Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | UNCoordinated family member | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.008 | 0.4641 | 0.4641 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Brugia malayi | Hexokinase family protein | 0.0096 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK protein kinase | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0096 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.008 | 0.4641 | 0.4641 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | lethal protein 805 | 0.008 | 0.4641 | 0.4641 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | myotactin form A | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Schistosoma mansoni | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | projectin | 0.008 | 0.4641 | 0.4641 |
Plasmodium falciparum | hexokinase | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4641 | 0.4641 |
Onchocerca volvulus | 0.0096 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.48 | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli assessed as maximal activating response by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay relative to 2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(4-methylthiazol-2-yl)benzamide in presence of 2.5 mM glucose | ChEMBL. | 19282189 |
Activity (binding) | = 0.48 | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli assessed as maximal activating response by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay relative to 2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(4-methylthiazol-2-yl)benzamide in presence of 10 mM glucose | ChEMBL. | 19282189 |
EC50 (binding) | = 1.1 uM | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose | ChEMBL. | 19282189 |
EC50 (binding) | = 18 uM | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose | ChEMBL. | 19282189 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.