Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0166 | 0.1307 | 0.4185 | |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0359 | 0.3122 | 0.3122 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.01 | 0.0681 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0199 | 0.1617 | 1 |
Leishmania major | endonuclease G, putative | 0.01 | 0.0681 | 1 |
Onchocerca volvulus | 0.0166 | 0.1307 | 0.4185 | |
Trypanosoma brucei | endonuclease G, putative | 0.01 | 0.0681 | 1 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0138 | 0.1038 | 0.5 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0166 | 0.1307 | 0.1307 |
Onchocerca volvulus | 0.0199 | 0.1617 | 0.5178 | |
Trypanosoma brucei | endonuclease G, putative | 0.01 | 0.0681 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 0.1617 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 0.1617 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.014 | 0.106 | 0.106 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0359 | 0.3122 | 0.3122 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0061 | 0.0318 | 0.197 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1307 | 0.1307 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.01 | 0.0681 | 0.0681 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.014 | 0.106 | 0.106 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.109 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1307 | 0.1307 |
Trypanosoma cruzi | endonuclease G, putative | 0.01 | 0.0681 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.109 | 1 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.01 | 0.0681 | 1 |
Onchocerca volvulus | 0.0359 | 0.3122 | 1 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.109 | 1 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.01 | 0.0681 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 0.1617 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 0.1617 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 0.1617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1307 | 0.1307 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0199 | 0.1617 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0199 | 0.1617 | 0.1617 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.01 | 0.0681 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.106 | 0.106 |
Echinococcus granulosus | Endonuclease G | 0.01 | 0.0681 | 0.0681 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0061 | 0.0318 | 0.4675 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.014 | 0.106 | 0.106 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0199 | 0.1617 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0061 | 0.0318 | 0.4675 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Echinococcus granulosus | ectonucleotide | 0.014 | 0.106 | 0.106 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0199 | 0.1617 | 0.1617 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.109 | 1 | 1 |
Schistosoma mansoni | endonuclease related | 0.01 | 0.0681 | 0.0681 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 0.1617 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.0318 | 0.4675 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.01 | 0.0681 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0359 | 0.3122 | 0.3122 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0199 | 0.1617 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0061 | 0.0318 | 0.197 |
Echinococcus multilocularis | Endonuclease G | 0.01 | 0.0681 | 0.0681 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1307 | 0.1307 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.0318 | 0.4675 |
Trypanosoma cruzi | endonuclease G, putative | 0.01 | 0.0681 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 100 mg kg-1 | Anticonvulsant activity in ip dosed CF1 albino mouse assessed as inhibition of maximal electroshock-induced electrical stimulus after 1 hr | ChEMBL. | 18375131 |
Activity (functional) | = 300 mg kg-1 | Anticonvulsant activity in ip dosed CF1 albino mouse assessed as inhibition of maximal electroshock-induced electrical stimulus after 0.5 hr | ChEMBL. | 18375131 |
Activity (functional) | = 300 mg kg-1 | Anticonvulsant activity in ip dosed CF1 albino mouse assessed as inhibition of maximal electroshock-induced electrical stimulus after 4 hrs | ChEMBL. | 18375131 |
Activity (ADMET) | = 300 mg kg-1 | Neurotoxicity in ip dosed CF1 albino mouse after 0.5 hr by rotarod test | ChEMBL. | 18375131 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.