Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0362 | 0.9802 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0208 | 0.2948 | 0.227 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0367 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0362 | 0.9802 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0362 | 0.9802 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0362 | 0.9802 | 0.9719 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0367 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0367 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0362 | 0.9802 | 0.9719 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0367 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0362 | 0.9802 | 0.9719 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0367 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0362 | 0.9802 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0362 | 0.9802 | 0.9783 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0362 | 0.9802 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0228 | 0.3827 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.2948 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2633 | 0.1924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 95 nM | Inhibition of human plasma DPP4 | ChEMBL. | 18602260 |
IC50 (binding) | = 2130 nM | Inhibition of DPP8 | ChEMBL. | 18602260 |
IC50 (binding) | = 3030 nM | Inhibition of DPP9 | ChEMBL. | 18602260 |
IC50 (binding) | = 18300 nM | Inhibition of PPCE | ChEMBL. | 18602260 |
IC50 (binding) | = 21800 nM | Inhibition of DPP2 | ChEMBL. | 18602260 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.