Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0066 | 0.0294 | 0.0294 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0073 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0073 | 0.0343 | 0.0343 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0066 | 0.0294 | 1 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.1511 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0073 | 0.0343 | 0.0343 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0025 | 0.0021 | 0.0021 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0075 | 0.0357 | 0.0357 |
Schistosoma mansoni | kinase | 0.0066 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0073 | 0.0343 | 0.0343 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0343 | 0.0343 |
Plasmodium falciparum | MO15-related protein kinase | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.1511 | 1 | 1 | |
Brugia malayi | cyclin-dependent kinase 9 | 0.0066 | 0.0294 | 0.0294 |
Echinococcus multilocularis | serotonin transporter | 0.0073 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.1882 | 0.1882 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0073 | 0.0343 | 0.0343 |
Trypanosoma brucei | protein kinase, putative | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.1511 | 1 | 1 | |
Trypanosoma brucei | Mitogen-activated protein kinase 10, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0073 | 0.0343 | 0.0343 |
Giardia lamblia | Kinase, CDC7 | 0.1511 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0066 | 0.0294 | 0.0294 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0022 | 0 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0.0343 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0073 | 0.0343 | 0.0343 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1511 | 1 | 1 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0066 | 0.0294 | 0.0294 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1511 | 1 | 1 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.1511 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1511 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.0066 | 0.0294 | 0.0294 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.1511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0343 | 0.0343 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0075 | 0.0357 | 0.0357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.