Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0007 | 0.0007 | 0.5 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.001 | 0.0065 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0065 | 0.0058 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0065 | 0.0111 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0007 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.375 | 0.375 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.001 | 0.0065 | 0.0058 |
Onchocerca volvulus | 0.001 | 0.0065 | 0.0146 | |
Trypanosoma cruzi | hypothetical protein | 0.0007 | 0.0007 | 0.5 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0065 | 0.0065 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0007 | 0.0007 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor | 0.0007 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0953 | 0.0953 |
Brugia malayi | hypothetical protein | 0.0269 | 0.5202 | 0.5199 |
Giardia lamblia | Kinesin-5 | 0.0029 | 0.0444 | 0.5 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.001 | 0.0065 | 0.0065 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0029 | 0.0444 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0065 | 0.0111 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.001 | 0.0065 | 0.0111 |
Brugia malayi | hypothetical protein | 0.001 | 0.0065 | 0.0058 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.001 | 0.0065 | 0.0111 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0511 | 1 | 1 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0007 | 0.0007 | 0.5 |
Brugia malayi | DIX domain containing protein | 0.001 | 0.0065 | 0.0058 |
Schistosoma mansoni | kinesin eg-5 | 0.0029 | 0.0444 | 0.0444 |
Brugia malayi | N-terminal motif family protein | 0.0205 | 0.3939 | 0.3935 |
Brugia malayi | Kinesin motor domain containing protein | 0.0029 | 0.0444 | 0.0438 |
Brugia malayi | hypothetical protein | 0.001 | 0.0065 | 0.0058 |
Trypanosoma cruzi | hypothetical protein | 0.0007 | 0.0007 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0029 | 0.0444 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.3939 | 0.3935 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.001 | 0.0065 | 0.0111 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0065 | 0.0111 |
Schistosoma mansoni | dishevelled | 0.001 | 0.0065 | 0.0065 |
Plasmodium falciparum | kinesin-5 | 0.0029 | 0.0444 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0007 | 0.0007 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.001 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.001 | 0.0065 | 0.0058 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.001 | 0.0065 | 0.0111 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.001 | 0.0065 | 0.0111 |
Echinococcus multilocularis | kinesin family 1 | 0.0225 | 0.4331 | 0.8323 |
Entamoeba histolytica | kinesin, putative | 0.0029 | 0.0444 | 1 |
Schistosoma mansoni | dep domain containing protein | 0.001 | 0.0065 | 0.0065 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.001 | 0.0065 | 0.0146 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.0953 | 0.0946 |
Schistosoma mansoni | regulator of G protein signaling | 0.001 | 0.0065 | 0.0065 |
Onchocerca volvulus | 0.0055 | 0.0953 | 0.2405 | |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0205 | 0.3939 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0269 | 0.5202 | 1 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0007 | 0.0007 |
Echinococcus granulosus | kinesin family 1 | 0.0225 | 0.4331 | 0.8323 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0007 | 0.0007 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0511 | 1 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0065 | 0.0058 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0269 | 0.5202 | 1 |
Plasmodium vivax | kinesin-5 | 0.0029 | 0.0444 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0065 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0065 | 0.0058 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0007 | 0.0007 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0007 | 0.0007 | 0.0007 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0065 | 0.0111 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.001 | 0.0065 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.5202 | 0.5199 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.001 | 0.0065 | 0.0111 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.02 uM | Antiproliferative activity against mouse 3T3 cells expressing human CSF1R after 72 hrs by Celltiter assay | ChEMBL. | 19114305 |
Activity (binding) | = 7.6 uM | Inhibition of human ERG | ChEMBL. | 19114305 |
Inhibition (functional) | = 65 % | Inhibition of phosphorylated CSF1R level in 3T3/CSF1R mutant cells xenografted nude mouse at 25 mg/kg, po after 6 hrs by ELISA | ChEMBL. | 19114305 |
Inhibition (functional) | = 85 % | Inhibition of phosphorylated CSF1R level in 3T3/CSF1R mutant cells xenografted nude mouse at 25 mg/kg, po after 2 hrs by ELISA | ChEMBL. | 19114305 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.