Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hexokinase family protein | 0.0096 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0031 | 0.2545 | 0.2545 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.4205 | 0.4205 |
Toxoplasma gondii | hexokinase | 0.0096 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0432 | 0.0432 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0432 | 0.0432 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.3463 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.3772 | 0.3772 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0096 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.5927 | 0.5927 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.3463 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0432 | 0.0432 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.3151 | 0.3151 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0432 | 0.0432 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.3772 | 0.3772 |
Brugia malayi | Hexokinase family protein | 0.003 | 0.2452 | 0.2452 |
Loa Loa (eye worm) | hexokinase | 0.003 | 0.2452 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2545 | 0.2545 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2545 | 0.2545 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0432 | 0.0432 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.3772 | 0.3772 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.4205 | 0.4205 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0432 | 0.0432 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.3772 | 0.3772 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.6525 | 0.6525 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.5927 | 0.5927 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.61 | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli assessed as maximal activating response by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay relative to 2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(4-methylthiazol-2-yl)benzamide in presence of 10 mM glucose | ChEMBL. | 19282189 |
Activity (binding) | = 0.76 | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli assessed as maximal activating response by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay relative to 2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(4-methylthiazol-2-yl)benzamide in presence of 2.5 mM glucose | ChEMBL. | 19282189 |
EC50 (binding) | = 1.5 uM | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose | ChEMBL. | 19282189 |
EC50 (binding) | = 1.5 uM | Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose | ChEMBL. | 19188063 |
EC50 (binding) | = 7.3 uM | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose | ChEMBL. | 19282189 |
EC50 (binding) | = 7.3 uM | Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose | ChEMBL. | 19188063 |
FC (binding) | = 1.6 | Activation of human glucokinase assessed as maximal response by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose relative to control | ChEMBL. | 19188063 |
FC (binding) | = 8 | Activation of human glucokinase assessed as maximal response by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose relative to control | ChEMBL. | 19188063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.