Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.037 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.037 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0062 | 0.0861 | 0.0834 |
Loa Loa (eye worm) | carboxylesterase | 0.037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0861 | 0.0834 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0062 | 0.0861 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.037 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.0861 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0861 | 0.0834 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0861 | 0.0861 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0062 | 0.0861 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0861 | 0.0861 |
Echinococcus granulosus | acetylcholinesterase | 0.037 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0062 | 0.0861 | 0.0519 |
Onchocerca volvulus | 0.0062 | 0.0861 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0062 | 0.0861 | 0.0834 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0861 | 0.0519 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0062 | 0.0861 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0861 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0861 | 0.0834 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0861 | 0.0519 |
Onchocerca volvulus | 0.0062 | 0.0861 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0861 | 0.0834 |
Schistosoma mansoni | gliotactin | 0.0062 | 0.0861 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0861 | 0.0834 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0062 | 0.0861 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0861 | 0.0519 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0062 | 0.0861 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0861 | 0.0861 |
Echinococcus granulosus | carboxylesterase 5A | 0.037 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0.0861 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.037 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0062 | 0.0861 | 0.0519 |
Brugia malayi | Carboxylesterase family protein | 0.037 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0.0861 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.0861 | 1 | |
Brugia malayi | hypothetical protein | 0.0062 | 0.0861 | 0.0861 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0062 | 0.0861 | 0.0519 |
Onchocerca volvulus | 0.0062 | 0.0861 | 1 | |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.2254 | 0.2254 |
Echinococcus granulosus | neuroligin | 0.0062 | 0.0861 | 0.0519 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0861 | 0.0834 |
Schistosoma mansoni | acetylcholinesterase | 0.0062 | 0.0861 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2254 | 0.2231 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0062 | 0.0861 | 0.0519 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0062 | 0.0861 | 0.0519 |
Echinococcus multilocularis | neuroligin | 0.0062 | 0.0861 | 0.0519 |
Echinococcus granulosus | acetylcholinesterase | 0.037 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0062 | 0.0861 | 0.0519 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0861 | 0.0861 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0062 | 0.0861 | 0.0519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.