Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0176 | 0.2506 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0602 | 0.0602 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0047 | 0.0272 | 0.1677 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Brugia malayi | nuclear receptor NHR-88 | 0.0066 | 0.0602 | 0.0602 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0035 | 0.0064 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0066 | 0.0602 | 0.0602 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0093 | 0.1068 | 0.5652 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0677 | 0.0677 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0066 | 0.0602 | 0.3707 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0649 | 0.0649 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0066 | 0.0602 | 0.0602 |
Schistosoma mansoni | dihydrofolate reductase | 0.0051 | 0.0344 | 0.2117 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0258 | 0.0258 |
Echinococcus granulosus | dihydrofolate reductase | 0.0051 | 0.0344 | 0.2117 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0066 | 0.0602 | 0.3707 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0602 | 0.0602 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0066 | 0.0602 | 0.3707 |
Schistosoma mansoni | thyroid hormone receptor | 0.0066 | 0.0602 | 0.3707 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | thymidylate synthase | 0.0125 | 0.1624 | 0.1624 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0066 | 0.0602 | 0.0602 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0066 | 0.0602 | 0.0602 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0066 | 0.0602 | 0.3707 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1068 | 0.1068 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0066 | 0.0602 | 0.3707 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0035 | 0.0064 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0649 | 0.0649 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0047 | 0.0272 | 0.1677 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0066 | 0.0602 | 0.3707 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0677 | 0.0677 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0066 | 0.0602 | 0.0602 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0093 | 0.1068 | 0.3885 |
Echinococcus granulosus | thymidylate synthase | 0.0125 | 0.1624 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.026 | 0.3961 | 0.3961 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0649 | 0.0649 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0066 | 0.0602 | 0.3707 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0066 | 0.0602 | 0.3707 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0066 | 0.0602 | 0.0602 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | hypothetical protein | 0.0059 | 0.0491 | 0.0491 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0035 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0677 | 0.0677 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.0272 | 0.1677 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0066 | 0.0602 | 0.0602 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0066 | 0.0602 | 0.3707 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0066 | 0.0602 | 0.3707 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0066 | 0.0602 | 0.3707 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Schistosoma mansoni | nuclear hormone receptor | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0093 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Brugia malayi | dihydrofolate reductase family protein | 0.0051 | 0.0344 | 0.0344 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0066 | 0.0602 | 0.0602 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0176 | 0.2506 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0066 | 0.0602 | 0.3707 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1068 | 0.1068 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0093 | 0.1068 | 0.6573 |
Brugia malayi | follicle stimulating hormone receptor | 0.026 | 0.3961 | 0.3961 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1068 | 0.1068 |
Mycobacterium ulcerans | thymidylate synthase | 0.0125 | 0.1624 | 0.6873 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0159 | 0.2207 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0051 | 0.0344 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0602 | 0.0602 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0047 | 0.0272 | 0.1677 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0066 | 0.0602 | 0.3707 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.0272 | 0.1677 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0066 | 0.0602 | 0.0602 |
Brugia malayi | thymidylate synthase | 0.0125 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0069 | 0.0649 | 0.0649 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0066 | 0.0602 | 0.0602 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0.0491 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0051 | 0.0344 | 0.2117 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0093 | 0.1068 | 0.6573 |
Brugia malayi | nuclear receptor RXR | 0.0035 | 0.0064 | 0.0064 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Schistosoma mansoni | coup transcription factor | 0.0066 | 0.0602 | 0.3707 |
Echinococcus multilocularis | thymidylate synthase | 0.0125 | 0.1624 | 1 |
Brugia malayi | steroid hormone receptor | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0066 | 0.0602 | 0.0602 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0066 | 0.0602 | 0.3707 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0176 | 0.2506 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0066 | 0.0602 | 0.0602 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0066 | 0.0602 | 0.3707 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0125 | 0.1624 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0051 | 0.0344 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0035 | 0.0064 | 0.0397 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0609 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0066 | 0.0602 | 0.0602 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0176 | 0.2506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0649 | 0.0649 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0093 | 0.1068 | 0.3885 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0035 | 0.0064 | 0.0397 |
Onchocerca volvulus | 0.0066 | 0.0602 | 0.3707 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0066 | 0.0602 | 0.0602 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0125 | 0.1624 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0035 | 0.0064 | 0.0064 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0677 | 0.0677 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0176 | 0.2506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0677 | 0.0677 |
Schistosoma mansoni | thyroid hormone receptor | 0.0066 | 0.0602 | 0.3707 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0059 | 0.0491 | 0.0789 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0066 | 0.0602 | 0.0602 |
Onchocerca volvulus | 0.0046 | 0.0258 | 0.1586 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0602 | 0.0602 |
Onchocerca volvulus | 0.0125 | 0.1624 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0602 | 0.0602 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0066 | 0.0602 | 0.3707 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0066 | 0.0602 | 0.3707 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0093 | 0.1068 | 0.6573 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0176 | 0.2506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0677 | 0.0677 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0066 | 0.0602 | 0.0602 |
Brugia malayi | Peptidase family M13 containing protein | 0.0093 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0051 | 0.0344 | 0.0344 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0125 | 0.1624 | 0.6873 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0066 | 0.0602 | 0.3707 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0066 | 0.0602 | 0.0602 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0159 | 0.2207 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0069 | 0.0649 | 0.0649 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0066 | 0.0602 | 0.3707 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0035 | 0.0064 | 0.0397 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0066 | 0.0602 | 0.3707 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0066 | 0.0602 | 0.3707 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0066 | 0.0602 | 0.0602 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 9 % | Inhibition of GST-SIRT2 at 200 uM after 1 hr by Fluor de Lys fluorescence assay | ChEMBL. | 20630764 |
Inhibition (binding) | = 20 % | Inhibition of GST-SIRT1 at 200 uM after 1 hr by Fluor de Lys fluorescence assay | ChEMBL. | 20630764 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.