Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0362 | 0.7003 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0362 | 0.7003 | 0.9783 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0228 | 0.2734 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0362 | 0.7003 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0362 | 0.7003 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0367 | 0.7145 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0367 | 0.7145 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0362 | 0.7003 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0208 | 0.2107 | 0.227 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0362 | 0.7003 | 0.6203 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0367 | 0.7145 | 0.6382 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0362 | 0.7003 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0367 | 0.7145 | 0.6382 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0367 | 0.7145 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1881 | 0.1924 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0367 | 0.7145 | 0.6382 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0362 | 0.7003 | 0.6203 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0362 | 0.7003 | 0.6203 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.2107 | 0.227 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 78 nM | Inhibition of human plasma DPP4 | ChEMBL. | 18602260 |
IC50 (binding) | = 525 nM | Inhibition of DPP9 | ChEMBL. | 18602260 |
IC50 (binding) | = 3400 nM | Inhibition of DPP8 | ChEMBL. | 18602260 |
IC50 (binding) | = 6420 nM | Inhibition of DPP2 | ChEMBL. | 18602260 |
IC50 (binding) | > 10000 nM | Inhibition of PPCE | ChEMBL. | 18602260 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.