Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.160506 | 0.304616 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.474704 | 1 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.474704 | 1 | 1 |
Echinococcus granulosus | Endonuclease G | 0.0293754 | 0.014397 | 0.014397 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.160506 | 0.304616 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.160506 | 0.304616 | 0.5 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.160506 | 0.304616 | 0.304616 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.160506 | 0.304616 | 1 |
Echinococcus granulosus | ectonucleotide | 0.041576 | 0.0413995 | 0.0413995 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Loa Loa (eye worm) | hypothetical protein | 0.0491026 | 0.0580574 | 0.0580574 |
Echinococcus multilocularis | Endonuclease G | 0.0293754 | 0.014397 | 0.014397 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.160506 | 0.304616 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.474704 | 1 | 1 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0475165 | 0.054547 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.11299 | 0.199453 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0475165 | 0.054547 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0437189 | 0.0461422 | 0.032209 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.160506 | 0.304616 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.106744 | 0.18563 | 0.18563 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.474704 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Loa Loa (eye worm) | hypothetical protein | 0.0491026 | 0.0580574 | 0.0580574 |
Onchocerca volvulus | 0.106744 | 0.18563 | 0.517411 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0475165 | 0.054547 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Schistosoma mansoni | hypothetical protein | 0.106744 | 0.18563 | 0.18563 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Loa Loa (eye worm) | hypothetical protein | 0.041576 | 0.0413995 | 0.0413995 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.474704 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.106744 | 0.18563 | 0.173734 |
Echinococcus multilocularis | ectonucleotide | 0.041576 | 0.0413995 | 0.0413995 |
Loa Loa (eye worm) | hypothetical protein | 0.0491026 | 0.0580574 | 0.0580574 |
Leishmania major | hypothetical protein, conserved | 0.0475165 | 0.054547 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.160506 | 0.304616 | 0.5 |
Schistosoma mansoni | endonuclease related | 0.0293754 | 0.014397 | 0.014397 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.160506 | 0.304616 | 0.294459 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.160506 | 0.304616 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.041576 | 0.0413995 | 0.0413995 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Onchocerca volvulus | 0.160506 | 0.304616 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.041576 | 0.0413995 | 0.0413995 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.160506 | 0.304616 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.160506 | 0.304616 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0491026 | 0.0580574 | 0.0580574 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0491026 | 0.0580574 | 0.0442982 |
Loa Loa (eye worm) | hypothetical protein | 0.0427121 | 0.0439138 | 0.0439138 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0293754 | 0.014397 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as parasite-free survival at 25 mg/kg, po administered on day 3 to 6 after infection measured on day 60 | ChEMBL. | 18455271 | |
Activity (functional) | = 20.25 day | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as average survival days at 25 mg/kg, po administered on day 3 to 6 after infection | ChEMBL. | 18455271 |
IC50 (functional) | = 8.9 nM | Antiprotozoal activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 72 hrs by [3H]hypoxanthine uptake | ChEMBL. | 18455271 |
IC50 (functional) | = 7500 nM | Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 bloodstream form after 72 hrs by alamar blue assay | ChEMBL. | 18455271 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 18455271 | ||
Trypanosoma brucei gambiense | 18455271 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.