Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | Involved in protection against oxidative damage | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.0275 | 1 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0344 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0275 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0344 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0156 | 0.5405 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.3971 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0344 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0344 | 0.0866 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0344 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.3969 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0344 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.3969 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0344 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0344 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.3971 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.3971 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0275 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 52 nM | inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 20299219 |
Kinact (binding) | = 6.7 10'6nM | Inhibition of human recombinant CA3 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 7.6 nM | Inhibition of human recombinant CA14 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 28 nM | Inhibition of mouse recombinant CA15 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 55 nM | Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 60.5 nM | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 61 nM | Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 62 nM | Inhibition of human recombinant CA7 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 104 nM | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 690 nM | Inhibition of human recombinant CA5B by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 727 nM | Inhibition of human recombinant CA5A by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 738 nM | Inhibition of mouse recombinant CA13 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 3035 nM | Inhibition of human recombinant CA4 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Kinact (binding) | = 4230 nM | Inhibition of human recombinant CA6 by stopped-flow CO2 hydration method | ChEMBL. | 18819811 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.