TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.904 | Formula: C18H23ClN2O4S
H donors: 3 H acceptors: 3 LogP: 2.4 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O[C@H](COc1ccc(cc1)NS(=O)(=O)C)CNCCc1ccc(cc1)Cl
InChi: 1S/C18H23ClN2O4S/c1-26(23,24)21-16-6-8-18(9-7-16)25-13-17(22)12-20-11-10-14-2-4-15(19)5-3-14/h2-9,17,20-22H,10-13H2,1H3/t17-/m0/s1
InChiKey: VMIBLDKZGHZFMI-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate NMDA receptor; Grin1/Grin2b		References
Rattus norvegicus	Glutamate (NMDA) receptor subunit zeta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	glutamate receptor NMDA	Glutamate NMDA receptor; Grin1/Grin2b	938 aa	933 aa	39.1 %
Drosophila melanogaster	Glutamate receptor IA	Glutamate (NMDA) receptor subunit zeta 1	938 aa	979 aa	23.7 %
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	Glutamate (NMDA) receptor subunit zeta 1	938 aa	822 aa	23.2 %
Drosophila melanogaster	NMDA receptor 2	Glutamate (NMDA) receptor subunit zeta 1	938 aa	878 aa	27.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Echinococcus granulosus	glutamate receptor NMDA	0.0095	0.1668	0.2344
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Brugia malayi	Frizzled/Smoothened family membrane region containing protein	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0043	0.0072	0.0101
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0046	0.016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Loa Loa (eye worm)	neuropeptide F receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Brugia malayi	Melatonin receptor type 1A	0.0043	0.0072	0.0101
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0046	0.016	0.5
Schistosoma mansoni	opsin-like receptor	0.0043	0.0072	0.0101
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0043	0.0072	0.0101
Echinococcus granulosus	neuropeptide s receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	frizzled-like receptor	0.0094	0.1637	0.2301
Schistosoma mansoni	histamine h1 receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1637	0.2301
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	G-protein coupled receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	sex peptide receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	nmda type glutamate receptor	0.0159	0.3624	0.5093
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Schistosoma mansoni	neuropeptide f receptor 76f	0.0043	0.0072	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Echinococcus granulosus	smoothened	0.0094	0.1637	0.2301
Echinococcus multilocularis	orexin receptor type 2	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	secreted frizzled protein 5	0.0094	0.1637	0.2301
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0043	0.0072	0.0101
Brugia malayi	G-protein coupled receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	amine GPCR	0.0043	0.0072	0.0101
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0026	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	neuropeptide receptor	0.0043	0.0072	0.0101
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0026	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0043	0.0072	0.0101
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0043	0.0072	0.0101
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0043	0.0072	0.0101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Brugia malayi	Fz domain containing protein	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Echinococcus granulosus	frizzled 5	0.0094	0.1637	0.2301
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Echinococcus granulosus	neuropeptide Y receptor	0.0043	0.0072	0.0101
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0043	0.0072	0.0101
Schistosoma mansoni	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	frizzled	0.0094	0.1637	0.2301
Echinococcus granulosus	secreted frizzled protein	0.0094	0.1637	0.2301
Echinococcus multilocularis	g protein coupled receptor	0.0043	0.0072	0.0101
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0241	0.0339
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0043	0.0072	0.0101
Echinococcus multilocularis	frizzled	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	neuropeptide Y receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	frizzled/Smoothened family membrane region containing protein	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	amine GPCR	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	tm gpcr rhodopsin	0.0043	0.0072	0.0101
Echinococcus granulosus	dro:myosuppressin receptor	0.0043	0.0072	0.0101
Brugia malayi	GnHR receptor homolog	0.0043	0.0072	0.0101
Echinococcus multilocularis	dro:myosuppressin receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	sex peptide receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	orexin receptor type 2	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptides capa receptor	0.0043	0.0072	0.0101
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptide s receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Brugia malayi	Unc-6 protein precursor	0.0273	0.7115	1
Echinococcus granulosus	g protein coupled receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	tm gpcr rhodopsin	0.0043	0.0072	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Schistosoma mansoni	neuropeptide receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	neuropeptide receptor A26	0.0043	0.0072	0.0101
Schistosoma mansoni	biogenic amine receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	fmrfamide receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	G-protein coupled receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	g protein coupled receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Schistosoma mansoni	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	glutamate receptor NMDA	0.0122	0.2498	0.3511
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0046	0.016	0.5
Echinococcus granulosus	g protein coupled receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0043	0.0072	0.0101
Brugia malayi	neuropeptide F receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	frizzled	0.0094	0.1637	0.2301
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	serotonin receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	nmda type glutamate receptor	0.0159	0.3624	0.5093
Echinococcus multilocularis	fmrfamide receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptide Y receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	nmda type glutamate receptor	0.0104	0.1949	0.2739
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Brugia malayi	sulfakinin receptor protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	amine GPCR	0.0043	0.0072	0.0101
Echinococcus granulosus	7TM GPCR rhodopsin	0.0043	0.0072	0.0101
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	netrin 1	0.0273	0.7115	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0043	0.0072	0.0101
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0043	0.0072	0.0101
Schistosoma mansoni	opsin-like receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	allatostatin A receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0064	0.0709	0.0996
Brugia malayi	follicle stimulating hormone receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	neuropeptide F-like receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	frizzled 4	0.0094	0.1637	0.2301
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0043	0.0072	0.0101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Echinococcus granulosus	frizzled	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	somatostatin receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptide receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	wnt inhibitor frzb2	0.0094	0.1637	0.2301
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0043	0.0072	0.0101
Brugia malayi	G protein-coupled receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	hypothetical protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0043	0.0072	0.0101
Brugia malayi	AKH receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptide Y receptor	0.0043	0.0072	0.0101
Brugia malayi	Fz domain containing protein	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1637	0.2301
Brugia malayi	neuropeptide F receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	G protein coupled receptor 139	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0043	0.0072	0.0101
Echinococcus granulosus	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0043	0.0072	0.0101
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0043	0.0072	0.0101
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	growth hormone secretagogue receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptide receptor A26	0.0043	0.0072	0.0101
Echinococcus multilocularis	g-protein coupled receptor	0.0043	0.0072	0.0101
Brugia malayi	Serotonin receptor	0.0043	0.0072	0.0101
Chlamydia trachomatis	glutamine binding protein	0.0046	0.016	0.5
Echinococcus multilocularis	secreted frizzled protein 5	0.0094	0.1637	0.2301
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0043	0.0072	0.0101
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0241	0.0339
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0043	0.0072	0.0101
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0046	0.016	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	netrin	0.0273	0.7115	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	nmda type glutamate receptor	0.0104	0.1949	0.2739
Echinococcus multilocularis	fmrfamide receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	myosin xvIII	0.0043	0.0072	0.0101
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	sfrp2	0.0094	0.1637	0.2301
Brugia malayi	G protein-coupled receptor F59B2.13	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptide receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0043	0.0072	0.0101
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	frizzled	0.0094	0.1637	0.2301
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	frizzled-like receptor	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	serotonin receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	frizzled 5	0.0094	0.1637	0.2301
Brugia malayi	Dopamine receptor protein 1	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0043	0.0072	0.0101
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0043	0.0072	0.0101
Echinococcus multilocularis	somatostatin receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	amine GPCR	0.0043	0.0072	0.0101
Schistosoma mansoni	netrin	0.0273	0.7115	1
Echinococcus granulosus	frizzled	0.0094	0.1637	0.2301
Echinococcus multilocularis	serotonin receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	secreted frizzled protein	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	neuropeptide FF receptor 2	0.0043	0.0072	0.0101
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	frizzled/Smoothened family membrane region containing protein	0.0094	0.1637	0.2301
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0043	0.0072	0.0101
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0043	0.0072	0.0101
Brugia malayi	larval opioid receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0116	0.0163
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Brugia malayi	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0116	0.0163
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0043	0.0072	0.0101
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0116	0.0163
Echinococcus multilocularis	g protein coupled receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	neuropeptide F receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0043	0.0072	0.0101
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0043	0.0072	0.0101
Brugia malayi	Dopamine receptor protein 2	0.0043	0.0072	0.0101
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	neuropeptide receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	biogenic amine receptor	0.0043	0.0072	0.0101
Brugia malayi	putative neuropeptide receptor	0.0043	0.0072	0.0101
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0046	0.016	0.5
Echinococcus granulosus	frizzled 4	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0273	0.7115	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Schistosoma mansoni	opsin-like receptor	0.0043	0.0072	0.0101
Brugia malayi	Dopamine receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0116	0.0163
Echinococcus multilocularis	netrin 1	0.0273	0.7115	1
Loa Loa (eye worm)	TYRA-2 protein	0.0043	0.0072	0.0101
Echinococcus granulosus	7tm_1 domain containing protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Loa Loa (eye worm)	melatonin receptor type 1A	0.0043	0.0072	0.0101
Echinococcus multilocularis	secreted frizzled protein	0.0094	0.1637	0.2301
Echinococcus granulosus	g protein coupled receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	g-protein coupled receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0043	0.0072	0.0101
Brugia malayi	Serotonin receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	biogenic amine 5HT receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	G protein coupled receptor 139	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus multilocularis	neuropeptides capa receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0043	0.0072	0.0101
Echinococcus granulosus	neuropeptides capa receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	neuropeptide receptor	0.0043	0.0072	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	allatostatin A receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	secreted frizzled-related protein	0.0094	0.1637	0.2301
Brugia malayi	RE15519p	0.0043	0.0072	0.0101
Schistosoma mansoni	amine GPCR	0.0043	0.0072	0.0101
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	tm gpcr rhodopsin	0.0043	0.0072	0.0101
Echinococcus multilocularis	glutamate receptor NMDA	0.0095	0.1668	0.2344
Echinococcus granulosus	neuropeptide receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	hypothetical protein	0.0043	0.0072	0.0101
Brugia malayi	ORL1-like opioid receptor	0.0043	0.0072	0.0101
Echinococcus granulosus	neuropeptides capa receptor	0.0043	0.0072	0.0101
Echinococcus multilocularis	frizzled 10	0.0094	0.1637	0.2301
Echinococcus multilocularis	smoothened	0.0094	0.1637	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0072	0.0101
Echinococcus granulosus	biogenic amine 5HT receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	adenoreceptor	0.0043	0.0072	0.0101
Brugia malayi	G-protein coupled receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	biogenic amine receptor	0.0043	0.0072	0.0101
Schistosoma mansoni	neuropeptide receptor	0.0043	0.0072	0.0101
Brugia malayi	Frizzled/Smoothened family membrane region containing protein	0.0094	0.1637	0.2301
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0043	0.0072	0.0101

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.101 uM	Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method	ChEMBL.	18800760
IC50 (binding)	= 1.39 uM	Displacement of [3H]astemizole from human ERG expressed in HEK293 cells	ChEMBL.	18800760

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL492846

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 991479