Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.02 | 0.0754 | 0.0497 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Loa Loa (eye worm) | hyaluronidase | 0.1122 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.02 | 0.0754 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.02 | 0.0754 | 0.0497 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.02 | 0.0754 | 0.5 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.1122 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.1122 | 1 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.3526 | 0.3347 |
Schistosoma mansoni | Hyaluronidase | 0.1122 | 1 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.02 | 0.0754 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.1122 | 1 | 1 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.02 | 0.0754 | 0.0754 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.02 | 0.0754 | 0.0754 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0125 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.02 | 0.0754 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.6 nM | Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human p38alpha by fluorescence polarization | ChEMBL. | 18602262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.