	0.0258	0.1825
Loa Loa (eye worm)	cysteine protease	0.0044	0.0258	0.0258
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0044	0.0258	0.0253
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.0258	0.0253
Brugia malayi	hypothetical protein	0.0128	0.1187	0.1187
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Brugia malayi	fibroinase precursor	0.0021	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0258	0.0258
Onchocerca volvulus		0.0044	0.0258	0.1825
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0299	0.3071	0.3071
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0258	1
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0258	0.0825
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0258	0.0825
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0258	0.0258
Entamoeba histolytica	cysteine proteinase 1, putative	0.0044	0.0258	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Toxoplasma gondii	cathepsin B	0.0107	0.0954	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0258	0.0258
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0021	0.0005	0.0005
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0022	0.0022
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0299	0.3071	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Schistosoma mansoni	tyrosine kinase	0.049	0.5191	0.5191
Giardia lamblia	Cathepsin B precursor	0.0107	0.0954	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.0258	0.0253
Schistosoma mansoni	tyrosine kinase	0.0298	0.3061	0.3061
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0021	0.0005	0.0005
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Plasmodium vivax	vivapain-1	0.0044	0.0258	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0925	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Loa Loa (eye worm)	TK/FAK protein kinase	0.0263	0.268	0.268
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0005
Echinococcus granulosus	cathepsin L	0.0044	0.0258	0.0253
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0021	0.0005	0.0005
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Brugia malayi	Papain family cysteine protease containing protein	0.0021	0.0005	0.0005
Entamoeba histolytica	cysteine proteinase 2	0.0044	0.0258	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0021	0.0005	0.0005
Brugia malayi	Animal haem peroxidase family protein	0.0131	0.1213	0.1213
Echinococcus multilocularis	peroxidasin	0.0134	0.1247	0.1242
Onchocerca volvulus	Cathepsin F homolog	0.0044	0.0258	0.1825
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Brugia malayi	Animal haem peroxidase family protein	0.0128	0.1187	0.1187
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0258	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0258	1
Loa Loa (eye worm)	fibroinase	0.0044	0.0258	0.0258
Schistosoma mansoni	cathepsin F (C01 family)	0.0021	0.0005	0.0005
Echinococcus multilocularis		0.0286	0.2926	0.2922
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0021	0.0005	0.0005
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0044	0.0258	1
Schistosoma mansoni	tyrosine kinase	0.0298	0.3061	0.3061
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Brugia malayi	cathepsin L-like precursor	0.0021	0.0005	0.0005
Trypanosoma cruzi	cruzipain precursor, putative	0.0044	0.0258	0.0825
Schistosoma mansoni	peroxidasin	0.0128	0.1187	0.1187
Loa Loa (eye worm)	TK/INSR protein kinase	0.0298	0.3061	0.3061
Onchocerca volvulus	Peroxidase homolog	0.0128	0.1187	0.8392
Loa Loa (eye worm)	cathepsin B	0.0107	0.0954	0.0954
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0005	0.0005
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Echinococcus granulosus	cathepsin l1	0.0044	0.0258	0.0253
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0021	0.0005	0.0005
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0258	0.0258
Plasmodium vivax	unspecified product	0.0023	0.0022	0.0668
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Loa Loa (eye worm)	animal heme peroxidase	0.0128	0.1187	0.1187
Echinococcus granulosus	cathepsin b	0.0299	0.3071	0.3067
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0299	0.3071	0.3071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0298	0.3061	0.3057
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0316	0.0316
Brugia malayi	Peroxidasin	0.0134	0.1247	0.1247
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0159	0.1525	0.1525
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0258	0.2667
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0499	0.5281	0.5279
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0021	0.0005	0.0005
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0925	1	1
Echinococcus granulosus	insulin receptor	0.0298	0.3061	0.3057
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0258	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0021	0.0005	0.0005
Echinococcus granulosus	cathepsin L cysteine protease	0.0044	0.0258	0.0253
Onchocerca volvulus		0.0044	0.0258	0.1825
Echinococcus multilocularis	cysteine protease	0.0044	0.0258	0.0253
Echinococcus multilocularis	plexin a4	0.0025	0.0042	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0299	0.3071	0.3071
Echinococcus multilocularis	protein tyrosine kinase	0.026	0.2647	0.2643
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0258	0.0258
Plasmodium vivax	vivapain-2	0.0044	0.0258	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0044	0.0258	0.0825
Brugia malayi	cathepsin L-like cysteine proteinase	0.0021	0.0005	0.0005
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0107	0.0954	0.0954
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0258	0.2667
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.0258	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0107	0.0954	1
Plasmodium vivax	vivapain-2	0.0044	0.0258	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1187	0.1187
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0044	0.0258	0.0253
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0258	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0316	0.0316
Onchocerca volvulus	Peroxidasin homolog	0.0131	0.1213	0.8578

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 650 nM	Inhibition of human c-MET	ChEMBL.	21641696
IC50 (binding)	= 0.65 uM	Inhibition of human recombinant his-tagged c-Met by TR-FRET assay	ChEMBL.	19059779

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL456720

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 957661