TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 470.516 | Formula: C28H26N2O5
H donors: 1 H acceptors: 1 LogP: 4.15 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1OC)OC)C1=C(CNC1=O)c1cn(c2c1cccc2)COc1ccccc1
InChi: 1S/C28H26N2O5/c1-32-24-13-18(14-25(33-2)27(24)34-3)26-21(15-29-28(26)31)22-16-30(23-12-8-7-11-20(22)23)17-35-19-9-5-4-6-10-19/h4-14,16H,15,17H2,1-3H3,(H,29,31)
InChiKey: GCWMGQFAGIVZCJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TEK tyrosine kinase, endothelial	Starlite/ChEMBL	References
Homo sapiens	polo-like kinase 4	Starlite/ChEMBL	References
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	fms-related tyrosine kinase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase PLK4, putative	Get druggable targets OG5_134726	All targets in OG5_134726
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase PLK4, putative	Get druggable targets OG5_134726	All targets in OG5_134726
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	Serine:threonine protein kinase PLK4	Get druggable targets OG5_134726	All targets in OG5_134726
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	kinase	Get druggable targets OG5_134726	All targets in OG5_134726
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	Get druggable targets OG5_134726	All targets in OG5_134726
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0421	0.3013
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0402	0.2876
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0071	0.0421	0.3013
Entamoeba histolytica	protein kinase, putative	0.0068	0.0402	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0019	0.0011	0.0044
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0047	0.0233	0.0078
Schistosoma mansoni	cell adhesion molecule	0.0024	0.0048	0.0318
Brugia malayi	serine/threonine-protein kinase plk-2	0.0059	0.0323	0.1042
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	0.0135	0.093	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.0402	0.4321
Schistosoma mansoni	cathepsin D (A01 family)	0.0139	0.0961	0.6923
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.0402	0.1305
Toxoplasma gondii	kringle domain-containing protein	0.0065	0.0371	0.0218
Echinococcus multilocularis	neuroglian	0.0019	0.0011	0.0114
Entamoeba histolytica	protein kinase, putative	0.0068	0.0402	1
Echinococcus granulosus	Serine:threonine protein kinase PLK4	0.0135	0.093	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Leishmania major	protein kinase, putative	0.0068	0.0402	1
Echinococcus granulosus	twitchin	0.0019	0.0007	0.0079
Echinococcus multilocularis	tissue type plasminogen activator	0.0065	0.0371	0.3984
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0402	1
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0323	0.5322
Echinococcus granulosus	roundabout 2	0.003	0.01	0.107
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0156	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0012
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.1368
Toxoplasma gondii	aurora kinase	0.0068	0.0402	0.0249
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0019	0.0011	0.0114
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0421	0.3013
Onchocerca volvulus		0.0071	0.0421	0.0962
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0156	0.0486
Echinococcus granulosus	glycoprotein Antigen 5	0.0071	0.0421	0.4524
Echinococcus granulosus	neuroglian	0.0019	0.0011	0.0114
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0421	0.3013
Brugia malayi	Trypsin family protein	0.0071	0.0421	0.1368
Echinococcus granulosus	transmembrane protease serine 3	0.0071	0.0421	0.4524
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0011	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0371	0.1201
Echinococcus multilocularis	transmembrane protease serine 3	0.0071	0.0421	0.4524
Loa Loa (eye worm)	TK/ROR protein kinase	0.0075	0.045	0.1465
Echinococcus granulosus	roundabout 2	0.0019	0.0011	0.0114
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0486
Schistosoma mansoni	neuroglian	0.0019	0.0011	0.0044
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0398	0.3009	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0486
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0059	0.0323	0.1042
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0019	0.0011	0.0114
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0071	0.0421	0.1368
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.0402	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0486
Schistosoma mansoni	protein kinase	0.0068	0.0402	0.2876
Schistosoma mansoni	cathepsin D (A01 family)	0.0139	0.0961	0.6923
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0019	0.0011	0.0114
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0421	0.4524
Echinococcus granulosus	contactin	0.0019	0.0011	0.0114
Leishmania major	hypothetical protein, conserved	0.0065	0.0371	0.603
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.1368
Brugia malayi	Trypsin family protein	0.0071	0.0421	0.1368
Schistosoma mansoni	hypothetical protein	0.0071	0.0421	0.3013
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0402	1
Giardia lamblia	Aurora kinase	0.0068	0.0402	1
Loa Loa (eye worm)	trypsin family protein	0.0071	0.0421	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0486
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0071	0.0421	0.4524
Echinococcus granulosus	aurora kinase A	0.0068	0.0402	0.4321
Onchocerca volvulus		0.0065	0.0371	0.0779
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0402	1
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0323	0.5322
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0059	0.0323	0.3473
Plasmodium falciparum	cysteine repeat modular protein 1	0.0065	0.0371	0.8143
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.1368
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.0402	0.4321
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.0402	0.1305
Echinococcus multilocularis	Mastin	0.0071	0.0421	0.4524
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0421	0.3013
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0156	0.0486
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0019	0.0011	0.0114
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0402	1
Schistosoma mansoni	nephrin	0.0019	0.0011	0.0044
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0402	0.1305
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0065	0.0371	0.8143
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0071	0.0421	0.4524
Echinococcus granulosus	enteropeptidase	0.0071	0.0421	0.4524
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0047	0.0233	0.0743
Echinococcus granulosus	roundabout 2	0.0019	0.0011	0.0114
Toxoplasma gondii	PAN domain-containing protein	0.0349	0.2618	0.25
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0486
Echinococcus multilocularis	glycoprotein Antigen 5	0.0071	0.0421	0.4524
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.1368
Schistosoma mansoni	nephrin	0.0022	0.0034	0.0215
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0323	0.5322
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0019	0.0011	0.0114
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0059	0.0323	0.0606
Toxoplasma gondii	PAN domain-containing protein	0.0349	0.2618	0.25
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Onchocerca volvulus		0.0071	0.0421	0.0962
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0156	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0065	0.0182
Onchocerca volvulus	Tyrosine kinase homolog	0.0385	0.2906	1
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0047	0.0233	0.1656
Brugia malayi	Trypsin-like protease protein 5	0.0071	0.0421	0.1368
Schistosoma mansoni	kinase	0.0193	0.1386	1
Entamoeba histolytica	protein kinase , putative	0.0068	0.0402	1
Echinococcus multilocularis	roundabout 2	0.0019	0.0011	0.0114
Echinococcus multilocularis	roundabout 2	0.003	0.01	0.107
Brugia malayi	Kringle domain containing protein	0.0065	0.0371	0.1201
Schistosoma mansoni	hypothetical protein	0.0071	0.0421	0.3013
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.0402	1
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.0402	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.1368
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0059	0.0323	0.3473
Brugia malayi	hypothetical protein	0.0071	0.0421	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0486
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0421	0.3013
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0011	0.0044
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0323	0.5322
Brugia malayi	Trypsin family protein	0.0071	0.0421	0.1368
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0399	0.1295
Onchocerca volvulus		0.0071	0.0421	0.0962
Onchocerca volvulus		0.0375	0.2827	0.9711
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0071	0.0421	0.4524
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.002	0.0018	0.0024
Trypanosoma brucei	aurora B kinase	0.0068	0.0402	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0421	0.3013
Onchocerca volvulus		0.0071	0.0421	0.0962
Echinococcus multilocularis	aurora kinase A	0.0068	0.0402	0.4321
Brugia malayi	Trypsin family protein	0.0071	0.0421	0.1368
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0421	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Onchocerca volvulus		0.0071	0.0421	0.0962
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0047	0.0233	0.2509
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0402	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0421	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0233	0.0743
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0323	0.5322
Toxoplasma gondii	aspartyl protease ASP1	0.0047	0.0233	0.0078
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0019	0.0014	0.0152
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0402	0.1305
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0398	0.3009	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0156	0.0486
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.0402	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0065	0.0182
Brugia malayi	serine/threonine kinase 12	0.0068	0.0402	0.1305
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0323	0.2306
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.1368
Brugia malayi	PAN domain containing protein	0.0037	0.0156	0.0486
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Echinococcus multilocularis	roundabout 2	0.0019	0.0011	0.0114
Echinococcus multilocularis	enteropeptidase	0.0071	0.0421	0.4524
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0323	0.5322
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.0371	0.603
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0402	0.1305
Schistosoma mansoni	hypothetical protein	0.0065	0.0371	0.265
Onchocerca volvulus		0.0071	0.0421	0.0962
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0156	0.0486
Echinococcus granulosus	Mastin	0.0071	0.0421	0.4524
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0323	0.5322
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0421	0.3013
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.0402	1
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0047	0.0233	0.2509
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.0402	1
Echinococcus granulosus	tissue type plasminogen activator	0.0065	0.0371	0.3984
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.1368

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.5 uM	Inhibition of human recombinant VEGFR2	ChEMBL.	18529047
IC50 (binding)	= 1.7 uM	Inhibition of human recombinant TIE2	ChEMBL.	18529047
IC50 (binding)	= 2.5 uM	Inhibition of human recombinant VEGFR3	ChEMBL.	18529047
IC50 (binding)	= 6.5 uM	Inhibition of human recombinant Aurora A	ChEMBL.	18529047
IC50 (binding)	= 9 uM	Inhibition of human recombinant SAK	ChEMBL.	18529047
IC50 (binding)	= 20 uM	Inhibition of human recombinant Aurora B	ChEMBL.	18529047
IC50 (binding)	= 20 uM	Inhibition of human recombinant CDK2/cyclin A	ChEMBL.	18529047
IC50 (binding)	= 37 uM	Inhibition of human recombinant ERBB2	ChEMBL.	18529047
IC50 (binding)	= 40 uM	Inhibition of human recombinant COT	ChEMBL.	18529047
IC50 (binding)	= 43 uM	Inhibition of human recombinant FAK	ChEMBL.	18529047
IC50 (binding)	= 44 uM	Inhibition of human recombinant CDK4/cyclin D1	ChEMBL.	18529047
IC50 (binding)	= 44 uM	Inhibition of human recombinant INS-R	ChEMBL.	18529047
IC50 (binding)	= 45 uM	Inhibition of human recombinant MET	ChEMBL.	18529047
IC50 (binding)	= 49 uM	Inhibition of human recombinant SRC	ChEMBL.	18529047

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL488811

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 988911